<SEC-DOCUMENT>0001140361-23-031597.txt : 20230627
<SEC-HEADER>0001140361-23-031597.hdr.sgml : 20230627
<ACCEPTANCE-DATETIME>20230627080231
ACCESSION NUMBER:		0001140361-23-031597
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20230627
DATE AS OF CHANGE:		20230627
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Alkermes plc.
		CENTRAL INDEX KEY:			0001520262
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				981007018
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86627
		FILM NUMBER:		231044003

	BUSINESS ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00-353-1-772-8000

	MAIL ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
		DATE OF NAME CHANGE:	20110804

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Antler Science Two Ltd
		DATE OF NAME CHANGE:	20110509

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>brhc20054920_sc13da.htm
<DESCRIPTION>SC 13D/A
<TEXT>
<html>
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    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 14pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 12pt;">Washington, D.C. 20549</div>
    <br>
    <div style="text-align: center; color: rgb(0, 0, 0); font-size: 18pt; font-weight: bold;">SCHEDULE 13D</div>
    <div><br>
    </div>
    <div style="text-align: center; color: rgb(0, 0, 0);">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">(Amendment No. 14)*</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7958fd0b12b842f18cc069dc00720489">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0); font-size: 24pt;">
            <div style="text-align: center; color: rgb(0, 0, 0);">Alkermes Public Limited Company</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">(Name of Issuer)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z7d68d1e146dc4431b893c3c1458e7bac">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">Ordinary shares, $0.01 par value</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">(Title of Class of Securities)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zda7187aeb5304616b78f74ffea3e503c">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">G01767105</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">(CUSIP Number)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="z84023d50c2c54ca2a04af88e421d27a3">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">Mark DiPaolo</div>
            <div style="text-align: center; color: #000000;">Senior Partner, General Counsel</div>
            <div style="text-align: center; color: #000000;">Sarissa Capital Management LP</div>
            <div style="text-align: center; color: #000000;">660 Steamboat Road</div>
            <div style="text-align: center; color: #000000;">Greenwich, CT 06830</div>
            <div style="text-align: center; color: #000000;">203-302-2330</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">(Name, Address and Telephone Number of Person</div>
            <div style="text-align: center; color: #000000;">Authorized to Receive Notices and Communications)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="zfbfb7abda8034e7aadb5190f1f12fb6a">

        <tr>
          <td style="width: 100%; vertical-align: top; border-bottom: #000000 2px solid;">
            <div style="text-align: center; color: #000000;">June 26, 2023</div>
          </td>
        </tr>
        <tr>
          <td style="width: 100%; vertical-align: top;">
            <div style="text-align: center; color: #000000;">(Date of Event which Requires Filing of this Statement)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">If the filing person has previously filed a statement on Schedule 13G to report the acquisition which is the subject of this Schedule 13D, and is filing this schedule because of Rule 13d-1(e), 13d-1(f)
      or 13d-1(g), check the following box. &#9744;</div>
    <div>&#160;</div>
    <div style="text-align: justify; color: #000000;"><font style="font-weight: bold;">Note:</font>&#160; Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See Rule 13d-7 for other parties
      to whom copies are to be sent.</div>
    <div>&#160;</div>
    <div style="color: #000000;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would
      alter disclosures provided in a prior cover page.</div>
    <div><br>
    </div>
    <div style="text-align: justify; color: #000000;">The information required on the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 or otherwise subject to the
      liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
    <div><br>
    </div>
    <div>
      <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; text-align: center; margin-left: auto; margin-right: auto;"></div>
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        <div>
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              <tr>
                <td style="width: 50.00%;">
                  <div style="text-align: left;">CUSIP No. G01767105</div>
                </td>
                <td style="width: 50.00%;">
                  <div style="text-align: right;">Page <font class="BRPFPageNumber">2</font> of 4 Pages</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="1" style="width: 50.00%;">
                  <div style="text-align: center;">SCHEDULE 13D</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div style="color: #000000;">This Amendment No. 14 to Schedule 13D (&#8220;Amendment No. 14&#8221;) relates to ordinary shares, par value $0.01 per share (&#8220;Common Stock&#8221; and, such shares, the &#8220;Shares&#8221;), issued by Alkermes Public Limited Company, a company
      incorporated under the laws of Ireland (the &#8220;Issuer&#8221;), and amends the initial statement on Schedule 13D filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on May 10, 2021 (the &#8220;Initial Schedule 13D&#8221;), as amended by Amendment No. 1 to
      Schedule 13D filed on May 27, 2021, Amendment No. 2 to Schedule 13D filed on September 10, 2021, Amendment No. 3 to Schedule 13D filed on November 19, 2021, Amendment No. 4 to Schedule 13D filed on January 10, 2022, Amendment No. 5 to Schedule 13D
      filed on July 6, 2022, Amendment No. 6 to Schedule 13D filed on October 7, 2022, Amendment No. 7 to Schedule 13D filed on February 6, 2023, Amendment No. 8 to Schedule 13D filed on June 5, 2023, Amendment No. 9 to Schedule 13D filed on June 12, 2023,
      Amendment No. 10 to Schedule 13D filed on June 14, 2023, Amendment No. 11 to Schedule 13D filed on June 16, 2023, Amendment No. 12 to Schedule 13D filed on June 21, 2023 and Amendment No. 13 to Schedule 13D filed on June 23, 2023 (the Initial
      Schedule 13D, as so amended, the &#8220;Schedule 13D&#8221;), on behalf of the Reporting Persons, to furnish the additional information set forth herein. All capitalized terms contained herein but not otherwise defined shall have the meanings ascribed to such
      terms in the Schedule 13D.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z67b0d221994a481cbef1f8fe0fabbe44">

        <tr>
          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 4.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-weight: bold;">Purpose of Transaction.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div>Item 4 of the Schedule 13D is hereby amended to include the following:</div>
    <div><br>
    </div>
    <div style="text-align: justify;">On June 26, 2023, Sarissa Capital issued the press release attached as Exhibit 10 hereto.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za3206566fb3444339822b20b4d13cca6">

        <tr>
          <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0); font-weight: bold;">Item 7.</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div style="color: #000000; font-weight: bold;">Material to Be Filed as Exhibits.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div><font style="color: #000000;">Item 7 of the Schedule 13D </font>is hereby amended to include the following:</div>
    <div><br>
    </div>
    <div style="color: #000000;">Exhibit 10 - Press Release, June 26, 2023</div>
    <div style="color: #000000;"> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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              <tr>
                <td style="width: 50.00%;">
                  <div style="text-align: left;">CUSIP No. G01767105</div>
                </td>
                <td style="width: 50.00%;">
                  <div style="text-align: right;">Page <font class="BRPFPageNumber">3</font> of 4 Pages</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="1" style="width: 50.00%;">
                  <div style="text-align: center;">SCHEDULE 13D</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div style="text-align: center; color: #000000; font-weight: bold;">SIGNATURE</div>
    <div>&#160;</div>
    <div style="text-align: justify; text-indent: 36pt; color: #000000;">After reasonable inquiry and to the best of my knowledge and belief, the undersigned certifies that the information set forth in this statement is true, complete and correct.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" id="za9b62b91e6d84b8d9e3c87b327f20757">

        <tr>
          <td colspan="3" style="vertical-align: top;">
            <div style="color: #000000;">Dated:&#160; June 27, 2023</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;"><br>
          </td>
          <td style="width: 50%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td colspan="3" style="vertical-align: top;">
            <div style="color: #000000;">SARISSA CAPITAL MANAGEMENT LP</div>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;"><br>
          </td>
          <td style="width: 50%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top; padding-bottom: 2px;">
            <div style="color: #000000;">By:</div>
          </td>
          <td style="width: 47%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">/s/ Mark DiPaolo</td>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;"><br>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 47%; vertical-align: top;">
            <div style="color: #000000;">Name: Mark DiPaolo</div>
          </td>
          <td style="width: 50%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td style="width: 3%; vertical-align: top;">&#160;</td>
          <td style="width: 47%; vertical-align: top;">
            <div style="color: #000000;">Title: Senior Partner, General Counsel</div>
          </td>
          <td style="width: 50%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top;"><br>
          </td>
          <td style="width: 50%; vertical-align: top;"><br>
          </td>
        </tr>
        <tr>
          <td colspan="2" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="color: #000000;">/s/Alexander J. Denner</div>
          </td>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;"><br>
          </td>
        </tr>
        <tr>
          <td colspan="3" style="vertical-align: top;">
            <div style="color: #000000;">Alexander J. Denner</div>
          </td>
        </tr>

    </table>
    <div> <br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
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                <td style="width: 50.00%;">
                  <div style="text-align: left;">CUSIP No. G01767105</div>
                </td>
                <td style="width: 50.00%;">
                  <div style="text-align: right;">Page <font class="BRPFPageNumber">4</font> of 4 Pages</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="1" style="width: 50.00%;">
                  <div style="text-align: center;">SCHEDULE 13D</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
    </div>
    <div>
      <div style="text-align: center; color: #000000; font-weight: bold;">INDEX TO EXHIBITS</div>
    </div>
    <div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/ix?doc=/Archives/edgar/data/0001520262/000119312521142486/d171777d8k.htm">Exhibit 1</a> - Form 8-K of the Issuer filed with the U.S. Securities and Exchange Commission on April 30, 2021
        (incorporated by reference in this Schedule 13D)*</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914021000485/s42631058b.htm">Exhibit 2</a> - Joint Filing Agreement of the Reporting Persons, dated as of May 10, 2021*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000089914022000583/s54639944b.htm">Exhibit 3</a> - Press Release, July 6, 2022*</div>
      <div><font style="color: #000000;"> </font><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123028238/ny20009418x2_ex4.htm">Exhibit 4</a> - Press Release, June 5, 2023*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029264/ny20009418x6_ex5.htm">Exhibit 5</a> - Press Release, June 9, 2023*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1520262/000114036123029760/ny20009418x8_ex6.htm">Exhibit 6</a> - Press Release, June 13, 2023*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1577524/000114036123030189/ny20009418x10_ex7.htm">Exhibit 7</a> - Press Release, June 15, 2023*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1577524/000114036123030633/brhc20054642_ex8.htm">Exhibit 8</a> - Press Release, June 20, 2023*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="https://www.sec.gov/Archives/edgar/data/1577524/000114036123031057/brhc20054765_ex9.htm">Exhibit 9</a> - Press Release, June 22, 2023*</div>
      <div><br>
      </div>
      <div style="color: #000000;"><a href="brhc20054920_ex99-10.htm">Exhibit 10</a> - Press Release, June 26, 2023</div>
      <div><br>
      </div>
      <div style="color: #000000;">* Previously filed.</div>
      <div><br>
      </div>
      <div>
        <div style="text-align: right; color: #000000; font-weight: bold;"><a name="EXHIBIT10"><!--Anchor--></a></div>
      </div>
    </div>
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<DOCUMENT>
<TYPE>EX-99.10
<SEQUENCE>2
<FILENAME>brhc20054920_ex99-10.htm
<DESCRIPTION>EXHIBIT 10
<TEXT>
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    <!-- Licensed to: Summit Financial
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      <div>
        <div style="text-align: right; color: #000000; font-weight: bold;">EXHIBIT 10</div>
        <div><br>
          <div style="text-align: center; font-weight: bold;">SARISSA ISSUES PRESENTATION HIGHLIGHTING SARISSA NOMINEES ARE QUALIFIED TO CREATE VALUE FOR ALKERMES SHAREHOLDERS</div>
          <div><br>
          </div>
          <div style="text-align: center; font-weight: bold;">Independent proxy advisory firm ISS recognizes the qualifications of Sarissa nominees and advises shareholders to support Sarah Schlesinger</div>
          <div><br>
          </div>
          <div style="text-align: center; font-weight: bold;">In light of upcoming oncology spin, ISS recommends that shareholders withhold support from cancer specialist Richard Gaynor</div>
          <div><br>
          </div>
          <div style="text-align: justify;">Greenwich, CT, June 26, 2023 &#8211; Sarissa Capital Management LP (&#8220;Sarissa&#8221;) today issued a presentation detailing the need for shareholder representation on the board of Alkermes plc (NASDAQ: ALKS) accessible at the
            link below:</div>
          <div><br>
          </div>
          <div style="font-size: 12pt;"><font style="font-size: 10pt; font-weight: bold;">Presentation</font><font style="font-size: 10pt;">: <u>https://upgradealkermes.com/pr062623</u></font></div>
          <div><br>
          </div>
          <div style="font-size: 12pt;"><font style="font-size: 10pt; color: rgb(0, 0, 0);">For additional information please visit our we<font style="color: rgb(0, 0, 0);">bsite at </font>upgradealkermes.com.</font></div>
          <div style="color: rgb(0, 0, 0);">#UpgradeAlkermes</div>
          <div style="color: rgb(0, 0, 0);"><br>
          </div>
          <div style="color: rgb(0, 0, 0);">If you have any questions regarding your BLUE universal proxy card or need assistance in executing your proxy card, please contact:</div>
          <div><br>
          </div>
          <div style="font-weight: bold;">D.F.&#160; King &amp; Co., Inc.</div>
          <div>Shareholders call Toll-Free: (866) 207-3648</div>
          <div>All Others Call: (212) 493-6952</div>
          <div>Email: <u>ALKS@dfking.com</u></div>
          <div><br>
          </div>
          <div>Your vote at Alkermes' Annual General Meeting of Shareholders on June 29, 2023 is very important.&#160; <font style="font-weight: bold;">We urge all shareholders to vote "<u>FOR</u>" the election of the Sarissa Nominees, &#8220;<u>AGAINST</u>&#8221; the
              compensation of the Company&#8217;s named executive officers, and "<u>FOR</u>" all other proposals in our proxy statement.</font></div>
          <br>
          <div>You can vote in one of three easy ways: by internet at <u>www.cesvote.com</u>, by telephone at 1-888-693-8683 or by mail using the <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card and postage-paid envelope sent to
            you.</div>
          <br>
          <div>If you vote by internet or telephone, you will be required to provide the unique control number printed on your <font style="font-weight: bold;"><u>BLUE</u></font> universal proxy card.</div>
          <div><br>
          </div>
          <div>
            <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman'; font-size: 10pt; color: #000000; width: 100%;">

                <tr>
                  <td style="width: 10%;">Contact:</td>
                  <td style="width: 90%;">
                    <div>Dayna Packes</div>
                  </td>
                </tr>
                <tr>
                  <td style="width: 10%;"><br>
                  </td>
                  <td style="width: 90%;">Sarissa Capital Management LP</td>
                </tr>
                <tr>
                  <td style="width: 10%;"><br>
                  </td>
                  <td style="width: 90%;"><u>info@sarissacap.com</u></td>
                </tr>

            </table>
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        <div style="font-weight: bold;">Additional Information</div>
        <div><br>
        </div>
        <div style="color: rgb(0, 0, 0);">Sarissa Capital Management LP (&#8220;Sarissa Capital&#8221;), together with other participants, filed a definitive proxy statement and an accompanying BLUE universal proxy card with the SEC on June 2, 2023, in connection with
          the solicitation of shareholders of the Company for the 2023 annual general meeting of shareholders (the &#8220;Annual Meeting&#8221;). Shareholders are advised to read the definitive proxy statement and other documents related to the Annual Meeting as they
          contain important information.</div>
        <div><br>
        </div>
        <div style="font-size: 12pt;"><font style="font-size: 10pt; color: rgb(0, 0, 0);">The definitive proxy statement and other relevant documents are available at no charge on the SEC&#8217;s website at </font><u><font style="font-size: 10pt;">www.sec.gov</font></u><font style="font-size: 10pt; color: rgb(0, 0, 0);">. The definitive proxy statement and other relevant documents filed by Sarissa Capital are also available at no charge at </font><u><font style="font-size: 10pt;">www.upgradealkermes.com</font></u><font style="font-size: 10pt; color: rgb(0, 0, 0);"> or by directing a request to Sarissa Capital&#8217;s proxy solicitor, D.F. King &amp; Co., Inc., 48 Wall Street, New York, New York 10005 (Shareholders can call toll-free: (866) 207-3648).</font></div>
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