    <SEC-DOCUMENT>0001140361-23-028388-index.html : 20230605
    <SEC-HEADER>0001140361-23-028388.hdr.sgml : 20230605
    <ACCEPTANCE-DATETIME>20230605165406
    ACCESSION NUMBER:		0001140361-23-028388
    CONFORMED SUBMISSION TYPE:	DFAN14A
    PUBLIC DOCUMENT COUNT:		10
    FILED AS OF DATE:		20230605
    DATE AS OF CHANGE:		20230605

    SUBJECT COMPANY:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Alkermes plc.
    		CENTRAL INDEX KEY:			0001520262
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				981007018
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DFAN14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-35299
    		FILM NUMBER:		23993408

    	BUSINESS ADDRESS:
    		STREET 1:		CONNAUGHT HOUSE
    		STREET 2:		1 BURLINGTON ROAD
    		CITY:			DUBLIN 4
    		STATE:			L2
    		ZIP:			00000
    		BUSINESS PHONE:		00-353-1-772-8000

    	MAIL ADDRESS:
    		STREET 1:		CONNAUGHT HOUSE
    		STREET 2:		1 BURLINGTON ROAD
    		CITY:			DUBLIN 4
    		STATE:			L2
    		ZIP:			00000

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
    		DATE OF NAME CHANGE:	20110804

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Antler Science Two Ltd
    		DATE OF NAME CHANGE:	20110509

    FILED BY:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
    		CENTRAL INDEX KEY:			0001577524
    		IRS NUMBER:				900924432
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DFAN14A

    	BUSINESS ADDRESS:
    		STREET 1:		660 STEAMBOAT ROAD
    		CITY:			GREENWICH
    		STATE:			CT
    		ZIP:			06830
    		BUSINESS PHONE:		203-302-2330

    	MAIL ADDRESS:
    		STREET 1:		660 STEAMBOAT ROAD
    		CITY:			GREENWICH
    		STATE:			CT
    		ZIP:			06830
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DFAN14A
    <SEQUENCE>1
    <FILENAME>ny20009418x1_dfan14a.htm
    <DESCRIPTION>DFAN14A
    <TEXT>
    Document 1 - file: ny20009418x1_dfan14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-1
    <SEQUENCE>2
    <FILENAME>ny20009418x1_ex1.htm
    <DESCRIPTION>EXHIBIT 1
    <TEXT>
    Document 2 - file: ny20009418x1_ex1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>ny20009418x1_ex1image-1.jpg
    <TEXT>
    Document 3 - file: ny20009418x1_ex1image-1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>ny20009418x1_ex1image-4.jpg
    <TEXT>
    Document 4 - file: ny20009418x1_ex1image-4.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>ny20009418x1_ex1image-5.jpg
    <TEXT>
    Document 5 - file: ny20009418x1_ex1image-5.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>ny20009418x1_ex1image-6.jpg
    <TEXT>
    Document 6 - file: ny20009418x1_ex1image-6.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>ny20009418x1_ex1image-7.jpg
    <TEXT>
    Document 7 - file: ny20009418x1_ex1image-7.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>ny20009418x1_ex1image-8.jpg
    <TEXT>
    Document 8 - file: ny20009418x1_ex1image-8.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>ny20009418x1_ex1image-9.jpg
    <TEXT>
    Document 9 - file: ny20009418x1_ex1image-9.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>ny20009418x1_ex1image-10.jpg
    <TEXT>
    Document 10 - file: ny20009418x1_ex1image-10.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>