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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net income (loss) | $ 367,070 | $ 355,757 | $ (158,267)
Adjustments to reconcile net income (loss) to cash flows from operating activities: |  |  |
Depreciation and amortization | 28,533 | 74,927 | 77,862
Share-based compensation expense | 96,637 | 100,905 | 94,254
Deferred income taxes | 40,522 | (99,902) | (32,795)
Change in the fair value of contingent consideration |  |  | 21,750
Other non-cash charges | 4,512 | 6,329 | 5,531
Changes in assets and liabilities: |  |  |
Receivables | (52,052) | (44,510) | 25,250
Contract assets | (4,284) | 8,223 | 4,434
Inventory | 3,091 | (2,712) | (31,021)
Prepaid expenses and other assets | 2,254 | (34,847) | (5,328)
Right-of-use assets | 7,215 | 15,387 | 16,569
Accounts payable and accrued expenses | (57,967) | 23,009 | 15,534
Accrued sales discounts, allowances and reserves | 8,811 | 11,526 | 14,899
Contract liabilities | (3,525) | (5,926) | (7,129)
Operating lease liabilities | (10,123) | (16,147) | (33,225)
Other long-term liabilities | 8,430 | 9,334 | 12,726
Cash flows provided by operating activities | 439,124 | 401,353 | 21,044
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Additions of property, plant and equipment | (33,484) | (48,048) | (38,255)
Proceeds from the sale of equipment | 461 | 354 |
Proceeds from contingent consideration |  |  | 1,273
Return of Fountain Healthcare Partners II, L.P. investment | 43 |  | 485
Proceeds from the sale of the Athlone Facility | 97,933 |  |
Purchases of investments | (486,547) | (254,471) | (309,671)
Sales and maturities of investments | 310,286 | 355,522 | 281,627
Cash flows (used in) provided by investing activities | (111,308) | 53,357 | (64,541)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Cash transferred to Mural Oncology plc at separation |  | (275,000) |
Proceeds from the issuance of ordinary shares under share-based compensation arrangements | 27,572 | 16,760 | 19,630
Employee taxes paid related to net share settlement of equity awards | (29,637) | (28,474) | (18,204)
Payment for the repurchase of ordinary shares | (200,282) |  |
Prepayment of long-term debt | (289,542) |  |
Principal payments of long-term debt | (2,250) | (3,000) | (3,000)
Cash flows used in financing activities | (494,139) | (289,714) | (1,574)
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS | (166,323) | 164,996 | (45,071)
CASH AND CASH EQUIVALENTS—Beginning of period | 457,469 | 292,473 | 337,544
CASH AND CASH EQUIVALENTS—End of period | 291,146 | 457,469 | 292,473
SUPPLEMENTAL CASH FLOW DISCLOSURE: |  |  |
Cash paid for interest | 23,010 | 22,748 | 13,563
Cash paid for taxes | 2,592 | 44,243 | 20,749
Non-cash investing and financing activities: |  |  |
Purchased capital expenditures included in accounts payable and accrued expenses | $ 2,254 | $ 2,645 | $ 2,950

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