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Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended |
--- | --- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Income Taxes [Line Items] |  |  |  |
Tax benefits included in discontinued operations | $ 700 | $ 1,400 | $ 11,100 |
Cumulative unremitted earnings of overseas subsidiaries | 933,500 |  |  |
Valuation allowance | 79,727 | 129,296 | $ 271,517 | $ 249,112
State tax credits | $ 34,000 |  |  |
Minimum |  |  |  |
Income Taxes [Line Items] |  |  |  |
Period after loss carryforwards utilized that tax returns remain open to examination | 3 years |  |  |
Maximum |  |  |  |
Income Taxes [Line Items] |  |  |  |
Period after loss carryforwards utilized that tax returns remain open to examination | 4 years |  |  |
U.S. state |  |  |  |
Income Taxes [Line Items] |  |  |  |
Valuation allowance |  | $ 29,600 |  |
Operating loss carryforwards | $ 43,200 |  |  |
U.S. state | Rodin Therapeutics Incorporation |  |  |  |
Income Taxes [Line Items] |  |  |  |
Operating loss carryforwards | 5,800 |  |  |
U.S. federal |  |  |  |
Income Taxes [Line Items] |  |  |  |
Operating loss carryforwards | 14,100 |  |  |
U.S. federal | Rodin Therapeutics Incorporation |  |  |  |
Income Taxes [Line Items] |  |  |  |
Operating loss carryforwards | 14,100 |  |  |
Federal research and development credits | 500 |  |  |
Ireland |  |  |  |
Income Taxes [Line Items] |  |  |  |
Income taxes payable on repatriation of unremitted earnings | 72,000 |  |  |
Valuation allowance | 50,100 |  |  |
Operating loss carryforwards | $ 393,900 |  |  |
EU |  |  |  |
Income Taxes [Line Items] |  |  |  |
Corporate minimum tax rate |  |  | 15.00% |
Revenues |  |  | $ 750,000 |

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