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CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE INCOME (LOSS) - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
REVENUES:      
Total revenues $ 1,557,632 $ 1,663,405 $ 1,111,795
EXPENSES:      
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below) 245,331 253,037 218,068
Research and development 245,326 270,806 272,702
Selling, general and administrative 645,238 689,751 590,751
Amortization of acquired intangible assets 1,101 35,689 36,363
Total expenses 1,136,996 1,249,283 1,117,884
OPERATING INCOME FROM CONTINUING OPERATIONS 420,636 414,122 (6,089)
OTHER INCOME (EXPENSE), NET:      
Interest income 42,450 30,854 7,629
Interest expense (22,578) (23,032) (13,040)
Change in the fair value of contingent consideration     (21,750)
Other income (expense), net 3,242 (425) 2,122
Total other income (expense), net 23,114 7,397 (25,039)
INCOME (LOSS) BEFORE INCOME TAXES 443,750 421,519 (31,128)
INCOME TAX PROVISION (BENEFIT) 71,612 (97,638) 2,024
NET INCOME (LOSS) FROM CONTINUING OPERATIONS 372,138 519,157 (33,152)
LOSS FROM DISCONTINUED OPERATIONS, NET OF TAX (5,068) (163,400) (125,115)
NET INCOME (LOSS) $ 367,070 $ 355,757 $ (158,267)
EARNINGS (LOSS) PER ORDINARY SHARE:      
Earnings (loss) per ordinary share from continuing operations - basic $ 2.25 $ 3.12 $ (0.2)
Loss per ordinary share from discontinued operations - basic (0.03) (0.98) (0.76)
Earnings (loss) per ordinary share - basic 2.22 2.14 (0.97)
Earnings (loss) per ordinary share from continuing operations - diluted 2.2 3.06 (0.2)
Loss per ordinary share from discontinued operations - diluted (0.03) (0.96) (0.76)
Earnings (loss) per ordinary share - diluted $ 2.17 $ 2.1 $ (0.97)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:      
Basic 165,392 166,223 163,742
Diluted 169,198 169,730 163,742
COMPREHENSIVE INCOME (LOSS) :      
Net income (loss) $ 367,070 $ 355,757 $ (158,267)
Holding gain (loss), net of a tax provision (benefit) of $292, $1,195 and $(973), respectively 1,143 7,779 (7,166)
COMPREHENSIVE INCOME (LOSS) 368,213 363,536 (165,433)
Product sales, net      
REVENUES:      
Total revenues 1,083,534 919,998 777,552
Manufacturing and royalty revenues      
REVENUES:      
Total revenues 474,095 743,388 331,983
License revenue      
REVENUES:      
Total revenues     2,000
Research and development revenue      
REVENUES:      
Total revenues $ 3 $ 19 $ 260