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CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Ordinary Shares
Additional Paid-In Capital
Accumulated Other Comprehensive Loss
Accumulated Deficit
Treasury Stock
BALANCE at Dec. 31, 2021 $ 1,112,584 $ 1,658 $ 2,798,325 $ (3,723) $ (1,541,018) $ (142,658)
BALANCE (in shares) at Dec. 31, 2021   165,790,549       (3,853,222)
Issuance of ordinary shares under employee stock plans 19,630 $ 32 19,598      
Issuance of ordinary shares under employee stock plans (in shares)   3,160,644        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (18,204)         $ (18,204)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (720,962)
Share-based compensation 95,176   95,176      
Unrealized gain (loss) on marketable securities, net of tax provision (benefit) (7,166)     (7,166)    
Net Income (Loss) (158,267)       (158,267)  
BALANCE at Dec. 31, 2022 1,043,753 $ 1,690 2,913,099 (10,889) (1,699,285) $ (160,862)
BALANCE (in shares) at Dec. 31, 2022   168,951,193       (4,574,184)
Issuance of ordinary shares under employee stock plans 16,760 $ 36 16,724      
Issuance of ordinary shares under employee stock plans (in shares)   3,617,858        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (28,474)         $ (28,474)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (1,015,034)
Share-based compensation 100,871   100,871      
Unrealized gain (loss) on marketable securities, net of tax provision (benefit) 7,779     7,779    
Distribution of Mural Oncology plc (293,760)   (293,760)      
Net Income (Loss) 355,757       355,757  
BALANCE at Dec. 31, 2023 1,202,686 $ 1,726 2,736,934 (3,110) (1,343,528) $ (189,336)
BALANCE (in shares) at Dec. 31, 2023   172,569,051       (5,589,218)
Issuance of ordinary shares under employee stock plans 27,572 $ 41 27,531      
Issuance of ordinary shares under employee stock plans (in shares)   4,101,734        
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (29,637)         $ (29,637)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)           (1,010,156)
Repurchase of Alkermes' ordinary shares $ (200,282)         $ (200,282)
Repurchase of Alkermes' ordinary shares (in shares) (7,900,000)         (7,894,417)
Share-based compensation $ 96,425   96,425      
Unrealized gain (loss) on marketable securities, net of tax provision (benefit) 1,143     1,143    
Net Income (Loss) 367,070       367,070  
BALANCE at Dec. 31, 2024 $ 1,464,977 $ 1,767 $ 2,860,890 $ (1,967) $ (976,458) $ (419,255)
BALANCE (in shares) at Dec. 31, 2024   176,670,785       (14,493,791)