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Income Taxes - Additional Information (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2021
Income Taxes [Line Items]        
Tax benefits included in discontinued operations $ 700 $ 1,400 $ 11,100  
Cumulative unremitted earnings of overseas subsidiaries 933,500      
Valuation allowance 79,727 129,296 $ 271,517 $ 249,112
State tax credits $ 34,000      
Minimum        
Income Taxes [Line Items]        
Period after loss carryforwards utilized that tax returns remain open to examination 3 years      
Maximum        
Income Taxes [Line Items]        
Period after loss carryforwards utilized that tax returns remain open to examination 4 years      
U.S. state        
Income Taxes [Line Items]        
Valuation allowance   $ 29,600    
Operating loss carryforwards $ 43,200      
U.S. state | Rodin Therapeutics Incorporation        
Income Taxes [Line Items]        
Operating loss carryforwards 5,800      
U.S. federal        
Income Taxes [Line Items]        
Operating loss carryforwards 14,100      
U.S. federal | Rodin Therapeutics Incorporation        
Income Taxes [Line Items]        
Operating loss carryforwards 14,100      
Federal research and development credits 500      
Ireland        
Income Taxes [Line Items]        
Income taxes payable on repatriation of unremitted earnings 72,000      
Valuation allowance 50,100      
Operating loss carryforwards $ 393,900      
EU        
Income Taxes [Line Items]        
Corporate minimum tax rate     15.00%  
Revenues     $ 750,000