<SEC-DOCUMENT>0000080255-25-000565.txt : 20250814
<SEC-HEADER>0000080255-25-000565.hdr.sgml : 20250814
<ACCEPTANCE-DATETIME>20250814130720
ACCESSION NUMBER:		0000080255-25-000565
CONFORMED SUBMISSION TYPE:	SCHEDULE 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250814
DATE AS OF CHANGE:		20250814

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Alkermes plc.
		CENTRAL INDEX KEY:			0001520262
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				981007018
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-86627
		FILM NUMBER:		251216795

	BUSINESS ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000
		BUSINESS PHONE:		00-353-1-772-8000

	MAIL ADDRESS:	
		STREET 1:		CONNAUGHT HOUSE
		STREET 2:		1 BURLINGTON ROAD
		CITY:			DUBLIN 4
		STATE:			L2
		ZIP:			00000

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ANTLER SCIENCE TWO PLC
		DATE OF NAME CHANGE:	20110804

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Antler Science Two Ltd
		DATE OF NAME CHANGE:	20110509

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PRICE T ROWE ASSOCIATES INC /MD/
		CENTRAL INDEX KEY:			0000080255
		STANDARD INDUSTRIAL CLASSIFICATION:	SECURITY & COMMODITY BROKERS, DEALERS, EXCHANGES & SERVICES [6200]
		ORGANIZATION NAME:           	09 Crypto Assets
		EIN:				520556948
		STATE OF INCORPORATION:			MD
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SCHEDULE 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		1307 POINT STREET
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21231
		BUSINESS PHONE:		(410)345-2000

	MAIL ADDRESS:	
		STREET 1:		P.O. BOX 89000
		CITY:			BALTIMORE
		STATE:			MD
		ZIP:			21289
</SEC-HEADER>
<DOCUMENT>
<TYPE>SCHEDULE 13G/A
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:ns2="http://www.sec.gov/edgar/common">
    <headerData>
        <submissionType>SCHEDULE 13G/A</submissionType>
        <previousAccessionNumber>0000080255-24-001364</previousAccessionNumber>
        <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0000080255</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
            <liveTestFlag>LIVE</liveTestFlag>


        </filerInfo>
    </headerData>
    <formData>
        <coverPageHeader>
            <amendmentNo>1</amendmentNo>
            <securitiesClassTitle>COMMON STOCK</securitiesClassTitle>
            <eventDateRequiresFilingThisStatement>06/30/2025</eventDateRequiresFilingThisStatement>
            <issuerInfo>
                <issuerCik>0001520262</issuerCik>
                <issuerName>ALKERMES PLC</issuerName>
                <issuerCusip>G01767105</issuerCusip>
                <issuerPrincipalExecutiveOfficeAddress>
                    <ns2:street1>CONNAUGHT HOUSE</ns2:street1>
                    <ns2:street2>1 BURLINGTON ROAD</ns2:street2>
                    <ns2:city>DUBLIN</ns2:city>
                    <ns2:stateOrCountry>L2</ns2:stateOrCountry>
                    <ns2:zipCode>0000</ns2:zipCode>
                </issuerPrincipalExecutiveOfficeAddress>
            </issuerInfo>
            <designateRulesPursuantThisScheduleFiled>
                <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
            </designateRulesPursuantThisScheduleFiled>
        </coverPageHeader>
        <coverPageHeaderReportingPersonDetails>

            <reportingPersonName>T. Rowe Price Associates, Inc.</reportingPersonName>
            <citizenshipOrOrganization>MD</citizenshipOrOrganization>
            <reportingPersonBeneficiallyOwnedNumberOfShares>
                <soleVotingPower>9983207</soleVotingPower>
                <sharedVotingPower>0</sharedVotingPower>
                <soleDispositivePower>10041900</soleDispositivePower>
                <sharedDispositivePower>0</sharedDispositivePower>
            </reportingPersonBeneficiallyOwnedNumberOfShares>
            <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>10041900</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
            <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
            <classPercent>6.1</classPercent>
            <typeOfReportingPerson>IA</typeOfReportingPerson>
        </coverPageHeaderReportingPersonDetails>
        <items>
            <item1>
                <issuerName>ALKERMES PLC</issuerName>
                <issuerPrincipalExecutiveOfficeAddress>CONNAUGHT HOUSE, 1 BURLINGTON ROAD, DUBLIN, L2, 0000</issuerPrincipalExecutiveOfficeAddress>
            </item1>
            <item2>
                <filingPersonName>T. Rowe Price Associates, Inc.</filingPersonName>
                <principalBusinessOfficeOrResidenceAddress>1307 Point Street, Baltimore, MD 21231</principalBusinessOfficeOrResidenceAddress>
                <citizenship>Maryland</citizenship>
            </item2>
            <item3>
                <notApplicableFlag>N</notApplicableFlag>
                <typeOfPersonFiling>IA</typeOfPersonFiling>
            </item3>
            <item4>
                <amountBeneficiallyOwned>10041900</amountBeneficiallyOwned>
                <classPercent>6.1</classPercent>
                <numberOfSharesPersonHas>
                    <solePowerOrDirectToVote>9983207</solePowerOrDirectToVote>
                    <sharedPowerOrDirectToVote>0</sharedPowerOrDirectToVote>
                    <solePowerOrDirectToDispose>10041900</solePowerOrDirectToDispose>
                    <sharedPowerOrDirectToDispose>0</sharedPowerOrDirectToDispose>
                </numberOfSharesPersonHas>
            </item4>
            <item5>
                <notApplicableFlag>Y</notApplicableFlag>
            </item5>
            <item6>
                <notApplicableFlag>Y</notApplicableFlag>
            </item6>
            <item7>
                <notApplicableFlag>Y</notApplicableFlag>
            </item7>
            <item8>
                <notApplicableFlag>Y</notApplicableFlag>
            </item8>
            <item9>
                <notApplicableFlag>Y</notApplicableFlag>
            </item9>
            <item10>
                <notApplicableFlag>N</notApplicableFlag>
                <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. T. Rowe Price Associates, Inc. hereby declares and affirms that the filing of Schedule 13G shall not be construed as an admission that Price Associates is the beneficial owner of the securities referred to, which beneficial ownership is expressly denied.</certifications>
            </item10>
        </items>
        <signatureInformation>
            <reportingPersonName>T. Rowe Price Associates, Inc.</reportingPersonName>
            <signatureDetails>
                <signature>Ellen York</signature>
                <title>Vice President</title>
                <date>08/14/2025</date>
            </signatureDetails>
        </signatureInformation>
    </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
