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Pay vs Performance Disclosure - USD ($) | 12 Months Ended
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Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Pay vs Performance Disclosure |  |  |  |  |
Pay vs Performance Disclosure, Table | Pay Versus Performance The disclosure included in this section is prescribed by SEC rules and does not necessarily align with how our Company or the Compensation Committee view the link between Company performance and executive compensation for our principal executive officer (“PEO”) and our non-PEO NEOs. For additional information about our pay-for-performance philosophy and how we align executive compensation with Company performance, see our Compensation Discussion and Analysis beginning on page 75 of this proxy statement. Tabular Disclosure of Pay Versus Performance The amounts set forth below under the headings “Compensation Actually Paid to PEO” and “Average Compensation Actually Paid to Non-PEO NEOs” have been calculated in a manner consistent with Item 402(v) of Regulation S-K. Use of the term “compensation actually paid” is required by the SEC’s rules and, as a result of the calculation methodology required by the SEC, such amounts differ from compensation actually earned, realized or received by the individuals and the compensation decisions described in our Compensation Discussion and Analysis beginning on page 75 of this proxy statement.
|  | Summary Compensation |  |  | Compensation Actually |  |  | Average Summary Compensation |  |  | Average Compensation Actually Paid to |  |  | Value of Initial Fixed $100 Investment Based on:(3) |  |  |  |  |  | EBITDA(4) from |
Year |  | Table Total for PEO(1) ($) |  |  | Paid to PEO(1)(2) ($) |  |  | Table Total for Non-PEO NEOs(1) ($) |  |  | Non-PEO NEOs(1)(2) ($) |  |  | TSR ($) |  |  | Peer Group TSR ($) |  |  | Net Income (Loss) ($ Millions) |  |  | Continuing Operations ($ Millions) |
(a) |  | (b) |  |  | (c) |  |  | (d) |  |  | (e) |  |  | (f) |  |  | (g) |  |  | (h) |  |  | (i) |
2024 |  |  | 10,131,193 |  |  |  | 14,626,813 |  |  |  | 3,897,805 |  |  |  | 4,740,491 |  |  |  | 143.27 |  |  |  | 118.20 |  |  |  | 367.1 |  |  |  | 452.4 |
2023 |  |  | 9,442,066 |  |  |  | 8,983,892 |  |  |  | 4,033,464 |  |  |  | 4,190,097 |  |  |  | 138.19 |  |  |  | 118.87 |  |  |  | 355.8 |  |  |  | 486.3 |
2022 |  |  | 10,314,172 |  |  |  | 8,321,591 |  |  |  | 4,155,421 |  |  |  | 4,206,760 |  |  |  | 128.09 |  |  |  | 113.65 |  |  |  | (158.3 | ) |  |  | 50.6 |
2021 |  |  | 8,846,588 |  |  |  | 11,225,263 |  |  |  | 2,942,671 |  |  |  | 2,882,217 |  |  |  | 114.02 |  |  |  | 126.45 |  |  |  | (48.2 | ) |  |  | 175.2 |
2020 |  |  | 8,041,702 |  |  |  | 6,883,292 |  |  |  | 2,882,616 |  |  |  | 2,656,656 |  |  |  | 97.79 |  |  |  | 126.42 |  |  |  | (110.9 | ) |  |  | (13.0 | )
(1) Richard F. Pops was our PEO for each year presented. The individuals comprising the non-PEO NEOs for each year presented are listed below.
2020 | 2021 | 2022 | 2023 | 2024
James M. Frates | Iain M. Brown | Iain M. Brown | Iain M. Brown | Iain M. Brown
David J. Gaffin | James M. Frates | David J. Gaffin | David J. Gaffin | Blair C. Jackson
Craig C. Hopkinson, M.D. | David J. Gaffin | Craig C. Hopkinson, M.D. | Craig C. Hopkinson, M.D. | David J. Gaffin
Michael J. Landine | Craig C. Hopkinson, M.D. | Blair C. Jackson | Blair C. Jackson | Craig C. Hopkinson, M.D.
| Blair C. Jackson |  |  | C. Todd Nichols
(2) For 2024, the amounts shown reflect the exclusion and inclusion of those certain amounts for the PEO and the non-PEO NEOs shown in the following tables. Equity values are calculated in accordance with ASC 718. Amounts shown in each of the Exclusion of Stock Awards and Option Awards columns are equal to the total amounts from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table on page 104 of this proxy statement.
Year |  | Summary Compensation Table Total for PEO ($) |  |  | Exclusion of Stock Awards and Option Awards for PEO ($) |  |  | Inclusion of Equity Values for PEO ($) |  |  | Compensation Actually Paid to PEO ($) |
2024 |  |  | 10,131,193 |  |  |  | (7,685,265 | ) |  |  | 12,180,885 |  |  |  | 14,626,813 |
Year |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
2024 |  |  | 3,897,805 |  |  |  | (2,943,554 | ) |  |  | 3,786,240 |  |  |  | 4,740,491 |
The amounts shown in the Inclusion of Equity Values column in the above tables are derived from the following amounts:
Year |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($) |  |  | Total - Inclusion of Equity Values for PEO* ($) |
2024 |  |  | 4,987,121 |  |  |  | 2,332,914 |  |  |  | 4,860,850 |  |  |  | — |  |  |  | 12,180,885 |
Year |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs* ($) |
2024 |  |  | 2,378,323 |  |  |  | 478,496 |  |  |  | 929,421 |  |  |  | — |  |  |  | 3,786,240 |
* The valuation assumptions used to calculate fair values did not materially differ from those disclosed at the time of grant. (3) The peer group TSR shown in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report. The comparison assumes $100 was invested in the Company and in the Nasdaq Biotechnology Index, respectively, for the period starting December 31, 2019 through the end of the year shown. Historical share price performance is not necessarily indicative of future share price performance. (4) We determined EBITDA from continuing operations to be the most important financial performance measure used to link Company performance to compensation actually paid to our PEO and non-PEO NEOs in 2024. The amount shown in this column for 2020 represents EBITDA rather than EBITDA from continuing operations, as following the separation in November 2023 of our former oncology business (which was classified as a discontinued operation in accordance with Financial Accounting Standards Board Accounting Standards Codification 205-20, or ASC 205-20, Discontinued Operations), applicable accounting guidance did not require that we calculate discontinued operations for fiscal years prior to 2021. See Appendix B for information regarding this non-GAAP financial measure. |  |  |  |
Company Selected Measure Name | EBITDA* from Continuing Operations |  |  |  |
Named Executive Officers, Footnote | (1) Richard F. Pops was our PEO for each year presented. The individuals comprising the non-PEO NEOs for each year presented are listed below.
2020 | 2021 | 2022 | 2023 | 2024
James M. Frates | Iain M. Brown | Iain M. Brown | Iain M. Brown | Iain M. Brown
David J. Gaffin | James M. Frates | David J. Gaffin | David J. Gaffin | Blair C. Jackson
Craig C. Hopkinson, M.D. | David J. Gaffin | Craig C. Hopkinson, M.D. | Craig C. Hopkinson, M.D. | David J. Gaffin
Michael J. Landine | Craig C. Hopkinson, M.D. | Blair C. Jackson | Blair C. Jackson | Craig C. Hopkinson, M.D.
| Blair C. Jackson |  |  | C. Todd Nichols
Peer Group Issuers, Footnote | (3) The peer group TSR shown in this table utilizes the Nasdaq Biotechnology Index, which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K included in our Annual Report. The comparison assumes $100 was invested in the Company and in the Nasdaq Biotechnology Index, respectively, for the period starting December 31, 2019 through the end of the year shown. Historical share price performance is not necessarily indicative of future share price performance. |  |  |  |
PEO Total Compensation Amount | $ 10,131,193 | $ 9,442,066 | $ 10,314,172 | $ 8,846,588 | $ 8,041,702
PEO Actually Paid Compensation Amount | $ 14,626,813 | 8,983,892 | 8,321,591 | 11,225,263 | 6,883,292
Adjustment To PEO Compensation, Footnote | (2) For 2024, the amounts shown reflect the exclusion and inclusion of those certain amounts for the PEO and the non-PEO NEOs shown in the following tables. Equity values are calculated in accordance with ASC 718. Amounts shown in each of the Exclusion of Stock Awards and Option Awards columns are equal to the total amounts from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table on page 104 of this proxy statement.
Year |  | Summary Compensation Table Total for PEO ($) |  |  | Exclusion of Stock Awards and Option Awards for PEO ($) |  |  | Inclusion of Equity Values for PEO ($) |  |  | Compensation Actually Paid to PEO ($) |
2024 |  |  | 10,131,193 |  |  |  | (7,685,265 | ) |  |  | 12,180,885 |  |  |  | 14,626,813 |
The amounts shown in the Inclusion of Equity Values column in the above tables are derived from the following amounts:
Year |  | Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for PEO ($) |  |  | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for PEO ($) |  |  | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for PEO ($) |  |  | Total - Inclusion of Equity Values for PEO* ($) |
2024 |  |  | 4,987,121 |  |  |  | 2,332,914 |  |  |  | 4,860,850 |  |  |  | — |  |  |  | 12,180,885 |
Non-PEO NEO Average Total Compensation Amount | $ 3,897,805 | 4,033,464 | 4,155,421 | 2,942,671 | 2,882,616
Non-PEO NEO Average Compensation Actually Paid Amount | $ 4,740,491 | 4,190,097 | 4,206,760 | 2,882,217 | 2,656,656
Adjustment to Non-PEO NEO Compensation Footnote | (2) For 2024, the amounts shown reflect the exclusion and inclusion of those certain amounts for the PEO and the non-PEO NEOs shown in the following tables. Equity values are calculated in accordance with ASC 718. Amounts shown in each of the Exclusion of Stock Awards and Option Awards columns are equal to the total amounts from the Stock Awards and Option Awards columns set forth in the Summary Compensation Table on page 104 of this proxy statement.
Year |  | Average Summary Compensation Table Total for Non-PEO NEOs ($) |  |  | Average Exclusion of Stock Awards and Option Awards for Non-PEO NEOs ($) |  |  | Average Inclusion of Equity Values for Non-PEO NEOs ($) |  |  | Average Compensation Actually Paid to Non-PEO NEOs ($) |
2024 |  |  | 3,897,805 |  |  |  | (2,943,554 | ) |  |  | 3,786,240 |  |  |  | 4,740,491 |
Year |  | Average Year-End Fair Value of Equity Awards Granted During Year That Remained Unvested as of Last Day of Year for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Last Day of Year of Unvested Equity Awards for Non-PEO NEOs ($) |  |  | Average Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards that Vested During Year for Non-PEO NEOs ($) |  |  | Average Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year for Non-PEO NEOs ($) |  |  | Total - Average Inclusion of Equity Values for Non-PEO NEOs* ($) |
2024 |  |  | 2,378,323 |  |  |  | 478,496 |  |  |  | 929,421 |  |  |  | — |  |  |  | 3,786,240 |
Compensation Actually Paid vs. Total Shareholder Return |  |  |  |  |
Compensation Actually Paid vs. Net Income |  |  |  |  |
Compensation Actually Paid vs. Company Selected Measure |  |  |  |  |
Tabular List, Table | The most important financial performance measures used to link compensation actually paid to our NEOs for 2024 to Company performance are set forth below. For further information regarding these performance metrics and their function in our executive compensation program, see our Compensation Discussion and Analysis beginning on page 75 of this proxy statement.
Proprietary Products Net Sales
Proprietary Products Profitability (Contribution Margin)
EBITDA* from Continuing Operations
EBITDA* Margin (EBITDA from Continuing Operations as a Percentage of Total Revenue)
NGNI* Margin (NGNI from Continuing Operations as a Percentage of Total Revenue)
Relative Total Shareholder Return
* See Appendix B for information regarding this non-GAAP financial target. |  |  |  |
Total Shareholder Return Amount | $ 143.27 | 138.19 | 128.09 | 114.02 | 97.79
Peer Group Total Shareholder Return Amount | 118.2 | 118.87 | 113.65 | 126.45 | 126.42
Net Income (Loss) | $ 367,100,000 | $ 355,800,000 | $ (158,300,000) | $ (48,200,000) | $ (110,900,000)
Company Selected Measure Amount | 452,400,000 | 486,300,000 | 50,600,000 | 175,200,000 | (13,000,000)
PEO Name | Richard F. Pops | Richard F. Pops | Richard F. Pops | Richard F. Pops | Richard F. Pops
Measure:: 1 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Proprietary Products Net Sales |  |  |  |
Measure:: 2 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Proprietary Products Profitability (Contribution Margin) |  |  |  |
Measure:: 3 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | EBITDA* from Continuing Operations |  |  |  |
Non-GAAP Measure Description | (4) We determined EBITDA from continuing operations to be the most important financial performance measure used to link Company performance to compensation actually paid to our PEO and non-PEO NEOs in 2024. The amount shown in this column for 2020 represents EBITDA rather than EBITDA from continuing operations, as following the separation in November 2023 of our former oncology business (which was classified as a discontinued operation in accordance with Financial Accounting Standards Board Accounting Standards Codification 205-20, or ASC 205-20, Discontinued Operations), applicable accounting guidance did not require that we calculate discontinued operations for fiscal years prior to 2021. See Appendix B for information regarding this non-GAAP financial measure. |  |  |  |
Measure:: 4 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | EBITDA* Margin (EBITDA from Continuing Operations as a Percentage of Total Revenue) |  |  |  |
Measure:: 5 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | NGNI* Margin (NGNI from Continuing Operations as a Percentage of Total Revenue) |  |  |  |
Measure:: 6 |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Name | Relative Total Shareholder Return |  |  |  |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ 12,180,885 |  |  |  |
PEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (7,685,265) |  |  |  |
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 4,987,121 |  |  |  |
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 2,332,914 |  |  |  |
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 4,860,850 |  |  |  |
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 3,786,240 |  |  |  |
Non-PEO NEO | Equity Awards Adjustments, Excluding Value Reported in Compensation Table |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | (2,943,554) |  |  |  |
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 2,378,323 |  |  |  |
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | 478,496 |  |  |  |
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |  |
Pay vs Performance Disclosure |  |  |  |  |
Adjustment to Compensation, Amount | $ 929,421 |  |  |  |

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