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Fair Value Measurements - Fair Value Inputs, Liabilities, Quantitative Information (Details) $ in Thousands | Dec. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Dec. 31, 2016 USD ($)
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Contingent Consideration |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Contingent consideration liability | $ 82,236 | $ 10,956 | $ 683
Revenue-based Payments | Contingent Consideration |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Contingent consideration liability | 10,661 | 10,956 |
Supply chain milestone | Contingent Consideration |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Contingent consideration liability | 13,593 |  |
Revenue milestones |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Contingent consideration liability | 57,982 |  |
Other Payments |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Contingent consideration asset | $ 607 |  |
Other Payments | Contingent Consideration |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Contingent consideration asset |  | $ 760 |
Measurement Input, Discount Rate | Revenue-based Payments | Minimum | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent liability | 0.099 | 0.099 |
Measurement Input, Discount Rate | Revenue-based Payments | Maximum | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent liability | 0.25 | 0.15 |
Measurement Input, Discount Rate | Supply chain milestone | Contingent Consideration | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent liability | 0.053 |  |
Measurement Input, Discount Rate | Revenue milestones | Minimum | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent liability | 0.03 |  |
Measurement Input, Discount Rate | Revenue milestones | Maximum | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent liability | 0.13 |  |
Measurement Input, Discount Rate | Other Payments | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent receivable asset | 0.10 |  |
Measurement Input, Discount Rate | Other Payments | Contingent Consideration | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent receivable asset |  | 0.10 |
Milestone Payment Probability | Supply chain milestone | Contingent Consideration | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent liability | 0.95 |  |
Milestone Payment Probability | Other Payments | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent receivable asset | 0.67 |  |
Milestone Payment Probability | Other Payments | Contingent Consideration | Discounted Cash Flow | Fair Value, Inputs, Level 3 |  |  |
Fair Value Measurements Inputs and Valuation Techniques [Line Items] |  |  |
Unobservable inputs, contingent receivable asset |  | 0.75 |

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