<SEC-DOCUMENT>0001654954-16-004586.txt : 20161205
<SEC-HEADER>0001654954-16-004586.hdr.sgml : 20161205
<ACCEPTANCE-DATETIME>20161205163021
ACCESSION NUMBER:		0001654954-16-004586
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20161205
ITEM INFORMATION:		Other Events
FILED AS OF DATE:		20161205
DATE AS OF CHANGE:		20161205

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TG THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001001316
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				363898269
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-32639
		FILM NUMBER:		162034143

	BUSINESS ADDRESS:	
		STREET 1:		787 SEVENTH AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019
		BUSINESS PHONE:		(212) 554-4484

	MAIL ADDRESS:	
		STREET 1:		787 SEVENTH AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10019

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MANHATTAN PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20030310

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ATLANTIC TECHNOLOGY VENTURES INC
		DATE OF NAME CHANGE:	20000330

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ATLANTIC PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	19960703
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>v120516_8k.htm
<DESCRIPTION>FORM 8-K
<TEXT>
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<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">UNITED STATES</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">SECURITIES AND EXCHANGE
COMMISSION</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">WASHINGTON, D.C.</font> <font style="font-weight: bold"><font style="font-size: 13px">20549</font></font></font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">FORM 8-K</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">_____________</font></font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">CURRENT REPORT</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Pursuant to Section 13 or 15(d) of
the</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Securities Exchange Act of
1934</font></font></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Date of report
(Date of earliest event reported): <font style="font-weight: bold">December 5, 2016</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"></div>
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<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">TG Therapeutics, Inc.</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Exact Name of
Registrant as Specified in Charter)</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
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<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Delaware</font></font></div>
<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(State or Other
Jurisdiction</font></div>
<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">of
Incorporation)</font></div>
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<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">001-32639</font></font></div>
<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Commission File
Number)</font></div>
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<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">36-3898269</font></font></div>
<div style="text-align: center; margin-left: 12px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(IRS Employer
Identification No.)</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 19px; text-indent: 0px"></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">2 Gansevoort Street, 9<font style="vertical-align: super; font-size: 70%">th</font>
Floor</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">New York, New York 10014</font></font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Address of
Principal Executive Offices)</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: center; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">(212) 554-4484</font></font></div>
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appropriate box below if the Form 8-K filing is intended to
simultaneously satisfy the filing obligation of the registrant
under any of the following provisions:</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>Written communications pursuant to Rule 425
under the Securities Act.</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>Soliciting material pursuant to Rule 14a-12
under the Exchange Act.</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>Pre-commencement communications pursuant to Rule
14d-2b under the Exchange Act.</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>Pre-commencement communications pursuant to Rule
13e-4(c) under the Exchange Act.</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Item 8.01. Other Events.</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">&#xA0;</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 19px; text-indent: 48px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-family: Times New Roman; font-size: 13px">On December 5,
2016, TG Therapeutics, Inc. issued press releases announcing
certain data regarding preclinical and clinical studies of TGR-1202
at the 58th American Society of Hematology (ASH) annual meeting in
San Diego, CA. Copies of the press releases are being filed as
Exhibits 99.1 and 99.2 and incorporated in this Item by
reference</font>.<br></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 48px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Item 9.01 Financial Statements And
Exhibits.</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(d)
Exhibits.</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: left; margin-left: 48px; margin-right: 0px; text-indent: -48px"><font style="font-size: 13px; font-family: Times New Roman">99.1&#xA0; Press
Release, dated December 5, 2016.</font></div>
<div style="text-align: left; margin-left: 48px; margin-right: 0px; text-indent: -48px"><font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 48px; margin-right: 0px; text-indent: -48px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-size: 13px; font-family: Times New Roman">99.2&#xA0; Press
Release, dated December 5, 2016</font><br></font></div>
<div style="text-align: center; margin-left: 48px; margin-right: 0px; text-indent: -48px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">SIGNATURES</font></font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 19px; text-indent: 0px"></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 48px"><font style="font-size: 13px; font-family: Times New Roman">Pursuant to the
requirements of the Securities Exchange Act of 1934, the registrant
has duly caused this report to be signed on its behalf by the
undersigned hereunto duly authorized.</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 50%; text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">TG Therapeutics, Inc.</font></font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">(Registrant)</font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
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<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Date: December 5,
2016</font></div>
</td>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
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<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">By:&#xA0;<font style="text-decoration: underline">/s/
Sean A.
Power&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Sean A.
Power</font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Chief Financial
Officer</font></div>
</td>
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<td style="text-indent: 0; padding-bottom: 0px">
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</tr></table>
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</div>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
<div style="text-align: center; margin-left: 336px; margin-right: 19px; text-indent: -336px"><font style="font-weight: bold; font-size: 13px; font-family: Times New Roman">INDEX
TO EXHIBITS</font></div>
<div style="text-align: justify; margin-left: 0px; margin-right: 19px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">&#xA0;</font></font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px;">
<table cellpadding="0" cellspacing="0" style="text-align: left; width: 100%; font-size: 13px; font-family: Times New Roman">
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<td style="width: 9%; text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 1%; text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="width: 90%; text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold">Exhibit</font></font></div>
</td>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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<td style="text-indent: 0; padding-bottom: 0px; text-decoration: underline">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold"><font style="text-decoration: underline">Number</font></font></font></div>
</td>
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</td>
<td style="text-indent: 0; padding-bottom: 0px; text-decoration: underline">
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman"><font style="font-weight: bold"><font style="text-decoration: underline">Description</font></font></font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">99.1.</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">Press Release,
dated December 5, 2016</font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font><font style="font-size: 13px; font-family: Times New Roman">99.2</font><br></font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font><font style="font-size: 13px; font-family: Times New Roman">Press Release,
dated December 5, 2016</font><br></font></div>
</td>
</tr><tr style="vertical-align: top">
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
<td style="text-indent: 0; padding-bottom: 0px">
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
</td>
</tr></table>
</div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font style="font-size: 13px; font-family: Times New Roman">&#xA0;</font></div>
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<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px"><font>&#xA0;</font></div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>v120516_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
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<font style="font-family: Times New Roman; font-size: 11px">&#xA0;
<font style="font-weight: bold"><font style="font-size: 13px">Exhibit 99.1</font></font><br></font></div>
</div>
</div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">TG
Therapeutics, Inc. Announces Preclinical Data Presentations for
TGR-1202 at the 58<font style="font-size: 70%; vertical-align: top">th</font> American Society of
Hematology Annual Meeting</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
Preclinical work may offer rationale for the differentiated
activity and safety effects of TGR-1202</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">SAN
DIEGO, CA (December 5, 2016) - TG Therapeutics, Inc. (NASDAQ:TGTX),
announced the presentation yesterday of two preclinical data sets,
one oral presentation and one poster presentation, for TGR-1202,
the Company&#x2019;s once-daily PI3K delta inhibitor, at the
58<font style="font-size: 70%; vertical-align: top">th</font>
American Society of Hematology (ASH) annual meeting in San Diego,
California.</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Michael
S. Weiss, the Company's Executive Chairman and Interim Chief
Executive Officer, stated, "We want to thank the teams at Columbia
and Moffitt for their extensive laboratory work on TGR-1202 to
better understand the mechanism of action and impact on the immune
system. The preclinical data they have generated helps to better
explain and perhaps offer a rationale for the differentiated safety
profile seen with TGR-1202 as compared to earlier generation PI3K
delta inhibitors. We believe these preclinical findings along with
the robust safety and efficacy data we have observed in the clinic,
support our belief that TGR-1202 is a differentiated best in class
PI3K delta inhibitor. We look forward to continuing our research
collaborations with Columbia and Moffitt and to presenting updated
safety and efficacy data for TGR-1202 to further confirm its unique
profile.&#x201D;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#x201C;Dr. Deng's
presentation today has really begun to shed some long-needed light
on the important differences among the PI3K delta inhibitors. His
work has identified that a novel kinase important in the PI3K
pathway, CK-1epsilon, is uniquely inhibited by TGR-1202, which may
explain the drug&#x2019;s effects on c-Myc. These chemical
differences may also help to explain the important immunologic
differences in the safety profiles of these agents,&#x201D; stated
<font style="color: #333333">Dr. Owen A. O&#x2019;Connor, Professor
of Medicine and Experimental Therapeutics, Director Lymphoid
Malignancies at Columbia Presbyterian Medical
Center.</font></font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
following summarizes the oral presentation and poster presentation
which occurred yesterday:</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
<font style="text-decoration: underline">Oral Presentation:</font>
Silencing c-Myc Translation as a Therapeutic Strategy through
Targeting PI3K Delta and CK1 Epsilon in Hematological Malignancies
(Abstract Number 291)</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">This
oral presentation includes data from the manuscript titled,
&#x201C;Silencing c-Myc Translation as a Therapeutic Strategy
through Targeting PI3K Delta and CK1 Epsilon in Hematological
Malignancies,&#x201D; which was recently published in <font style="font-style: italic">Blood,</font> the Journal of the American
Society of Hematology. The presentation was delivered by Changchung
Deng, MD, PhD of Columbia Presbyterian Medical Center and included
the following highlights:</font></div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TGR-1202 and
carfilzomib, but not combinations of other drugs in the same
classes, synergistically inhibit c-Myc translation and c-Myc
dependent gene transcription, by potently inhibiting
phosphorylation of 4E-BP1;</font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TGR-1202 and
carfilzomib synergistically induce apoptosis in lymphoma cells
through targeting c-Myc, whereas the other combinations did
not;</font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;&#xA0;&#xA0;&#xA0;<br></font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TGR-1202, but not
idelalisib or duvelisib, was found to uniquely inhibit <font style="color: #333333">casein kinase-1 (CK1) epsilon;
and</font></font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;&#xA0;&#xA0;&#xA0;<br></font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px;"><font style="font-family: Times New Roman; font-size: 13px">Based on this
extensive preclinical work, the Company recently announced the
launch of a Phase 1/2 study to evaluate the safety and efficacy of
TGR-1202 in combination with carfilzomib, in patients with relapsed
or refractory lymphoma.</font><br></font></div>
</div>
</div>
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<div style="text-align: right; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
</div>
<div style="text-align: left; padding-bottom: 8px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
<font style="text-decoration: underline">Poster
Presentation:</font> Modulation of T Cell Compartment in a
Preclinical CLL Murine Model By a Selective PI3K Delta Inhibitor,
TGR-1202 (Abstract Number 3236)</font></div>
<div style="text-align: left; padding-bottom: 8px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">This
poster presentation included preclinical data describing the
differential regulation of human T-cells by TGR-1202 in a
preclinical CLL murine model. Highlights from this poster
include:</font></div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Both TGR-1202 and
duvelisib oral<font style="font-style: italic">&#xA0;</font>administration demonstrated
comparable efficacy by reducing CLL burden over time in leukemic
mice;</font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TGR-1202 and
duvelisib both targeted the T cell population <font style="font-style: italic">in vivo</font>, however:</font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TGR-1202 relatively
maintained the number of Tregs and Th17 cells and expression of
functional markers on Tregs compared to duvelisib treatment
<font style="font-style: italic">in vivo</font> and <font style="font-style: italic">ex vivo</font>; and</font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Duvelisib resulted
in greater disruption of Treg/Th17 ratio compared to TGR-1202
<font style="font-style: italic">in vivo</font>, which may have
implications for occurrence of autoimmune-like organ
toxicity.</font></div>
</div>
</div>
<div style="text-align: justify; padding-bottom: 8px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; font-weight: bold; font-family: Times New Roman; font-size: 13px">
PRESENTATION DETAILS:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 13px">Copies of the above referenced presentations are
available on the Company&#x2019;s website at</font> <font style="text-decoration: underline; color: #0000FF; font-size: 13px">www.tgtherapeutics.com</font><font style="font-size: 13px">,
located on the Publications page.</font></font></div>
<div style="text-align: left; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
TG THERAPEUTICS INVESTOR &amp; ANALYST EVENT DETAILS:</font></div>
<div style="text-align: left; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">TG Therapeutics will also host an investor and
analyst reception on Monday, December 5</font><font style="font-size: 70%; vertical-align: top; color: #000000">th</font><font style="color: #000000">,
2016 beginning at 8:00pm PT. The event will take place at the
Marriott Gaslamp, in San Diego, California, in the Presidio AB
Ballroom.</font></font></div>
<div style="text-align: left; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; font-style: italic; color: #000000; font-size: 13px">
NOTE:</font> <font style="font-style: italic; color: #000000; font-size: 13px">This event
will be webcast live and will be available on the Events page,
located within the Investors &amp; Media section of the
Company&#x2019;s website at</font> <font style="font-style: italic; text-decoration: underline; color: #0000FF; font-size: 13px">
www.tgtherapeutics.com</font><font style="font-style: italic; color: #000000; font-size: 13px">, as well as
archived for future review. This event will also be broadcast via
conference call.&#xA0; In order to access the conference line,
please call 1-877-407-8029 (U.S.), 1-201-689-8029 (outside the
U.S.), and reference Conference Title: TG Therapeutics 2016
Investor &amp; Analyst Event.</font> <font style="color: #000000; font-size: 13px">&#xA0;</font></font></div>
<div style="text-align: justify; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">ABOUT
TG THERAPEUTICS, INC.</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">TG
Therapeutics is a biopharmaceutical company focused on the
acquisition, development and commercialization of novel treatments
for B-cell malignancies and autoimmune diseases. Currently, the
company is developing two therapies targeting hematological
malignancies and autoimmune diseases. TG-1101 (ublituximab) is a
novel, glycoengineered monoclonal antibody that targets a specific
and unique epitope on the CD20 antigen found on mature
B-lymphocytes. TG Therapeutics is also developing TGR-1202, an
orally available PI3K delta inhibitor. The delta isoform of PI3K is
strongly expressed in cells of hematopoietic origin and is believed
to be important in the proliferation and survival of
B&#x2010;lymphocytes. Both TG-1101 and TGR-1202 are in clinical
development for patients with hematologic malignancies, with
TG-1101 recently entering clinical development for autoimmune
disorders. The Company also has pre-clinical programs to develop
IRAK4 inhibitors, BET inhibitors, and anti-PD-L1 and anti-GITR
antibodies. TG Therapeutics is headquartered in New York
City.</font></div>
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<div id="hdr">
<div style="text-align: right; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
</div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Cautionary
Statement</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Some of
the statements included in this press release, particularly those
with respect to anticipating future clinical trials, the timing of
commencing or completing such trials and business prospects for
TG-1101, TGR-1202, the IRAK4 inhibitor program, the BET inhibitor
program, and the anti-PD-L1 and anti-GITR antibodies may be
forward-looking statements that involve a number of risks and
uncertainties. For those statements, we claim the protection of the
safe harbor for forward-looking statements contained in the Private
Securities Litigation Reform Act of 1995. Among the factors that
could cause our actual results to differ materially are the
following: our ability to successfully and cost-effectively
complete preclinical and clinical trials for TG-1101, TGR-1202, the
IRAK4 inhibitor program, the BET inhibitor program, and the
anti-PD-L1 and anti-GITR antibodies; the risk that early
preclinical and clinical results that supported our decision to
move forward with TG-1101, TGR-1202, the IRAK4 inhibitor program,
the BET inhibitor program, and the anti-PD-L1 and anti-GITR
antibodies will not be reproduced in additional patients or in
future studies; the risk that trends observed which underlie
certain assumptions of future performance of TGR-1202 will not
continue, the risk that TGR-1202 will not produce satisfactory
safety and efficacy results to warrant further development
following the completion of the current Phase 1 study; the risk
that the combination of TG-1101 and TGR-1202, referred to as
TG-1303, will not prove to be a safe and efficacious backbone for
triple and quad combination therapies; the risk that the data (both
safety and efficacy) from future clinical trials will not coincide
with the data produced from prior preclinical and clinical trials;
the risk that trials will take longer to enroll than expected; our
ability to achieve the milestones we project over the next year;
our ability to manage our cash in line with our projections, and
other risk factors identified from time to time in our reports
filed with the Securities and Exchange Commission. Any
forward-looking statements set forth in this press release speak
only as of the date of this press release. We do not undertake to
update any of these forward-looking statements to reflect events or
circumstances that occur after the date hereof. This press release
and prior releases are available at www.tgtherapeutics.com. The
information found on our website is not incorporated by reference
into this press release and is included for reference purposes
only.</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">TGTX -
G</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">CONTACT:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 48px">
<font style="font-family: Times New Roman; font-size: 13px">Jenna
Bosco</font></div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 48px"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Vice President,
Investor Relations</font></div>
</div>
</div>
<div style="display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 48px"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TG Therapeutics,
Inc.</font></div>
</div>
</div>
<div style="display: table">
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<div style="display: table-cell; width: 48px"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Telephone:
212.554.4351</font></div>
</div>
</div>
<div style="padding-bottom: 13.3px; display: table">
<div style="display: table-row">
<div style="display: table-cell; width: 48px"><font style="font-family: Times New Roman; font-size: 13px">&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;&#xA0;</font></div>
<div style="text-align: left; display: table-cell"><font style="font-size: 13px; font-family: Times New Roman">Email:
ir@tgtxinc.com</font></div>
</div>
</div>
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<DOCUMENT>
<TYPE>EX-99.2
<SEQUENCE>3
<FILENAME>v120516_ex99-2.htm
<DESCRIPTION>EXHIBIT 99.2
<TEXT>
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<font style="font-family: Times New Roman; font-size: 11px">&#xA0;<font style="font-weight: bold"><font style="font-size: 13px">Exhibit
99.2</font></font></font></div>
</div>
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<div style="text-align: justify; padding-bottom: 10.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 11px;">&#xA0;</font></div>
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<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">TG
Therapeutics, Inc. Announces Oral Data Presentation for TGR-1202 in
Combination with Ibrutinib in Patients with Relapsed or Refractory
CLL or MCL at the 58<font style="font-size: 70%; vertical-align: top">th</font> American Society of
Hematology Annual Meeting</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
Combination of TGR-1202 plus ibrutinib is well-tolerated with no
Grade 3/4 transaminitis, pneumonitis, diarrhea, or colitis
observed, with patients approaching two years on
therapy</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-style: italic; font-family: Times New Roman; font-size: 13px">
88% ORR in CLL patients, including 1 CR, and 73% ORR in MCL
patients treated with the combination</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">SAN
DIEGO, CA (December 5, 2016) - TG Therapeutics, Inc. (NASDAQ:TGTX),
today announced the presentation of combination data from a Phase
1b study evaluating TGR-1202, the Company&#x2019;s once-daily PI3K
delta inhibitor, in combination with ibrutinib, the oral
Bruton&#x2019;s tyrosine kinase (BTK). This study is being run in
collaboration with the Blood Cancer Research Partnership (BCRP) and
Dana-Farber Cancer Institute (DFCI), Boston, MA. Data from this
trial were presented today by the Principal Investigator, Matthew
S. Davids, MD, of Dana-Farber Cancer Institute, during an oral
session at the 58<font style="font-size: 70%; vertical-align: top">th</font> American Society of
Hematology (ASH) annual meeting in San Diego, CA.</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Michael
S. Weiss, the Company&#x2019;s Executive Chairman and Interim CEO
commenting on the data said, &#x201C;We and our investigators
continue to be impressed with the ease of combining TGR-1202 with
other novel agents. Here Dr. Davids demonstrated that the double
blockade of the BCR pathway with dual oral once-daily inhibitors
can be performed safely and conveniently, and derives high response
rates in patients with both CLL and MCL. This all oral approach
offers a unique and highly active alternative for patients who do
not want to receive infused therapies but still want to advance
their treatment beyond single agent ibrutinib, which may offer
multiple benefits over single agent therapy. With one bone marrow
confirmed complete response (CR) and 5 additional deep responses
nearing radiographic CR out of the 17 evaluable CLL patients, we
and our investigators believe we are seeing activity beyond what
one might expect from either of these agents alone. We want to
thank Dr. Davids and his collaborators at DFCI and the Leukemia
&amp; Lymphoma Society for providing support for this important
investigator driven research and we look forward to follow-up data
in the future from this study and data from our own triple therapy
of TG-1101 plus TGR-1202 plus ibrutinib, which we are targeting for
presentation next year.&#x201D;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">The
following summarizes the key highlights from this oral presentation
which occurred today:</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-style: italic; font-family: Times New Roman; font-size: 13px">
<font style="text-decoration: underline">Oral Presentation:</font>
TGR-1202 in Combination with Ibrutinib in Patients with Relapsed or
Refractory CLL or MCL: Preliminary Results of a Multicenter Phase
I/Ib Study (Abstract Number 641)</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">This
oral presentation includes data from patients with relapsed or
refractory chronic lymphocytic leukemia (CLL) or mantle cell
lymphoma (MCL) treated with TGR-1202 in combination with Ibrutinib.
31 patients were evaluable for safety (18 CLL patients and 13 MCL
patients), of which 28 patients were available for efficacy (17 CLL
patients and 11 MCL patients.) CLL patients had a median of 1.5
prior lines of therapy (range 1-6), with 2 patients receiving prior
ibrutinib and 4 receiving prior PI3K inhibitors. MCL patients had a
median of 3 prior lines of therapy (range 2-5), also with 2
patients receiving prior ibrutinib.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Highlights
from this oral presentation include:</font></div>
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<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="color: #000000; font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">88%
(15 of 17) Overall Response Rate (ORR) (including Complete Response
(CR), Partial Response (PR), and Partial Response with
lymphocytosis (PR-L)) in patients with CLL, with 1 patient
achieving a bone marrow confirmed CR and 5 patients with a &gt;80%
nodal reduction, nearing radiographic CR</font></div>
</div>
</div>
<div style="padding-top: 6.7px; ; padding-bottom: 6.7px; ; margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="color: #000000; font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">1
year progression free survival (PFS) and overall survival (OS) for
CLL is 94% (n=17), with the longest patient on study approaching
two years</font></div>
</div>
</div>
<div style="padding-top: 6.7px; ; padding-bottom: 6.7px; ; margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="color: #000000; font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">73%
(8/11) ORR in patients with MCL, with clinical benefit observed in
two additional patients</font></div>
</div>
</div>
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<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="color: #000000; font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">1
year PFS and OS for MCL is 37% and 52%, respectively
(n=11)</font></div>
</div>
</div>
<div style="margin-left: 24px; display: table">
<div style="display: table-row">
<div style="text-align: left; display: table-cell; width: 24px">
<font style="color: #000000; font-size: 13px">&#x25CF;</font></div>
<div style="text-align: justify; display: table-cell"><font style="color: #000000; font-family: Times New Roman; font-size: 13px">The
combination appears well tolerated across all patients with no
grade 3/4 transaminitis (liver toxicity), diarrhea, colitis or
pneumonitis observed</font></div>
</div>
</div>
<div style="text-align: justify; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; font-weight: bold; font-family: Times New Roman; font-size: 13px">
PRESENTATION DETAILS:</font></div>
<div style="text-align: left; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px;">&#xA0;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-size: 13px">The above referenced presentation is available on
the Company&#x2019;s website at</font> <font style="text-decoration: underline; color: #0000FF; font-size: 13px">www.tgtherapeutics.com</font><font style="font-size: 13px">,
located on the Publications page.</font></font></div>
<div style="text-align: left; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="text-decoration: underline; color: #000000; font-weight: bold; font-family: Times New Roman; font-size: 13px">
TG THERAPEUTICS INVESTOR &amp; ANALYST EVENT DETAILS:</font></div>
<div style="text-align: left; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="color: #000000">TG Therapeutics will also host an investor and
analyst reception on Monday, December 5</font><font style="font-size: 70%; vertical-align: top; color: #000000">th</font><font style="color: #000000">,
2016 beginning at 8:00pm PT. The event will take place at the
Marriott Gaslamp, in San Diego, California, in the Presidio AB
Ballroom.</font></font></div>
<div style="text-align: left; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px"><font style="font-weight: bold; font-style: italic; color: #000000; font-size: 13px">
NOTE:</font> <font style="font-style: italic; color: #000000; font-size: 13px">This event
will be webcast live and will be available on the Events page,
located within the Investors &amp; Media section of the
Company&#x2019;s website at</font> <font style="font-style: italic; text-decoration: underline; color: #0000FF; font-size: 13px">
www.tgtherapeutics.com</font><font style="font-style: italic; color: #000000; font-size: 13px">, as well as
archived for future review. This event will also be broadcast via
conference call.&#xA0; In order to access the conference line,
please call 1-877-407-8029 (U.S.), 1-201-689-8029 (outside the
U.S.), and reference Conference Title: TG Therapeutics 2016
Investor &amp; Analyst Event.</font> <font style="color: #000000; font-size: 13px">&#xA0;</font></font></div>
<div style="text-align: justify; padding-top: 6.7px; padding-bottom: 6.7px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">ABOUT
TG THERAPEUTICS, INC.</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">TG
Therapeutics is a biopharmaceutical company focused on the
acquisition, development and commercialization of novel treatments
for B-cell malignancies and autoimmune diseases. Currently, the
company is developing two therapies targeting hematological
malignancies and autoimmune diseases. TG-1101 (ublituximab) is a
novel, glycoengineered monoclonal antibody that targets a specific
and unique epitope on the CD20 antigen found on mature
B-lymphocytes. TG Therapeutics is also developing TGR-1202, an
orally available PI3K delta inhibitor. The delta isoform of PI3K is
strongly expressed in cells of hematopoietic origin and is believed
to be important in the proliferation and survival of
B&#x2010;lymphocytes. Both TG-1101 and TGR-1202 are in clinical
development for patients with hematologic malignancies, with
TG-1101 recently entering clinical development for autoimmune
disorders. The Company also has pre-clinical programs to develop
IRAK4 inhibitors, BET inhibitors, and anti-PD-L1 and anti-GITR
antibodies. TG Therapeutics is headquartered in New York
City.</font></div>
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<div style="text-align: right; width: 100%"><font style="font-family: Times New Roman; font-size: 11px">&#xA0;</font></div>
</div>
</div>
<div style="text-align: justify; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">&#xA0;</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-weight: bold; font-family: Times New Roman; font-size: 13px">Cautionary
Statement</font></div>
<div style="text-align: left; padding-bottom: 13.3px; margin-left: 0px; margin-right: 0px; text-indent: 0px">
<font style="font-family: Times New Roman; font-size: 13px">Some of
the statements included in this press release, particularly those
with respect to anticipating future clinical trials, the timing of
commencing or completing such trials and business prospects for
TG-1101, TGR-1202, the IRAK4 inhibitor program, the BET inhibitor
program, and the anti-PD-L1 and anti-GITR antibodies may be
forward-looking statements that involve a number of risks and
uncertainties. For those statements, we claim the protection of the
safe harbor for forward-looking statements contained in the Private
Securities Litigation Reform Act of 1995. Among the factors that
could cause our actual results to differ materially are the
following: our ability to successfully and cost-effectively
complete preclinical and clinical trials for TG-1101, TGR-1202, the
IRAK4 inhibitor program, the BET inhibitor program, and the
anti-PD-L1 and anti-GITR antibodies; the risk that early
preclinical and clinical results that supported our decision to
move forward with TG-1101, TGR-1202, the IRAK4 inhibitor program,
the BET inhibitor program, and the anti-PD-L1 and anti-GITR
antibodies will not be reproduced in additional patients or in
future studies; the risk that trends observed which underlie
certain assumptions of future performance of TGR-1202 will not
continue, the risk that TGR-1202 will not produce satisfactory
safety and efficacy results to warrant further development
following the completion of the current Phase 1 study; the risk
that the combination of TG-1101 and TGR-1202, referred to as
TG-1303, will not prove to be a safe andefficacious backbone for
triple and quad combination therapies; the risk that the data (both
safety and efficacy) from future clinical trials will not coincide
with the data produced from prior preclinical and clinical trials;
the risk that trials will take longer to enroll than expected; our
ability to achieve the milestones we project over the next year;
our ability to manage our cash in line with our projections, and
other risk factors identified from time to time in our reports
filed with the Securities and Exchange Commission. Any
forward-looking statements set forth in this press release speak
only as of the date of this press release. We do not undertake to
update any of these forward-looking statements to reflect events or
circumstances that occur after the date hereof. This press release
and prior releases are available at www.tgtherapeutics.com. The
information found on our website is not incorporated by reference
into this press release and is included for reference purposes
only.</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">TGTX -
G</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">CONTACT:</font></div>
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<font style="font-family: Times New Roman; font-size: 13px">Jenna
Bosco</font></div>
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<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Vice President,
Investor Relations</font></div>
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<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">TG Therapeutics,
Inc.</font></div>
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<div style="text-align: left; display: table-cell"><font style="font-family: Times New Roman; font-size: 13px">Telephone:
212.554.4351</font></div>
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<div style="text-align: left; display: table-cell"><font style="font-size: 13px; font-family: Times New Roman">Email:
ir@tgtxinc.com</font></div>
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