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INCOME TAXES (Details) - USD ($) | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | --- | ---
Deferred tax assets (liabilities): |  |  |
Net operating loss carryforwards | $ 83,655,879 | $ 95,329,928 |
Research and development credit | 10,490,793 | 7,326,715 |
Noncash compensation | 4,933,807 | 12,915,672 |
Other | 632,274 | 599,514 |
Deferred tax asset, excluding valuation allowance | 99,712,753 | 116,171,829 |
Less valuation allowance | (99,712,753) | (116,171,829) | $ (86,358,850)
Net deferred tax assets | $ 0 | $ 0 |

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