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ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative) - USD ($) | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Accounting Policies [Abstract] |  |  |
Accumulated deficit | $ (354,862,832) | $ (236,386,820) |
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount | 4,835,706 | 8,033,779 | 7,064,396
Restricted Cash and Investments | $ 600,000 | $ 600,000 |
Prepaid Manufacturing | $ 8,100,000 | $ 5,700,000 |

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