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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES |  |  |
Consolidated net loss | $ (118,476,012) | $ (78,252,894) | $ (62,948,646)
Adjustments to reconcile consolidated net loss to net cash used in operating activities: |  |  |
Gain on sale of long-term securities | 0 | (33,042) | 0
Noncash stock compensation expense | 15,945,284 | 7,509,999 | 15,697,092
Depreciation | 82,355 | 62,960 | 15,452
Amortization of premium on investment securities | 61,320 | 459,429 | 536,142
Change in fair value of notes payable and accrued interest | 58,739 | (109,657) | (56,717)
Changes in assets and liabilities: |  |  |
Increase in restricted cash | (4,083) | (4,065) | (4,131)
Decrease (increase) in other current assets | (2,665,222) | 3,564,316 | (3,105,771)
Decrease (increase) in leasehold interest | 124,947 | (2,042,281) | 0
(Increase) decrease in accrued interest receivable | (24,616) | 102,169 | (100,505)
Decrease (increase) in other assets | 161,730 | (4,784) | (41,722)
Increase (decrease) in accounts payable and accrued expenses | 11,020,034 | 6,492,644 | 5,470,915
Increase in deferred rent | 104,343 | 816,257 | 0
Decrease in deferred revenue | (152,381) | (152,381) | (152,381)
Net cash used in operating activities | (93,763,562) | (61,591,330) | (44,690,272)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |
Purchases of equipment | (2,227) | (343,985) | (42,217)
Investment in held-to-maturity securities | (28,006,270) | (15,199,922) | (48,993,652)
Proceeds from maturity of short-term securities | 19,800,000 | 29,500,000 | 24,350,000
Proceeds from the sale of long-term securities | 0 | 12,589,219 | 0
Net cash provided by (used in) investing activities | (8,208,497) | 26,545,312 | (24,685,869)
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |
Proceeds from the exercise of warrants | 2,143,085 | 618,242 | 1,067,339
Proceeds from sale of common stock, net | 131,515,541 | 4,411,233 | 67,760,517
Deferred financing costs paid | 0 | (13,506) | (104,170)
Net cash provided by financing activities | 133,658,626 | 5,015,969 | 68,723,686
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS | 31,686,567 | (30,030,049) | (652,455)
Cash and cash equivalents at beginning of year | 25,031,280 | 55,061,329 | 55,713,784
CASH AND CASH EQUIVALENTS AT END OF YEAR | 56,717,847 | 25,031,280 | 55,061,329
NONCASH TRANSACTIONS |  |  |
Reclassification of deferred financing costs to additional paid-in capital | (2,645) | (25,097) | (111,810)
Conversion of convertible notes payable to common stock | $ 0 | $ 33,017 | $ 6,924

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