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Consolidated Statements of Operations - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Statement [Abstract] |  |  |
License revenue | $ 152,381 | $ 152,381 | $ 152,381
Research and development: |  |  |
Noncash compensation | 5,646,716 | 2,742,354 | 4,261,406
Other research and development | 96,886,134 | 66,489,820 | 43,445,817
Total research and development | 102,532,850 | 69,232,174 | 47,707,223
General and administrative: |  |  |
Noncash compensation | 10,298,568 | 4,767,645 | 11,435,686
Other general and administrative | 6,032,714 | 5,121,690 | 4,189,488
Total general and administrative | 16,331,282 | 9,889,335 | 15,625,174
Total costs and expenses | 118,864,132 | 79,121,509 | 63,332,397
Operating loss | (118,711,751) | (78,969,128) | (63,180,016)
Other (income) expense: |  |  |
Interest income | (294,478) | (323,032) | (174,653)
Other (income) expense | 58,739 | (393,202) | (56,717)
Total other income, net | (235,739) | (716,234) | (231,370)
Net loss | $ (118,476,012) | $ (78,252,894) | $ (62,948,646)
Basic and diluted net loss per common share (in dollars per share) | $ (1.91) | $ (1.60) | $ (1.38)
Weighted average shares used in computing basic and diluted net loss per common share (in shares) | 62,069,570 | 49,041,354 | 45,646,414

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