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INCOME TAXES (Details 1) - USD ($) | 12 Months Ended
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Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Tax Disclosure [Abstract] |  |  |
Loss before income taxes, as reported in the consolidated statements of operations | $ (118,476,012) | $ (78,252,894) | $ (62,948,646)
Computed "expected" tax benefit | (40,281,844) | (26,605,984) | (21,402,540)
Increase (decrease) in income taxes resulting from: |  |  |
Expected benefit from state and local taxes | (1,105,708) | (835,072) | (672,306)
Research and development credits | (3,697,258) | (2,364,417) | (1,603,364)
Other | 1,563,114 | (7,506) | 566,310
Impact of change in state tax rates on deferred taxes | 0 | 0 | 5,836,819
Stock awards | 8,213,188 | 0 | 0
Effects of federal tax reform rate changes | 51,767,584 | 0 | 0
Change in the balance of the valuation allowance for deferred tax assets | (16,459,076) | 29,812,979 | 17,275,081
Income Tax Expense (Benefit) | $ 0 | $ 0 | $ 0

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