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INCOME TAXES (Tables) | 12 Months Ended
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Dec. 31, 2017
Income Tax Disclosure [Abstract] |
Schedule of Deferred Tax Assets and Liabilities |
|  | 2017 |  |  | 2016 |
Deferred tax assets (liabilities): |  |  |  |  |  |
Net operating loss carryforwards |  | $ | 83,655,879 |  |  | $ | 95,329,928 |
Research and development credit |  |  | 10,490,793 |  |  |  | 7,326,715 |
Noncash compensation |  |  | 4,933,807 |  |  |  | 12,915,672 |
Other |  |  | 632,274 |  |  |  | 599,514 |
Deferred tax asset, excluding valuation allowance |  |  | 99,712,753 |  |  |  | 116,171,829 |
Less valuation allowance |  |  | (99,712,753 | ) |  |  | (116,171,829 | )
Net deferred tax assets |  | $ | -- |  |  | $ | -- |
Schedule of Effective Income Tax Rate Reconciliation |
|  | 2017 |  |  | 2016 |  |  | 2015 |
Loss before income taxes, as reported in the consolidated statements of operations |  | $ | (118,476,012 | ) |  | $ | (78,252,894 | ) |  | $ | (62,948,646 | )
Computed “expected” tax benefit |  | $ | (40,281,844 | ) |  | $ | (26,605,984 | ) |  | $ | (21,402,540 | )
Increase (decrease) in income taxes resulting from: |  |  |  |  |  |  |  |  |  |  |  |
Expected benefit from state and local taxes |  |  | (1,105,708 | ) |  |  | (835,072 | ) |  |  | (672,306 | )
Research and development credits |  |  | (3,697,258 | ) |  |  | (2,364,417 | ) |  |  | (1,603,364 | )
Other |  |  | 1,563,114 |  |  |  | (7,506 | ) |  |  | 566,310 |
Impact of change in state tax rates on deferred taxes |  |  | -- |  |  |  | -- |  |  |  | 5,836,819 |
Stock awards |  |  | 8,213,188 |  |  |  |  |  |  |  |  |
Effects of federal tax reform rate changes |  |  | 51,767,584 |  |  |  |  |  |  |  |  |
Change in the balance of the valuation allowance for deferred tax assets |  |  | (16,459,076) |  |  |  | 29,812,979 |  |  |  | 17,275,081 |
|  | $ | -- |  |  | $ | -- |  |  | $ | -- |

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- Definition Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32537-109319 + Details
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- Definition Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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