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Consolidated Statements of Equity - USD ($) $ in Thousands | Common Stock [Member] | Contingently Issuable Share [Member] | Additional Paid-in Capital [Member] | Treasury Stock [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | --- | --- | ---
Balance at Dec. 31, 2015 | $ 54 |  | $ 259,887 | $ (234) | $ (158,134) | $ 101,573
Balance (in shares) at Dec. 31, 2015 | 54,095,110 | 6 |  | 41,309 |  |
Issuance of common stock in connection with exercise of warrants |  |  | 618 |  |  | 618
Issuance of common stock in connection with exercise of warrants (in shares) | 273,370 |  |  |  |  |
Issuance of common stock in connection with conversion of notes payable |  |  | 33 |  |  | 33
Issuance of common stock in connection with conversion of notes payable (in shares) | 3,710 |  |  |  |  |
Issuance of restricted stock | $ 2 |  | (2) |  |  |
Issuance of restricted stock (in shares) | 1,924,639 |  |  |  |  |
Forfeiture of restricted stock (in shares) | (46,773) |  |  |  |  |
Issuance of common stock in At-the-Market offering (net of offering costs) |  |  | 4,386 |  |  | 4,386
Issuance of common stock in At-the-Market offering (net of offering costs) (in shares) | 570,366 |  |  |  |  |
Compensation in respect of restricted stock granted to employees, directors and consultants |  |  | 7,510 |  |  | 7,510
Adjustment to contingently issuable shares |  | $ (6) |  |  |  |
Net loss |  |  |  |  | (78,253) | (78,253)
Balance at Dec. 31, 2016 | $ 57 |  | 272,432 | $ (234) | (236,387) | 35,868
Balance (in shares) at Dec. 31, 2016 | 56,820,422 | 0 |  | 41,309 |  |
Issuance of common stock in connection with exercise of warrants |  |  | 2,142 |  |  | 2,143
Issuance of common stock in connection with exercise of warrants (in shares) | 887,585 |  |  |  |  |
Issuance of restricted stock | $ 2 |  | (2) |  |  |
Issuance of restricted stock (in shares) | 1,836,511 |  |  |  |  |
Forfeiture of restricted stock (in shares) | (53,875) |  |  |  |  |
Issuance of common stock in public offering (net of offering costs of $3.6 million) | $ 6 |  | 53,634 |  |  | 53,640
Issuance of common stock in public offering (net of offering costs of $3.6 million) (in shares) | 5,897,436 |  |  |  |  |
Issuance of common stock in At-the-Market offering (net of offering costs) | $ 8 |  | 77,865 |  |  | 77,873
Issuance of common stock in At-the-Market offering (net of offering costs) (in shares) | 7,793,671 |  |  |  |  |
Compensation in respect of restricted stock granted to employees, directors and consultants |  |  | 15,945 |  |  | 15,945
Net loss |  |  |  |  | (118,476) | (118,476)
Balance at Dec. 31, 2017 | $ 73 |  | 422,017 | $ (234) | (354,863) | 66,993
Balance (in shares) at Dec. 31, 2017 | 73,181,750 | 0 |  | 41,309 |  |
Issuance of restricted stock | $ 2 |  | (2) |  |  |
Issuance of restricted stock (in shares) | 1,562,211 |  |  |  |  |
Forfeiture of restricted stock (in shares) | (191,196) |  |  |  |  |
Issuance of common stock in At-the-Market offering (net of offering costs) | $ 9 |  | 113,630 |  |  | 113,639
Issuance of common stock in At-the-Market offering (net of offering costs) (in shares) | 9,025,222 |  |  |  |  |
Compensation in respect of restricted stock granted to employees, directors and consultants |  |  | 12,886 |  |  | 12,886
Shares issued in connection with in-licensing agreements |  |  | 4,000 |  |  | 4,000
Shares issued in connection with in-licensing agreements (in shares) | 333,868 |  |  |  |  |
Net loss |  |  |  |  | (173,482) | (173,482)
Balance at Dec. 31, 2018 | $ 84 |  | $ 552,531 | $ (234) | $ (528,345) | $ 24,036
Balance (in shares) at Dec. 31, 2018 | 83,911,855 | 0 |  | 41,309 |  |

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