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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES |  |  |
Consolidated net loss | $ (173,482) | $ (118,476) | $ (78,253)
Adjustments to reconcile consolidated net loss to net cash used in operating activities: |  |  |
Gain on sale of long-term securities | 0 | 0 | (33)
Noncash stock compensation expense | 12,886 | 15,945 | 7,510
Shares issued in connection with in-licensing agreement | 4,000 | 0 | 0
Depreciation | 88 | 82 | 63
Amortization of premium on investment securities | (119) | 61 | 459
Change in fair value of notes payable and accrued interest | (61) | 59 | (110)
Changes in assets and liabilities: |  |  |
(Increase) decrease in other current assets | (1,638) | (2,665) | 3,565
Decrease (increase) in leasehold interest | 135 | 125 | (2,042)
Decrease (increase) in accrued interest receivable | 14 | (25) | 102
Decrease (increase) in other assets | 0 | 162 | (5)
Increase in accounts payable and accrued expenses | 10,957 | 11,020 | 6,493
Increase in other liabilities | 18,350 | 0 | 0
Increase in deferred rent | 97 | 104 | 816
Decrease in deferred revenue | (152) | (152) | (152)
Net cash used in operating activities | (128,925) | (93,760) | (61,587)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |
Proceeds from maturity of short-term securities | 32,500 | 19,800 | 29,500
Investment in held-to-maturity securities | (31,230) | (28,006) | (15,200)
Purchases of equipment | (90) | (2) | (344)
Proceeds from the sale of long-term securities | 0 | 0 | 12,589
Net cash provided by (used in) investing activities | 1,180 | (8,208) | 26,545
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |
Proceeds from sale of common stock, net | 113,639 | 131,516 | 4,411
Proceeds from the exercise of warrants | 0 | 2,143 | 618
Deferred financing costs paid | 0 | 0 | (13)
Net cash provided by financing activities | 113,639 | 133,659 | 5,016
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS | (14,106) | 31,691 | (30,026)
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF YEAR | 57,305 | 25,614 | 55,640
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF YEAR | 43,199 | 57,305 | 25,614
Reconciliation to amounts on consolidated balance sheets: |  |  |
Total cash, cash equivalents and restricted cash | 43,199 | 57,305 | 25,614
NONCASH TRANSACTIONS |  |  |
Reclassification of deferred financing costs to additional paid-in capital | 0 | (3) | (25)
Conversion of convertible notes payable to common stock | $ 0 | $ 0 | $ 33

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