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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES      
Consolidated net loss $ (173,482) $ (118,476) $ (78,253)
Adjustments to reconcile consolidated net loss to net cash used in operating activities:      
Gain on sale of long-term securities 0 0 (33)
Noncash stock compensation expense 12,886 15,945 7,510
Shares issued in connection with in-licensing agreement 4,000 0 0
Depreciation 88 82 63
Amortization of premium on investment securities (119) 61 459
Change in fair value of notes payable and accrued interest (61) 59 (110)
Changes in assets and liabilities:      
(Increase) decrease in other current assets (1,638) (2,665) 3,565
Decrease (increase) in leasehold interest 135 125 (2,042)
Decrease (increase) in accrued interest receivable 14 (25) 102
Decrease (increase) in other assets 0 162 (5)
Increase in accounts payable and accrued expenses 10,957 11,020 6,493
Increase in other liabilities 18,350 0 0
Increase in deferred rent 97 104 816
Decrease in deferred revenue (152) (152) (152)
Net cash used in operating activities (128,925) (93,760) (61,587)
CASH FLOWS FROM INVESTING ACTIVITIES      
Proceeds from maturity of short-term securities 32,500 19,800 29,500
Investment in held-to-maturity securities (31,230) (28,006) (15,200)
Purchases of equipment (90) (2) (344)
Proceeds from the sale of long-term securities 0 0 12,589
Net cash provided by (used in) investing activities 1,180 (8,208) 26,545
CASH FLOWS FROM FINANCING ACTIVITIES      
Proceeds from sale of common stock, net 113,639 131,516 4,411
Proceeds from the exercise of warrants 0 2,143 618
Deferred financing costs paid 0 0 (13)
Net cash provided by financing activities 113,639 133,659 5,016
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS (14,106) 31,691 (30,026)
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF YEAR 57,305 25,614 55,640
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF YEAR 43,199 57,305 25,614
Reconciliation to amounts on consolidated balance sheets:      
Total cash, cash equivalents and restricted cash 43,199 57,305 25,614
NONCASH TRANSACTIONS      
Reclassification of deferred financing costs to additional paid-in capital 0 (3) (25)
Conversion of convertible notes payable to common stock $ 0 $ 0 $ 33