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Condensed Consolidated Statements of Operations - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2021
Sep. 30, 2020
Revenue:        
Total revenue $ 2,030 $ 38 $ 4,368 $ 114
Costs and expenses:        
Cost of product revenue 292   580  
Research and development:        
Noncash compensation 4,534 4,618 19,061 8,150
Other research and development 47,433 45,846 140,872 114,785
Total research and development 51,967 50,464 159,933 122,935
Selling, general and administrative:        
Noncash compensation 9,463 23,712 27,857 38,618
Other selling, general and administrative 25,436 11,584 67,821 25,373
Total selling, general and administrative 34,899 35,296 95,678 63,991
Total costs and expenses 87,158 85,760 256,191 186,926
Operating loss (85,128) (85,722) (251,823) (186,812)
Other expense (income):        
Interest expense 1,038 1,610 4,559 5,038
Other income (529) (169) (1,619) (687)
Total other expense (income), net 509 1,441 2,940 4,351
Net loss $ (85,637) $ (87,163) $ (254,763) $ (191,163)
Basic and diluted net loss per common share (in dollars per share) $ (0.65) $ (0.73) $ (1.93) $ (1.70)
Weighted average shares used in computing basic and diluted net loss per common share (in shares) 132,353,119 119,176,336 132,109,912 112,380,784
Product revenue, net [Member]        
Revenue:        
Total revenue $ 1,992   $ 4,254  
License revenue [Member]        
Revenue:        
Total revenue $ 38 $ 38 $ 114 $ 114