Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (109,523)	$ (169,125)
Adjustments to reconcile net loss to net cash used in operating activities:
Noncash stock compensation expense	1,146	32,922
Depreciation and amortization	154	126
Amortization of premium on investment securities	(17)	282
Amortization of debt issuance costs	922	463
Amortization of leasehold interest	106	106
Noncash change in lease liability and right of use asset	1,014	949
Change in fair value of notes payable	(276)	(221)
Changes in assets and liabilities:
Decrease (increase) in other current assets	8,054	(4,421)
Decrease (increase) in accounts receivable	1,301	(931)
(Decrease) increase in accounts payable and accrued expenses	(21,355)	3,271
Decrease in lease liabilities	(995)	(1,006)
Increase (decrease) in other current liabilities	1,740	(3,863)
Decrease in deferred revenue	(76)	(76)
Net cash used in operating activities	(117,805)	(141,524)
CASH FLOWS FROM INVESTING ACTIVITIES
Proceeds from maturity of short-term securities	38,525	28,750
Investment in held-to-maturity securities	(71,810)	(31,497)
Purchases of PPE	(7)	(242)
Net cash used in investing activities	(33,292)	(2,989)
CASH FLOWS FROM FINANCING ACTIVITIES
Payment of loan payable	(975)	(7,200)
Proceeds from exercise of options	260	166
Offering costs paid		(183)
Net cash used in financing activities	(715)	(7,217)
NET DECREASE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH	(151,812)	(151,730)
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT BEGINNING OF PERIOD	300,151	554,698
CASH, CASH EQUIVALENTS AND RESTRICTED CASH AT END OF PERIOD	$ 148,339	$ 402,968

The change in fair value of notes payable during the period.

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