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Note 8 - Leases (Details Textual)
$ in Thousands
 1 Months Ended 3 Months Ended
Oct. 31, 2021
USD ($)
Oct. 31, 2014
USD ($)
ft²
Mar. 31, 2025
USD ($)
Dec. 31, 2024
USD ($)
Mar. 31, 2024
USD ($)
Dec. 31, 2021
Feb. 28, 2019
Restricted Cash     $ 1,302   $ 1,289    
Operating Lease, Liability     8,976 [1] $ 9,290      
Operating Lease, Right-of-Use Asset     $ 6,927 $ 7,151      
Operating Lease, Weighted Average Remaining Lease Term (Year)     5 years 4 months 24 days        
Operating Lease, Weighted Average Discount Rate, Percent     10.04%       10.25%
Operating Lease, Payments     $ 500        
The North Carolina Lease [Member]              
Average Annual Rental Payments $ 200            
Operating Lease, Expense     $ 100        
Operating Lease, Weighted Average Discount Rate, Percent           5.65%  
Office Agreement with Fortress Biotech [Member]              
Percentage of Occupancy   45.00%          
Area of Real Estate Property (Square Foot) | ft²   24,000          
Lessee, Operating Lease, Term of Contract (Year)   15 years          
Average Annual Rental Payments   $ 1,800          
Office Agreement with Fortress Biotech [Member] | Deposit for Office Agreement [Member]              
Restricted Cash   $ 1,300          
Office Agreement [Member]              
Lessee, Operating Lease, Renewal Term (Year) 5 years   2 years        
Operating Lease, Liability     $ 9,000        
Operating Lease, Right-of-Use Asset     $ 6,900        
Office Agreement [Member] | Minimum [Member]              
Lessee, Operating Lease, Remaining Lease Term (Year)     2 years        
Office Agreement [Member] | Maximum [Member]              
Lessee, Operating Lease, Remaining Lease Term (Year)     6 years        
[1] As our leases do not provide an implicit rate, we use our incremental borrowing rate based on the information available at commencement date and considering the term of the lease to determine the present value of lease payments. We used the incremental borrowing rate of 10.25% on February 28, 2019, for operating leases that commenced prior to that date through December 31, 2021. We used an incremental borrowing rate of 5.65% for the NC lease.