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Statement of Cash Flow (Parenthetical) (Detail) (USD $) |  | 1 Months Ended |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Apr. 23, 2008 | Oct. 21, 2011 Roche [Member] | Apr. 05, 2012 Alvos acquisition [Member] | Mar. 23, 2005 Insert Therapeutics, Inc [Member] | Feb. 28, 2010 Calando Pharmaceuticals, Inc. [Member] | Nov. 30, 2009 Calando Pharmaceuticals, Inc. [Member] | Mar. 31, 2006 Calando Pharmaceuticals, Inc. [Member] | Sep. 30, 2010 Calando Pharmaceuticals, Inc. [Member] Series A Preferred Stock [Member] | Apr. 29, 2008 MASA Energy LLC [Member]
Purchase of common shares | 200,000 |  |  | 7,375,000 | 200,000 | 2,850,000 | 964,000 | 1,562.5 |
Common stock, shares issued | 7,054 |  |  | 50,226 | 8,000 | 114,000 | 20,838 |  | 10,504
Common stock value |  |  |  | $ 2,000,000 |  | $ 706,800 | $ 1,077,333 |  | $ 310,000
Value of common stock purchased |  |  |  |  |  |  | 1,928,000 |  | 560,000
Stock purchased by cash | 200,000 |  |  |  |  |  | 850,667 |  | 250,000
Warrants issued |  |  |  |  | 2,400 | 24,000 |  | 390,625 |
Warrants purchased |  |  |  |  | 60,000 | 600,000 |  |  |
Common stock exercise value |  |  |  |  | $ 5.00 |  |  | $ 5.00 |
Shares exchanged as part of acquisition |  | 1,288,158 | 315,457 |  |  |  |  |  |
Issue of promissory note to Roche |  | $ 50,000 |  |  |  |  |  |  |

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- Definition Total number of common shares of an entity that have been sold or granted to shareholders (includes common shares that were issued, repurchased and remain in the treasury). These shares represent capital invested by the firm's shareholders and owners, and may be all or only a portion of the number of shares authorized. Shares issued include shares outstanding and shares held in the treasury. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.29) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher SEC -Name Regulation S-X (SX) -Number 210 -Section 02 -Paragraph 30 -Article 5 + Details
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- Definition The number of shares issued as [noncash or part noncash] consideration for a business or asset acquired. Noncash is defined as transactions during a period that affect recognized assets or liabilities but that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4313-108586 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Statement of Financial Accounting Standard (FAS) -Number 95 -Paragraph 32 -LegacyDoc This reference is SUPERSEDED by the Accounting Standards Codification effective for interim and annual periods ending after September 15, 2009. This reference is included to help users transition from the previous accounting hierarchy and will be removed from future versions of this taxonomy. + Details
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