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Stockholders' Equity - Additional Information (Detail) (USD $)
 1 Months Ended 12 Months Ended 125 Months Ended 1 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended
May 31, 2013
Jan. 31, 2013
Dec. 31, 2012
Aug. 10, 2012
Sep. 30, 2013
Sep. 30, 2012
Sep. 30, 2011
Sep. 30, 2010
Sep. 30, 2013
Oct. 21, 2011
Nov. 17, 2011
Roche
Feb. 29, 2012
Series A Preferred Stock
Oct. 31, 2011
Series A Preferred Stock
Oct. 21, 2011
Series A Preferred Stock
May 31, 2013
Series B convertible preferred stock
Sep. 30, 2013
Limited liability company
Oct. 31, 2011
Subscription Agreement
Oct. 31, 2011
Subscription Agreement
Series A Preferred Stock
May 31, 2013
Common Stock
Oct. 31, 2011
Common Stock
Sep. 30, 2011
Common Stock
Sep. 30, 2013
Common Stock
Sep. 30, 2012
Common Stock
Sep. 30, 2011
Common Stock
Sep. 30, 2010
Common Stock
Sep. 30, 2005
Common Stock
Oct. 21, 2011
Common Stock
Oct. 04, 2011
Common Stock
Sep. 30, 2013
2000 Stock Option Plan
Sep. 30, 2013
2004 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]                                                            
Capital stock authorized for issuance         150,000,000       150,000,000                                          
Common stock, shares authorized         145,000,000 145,000,000     145,000,000                                          
Common stock, par value         $ 0.001 $ 0.001     $ 0.001 $ 0.001                                        
Preferred stock, shares authorized         5,000,000 5,000,000     5,000,000                                          
Preferred stock, par value         $ 0.001 $ 0.001     $ 0.001     $ 0.001   $ 0.001                                
Common stock, shares outstanding         32,489,444 13,579,185     32,489,444                                          
Preferred stock, shares outstanding         9,900 0     9,900                                          
Share reserve for issuance                                                         153,200 3,419,285
Threshold percentage of common stock ownership upon preferred stock conversion         9.99%       9.99%                                          
Issuance and sold of stock   1,667,051 1,825,079 2,260,869                     9,900   675,000 1,015 14,300,000.0 138,158 1,191,473 1,182,451 15,511 8,656 225,189 1,250        
Sale of stock, price per share   $ 2.12 $ 2.26 $ 2.76                   $ 1,000 $ 1,000       $ 1.83   $ 3.80     $ 3.80     $ 3.70 $ 3.80    
Proceeds from issuance of common stock, preferred stock and warrants, net   $ 3,500,000 $ 4,100,000 $ 6,200,000 $ 44,506,004 $ 10,958,231     $ 150,759,015                     $ 525,000 $ 4,500,000                  
Maximum equity commitment amount under agreement                               15,000,000                            
Equity commitment agreement period                               36 months                            
Cash drawn from facility                               1,000,000                            
Aggregate purchase price of preferred shares             1,618,509 300,000         1,015,000                                  
Number of shares converted in common stock                       1,015 1,015                                  
Preferred stock converted to common stock, shares                       275,782                                    
Aggregate purchase price on issuance of common stock to be received                                       2,497,500                    
Unit sold, description   Each unit consisted of one share of common stock and a warrant to purchase Each unit consisted of one share of common stock and a warrant to purchase Each unit consisted of one share of common stock and a warrant to purchase                                                    
Warrant to purchase common stock   0.5 0.5 0.75                                                    
Common stock exercise price       $ 3.25                                                    
Reverse stock split ratio                     0.1                                      
Exercise prices         1.83       1.83                                          
Warrant to purchase share of Common Stock   0.5 0.5 0.75                                                    
Conversion price $ 1.83                                                          
Shares issued under public offering, value $ 36,000,000       $ 44,500,000