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Investment in Subsidiaries - Additional Information (Detail) (USD $) | 3 Months Ended | 12 Months Ended |  |  |  | 12 Months Ended |
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Dec. 31, 2012 | Sep. 30, 2011 | Jan. 31, 2011 Preferred Stock B and C [Member] | Dec. 31, 2012 Calando Pharmaceuticals, Inc. [Member] | Jan. 31, 2011 Calando Pharmaceuticals, Inc. [Member] | Sep. 30, 2011 Ablaris Therapeutics, Inc. [Member] | Dec. 31, 2012 Ablaris Therapeutics, Inc. [Member] | Dec. 31, 2012 Leonardo Biosystems, Inc. [Member]
Schedule of Investments [Line Items] |  |  |  |  |  |  |  |
Ownership percentage in subsidiary | 100.00% |  |  |  |  |  |  |
Investment in preferred stock |  |  | $ 9,100,000 |  |  | $ 1,300,000 |  |
Cash investment in subsidiary |  |  |  |  | 1,000,000 |  |  |
Investment in subsidiary through conversion of intercompany debt |  |  |  |  | 8,100,000 |  |  |
Amount owed by subsidiary |  |  |  | 3,500,000 |  |  |  | 575,000
Stated percentage of notes and advances |  |  |  | 800000000.00% |  |  |  |
Percentage of outstanding shares |  |  |  | 7900.00% |  |  | 64.00% | 3.00%
Percentage of investment ownership |  |  |  | 76.00% |  |  | 64.00% |
Aggregate purchase price of preferred shares |  | (1,618,509) |  |  |  | 2,900,000 |  |
Investment in preferred stock by outsider |  |  |  |  |  | $ 1,600,000 |  |

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