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Investment in Subsidiaries - Additional Information (Detail) (USD $)	3 Months Ended	12 Months Ended				12 Months Ended
	Dec. 31, 2012	Sep. 30, 2011	Jan. 31, 2011 Preferred Stock B and C [Member]	Dec. 31, 2012 Calando Pharmaceuticals, Inc. [Member]	Jan. 31, 2011 Calando Pharmaceuticals, Inc. [Member]	Sep. 30, 2011 Ablaris Therapeutics, Inc. [Member]	Dec. 31, 2012 Ablaris Therapeutics, Inc. [Member]	Dec. 31, 2012 Leonardo Biosystems, Inc. [Member]
Schedule of Investments [Line Items]
Ownership percentage in subsidiary	100.00%
Investment in preferred stock			$ 9,100,000			$ 1,300,000
Cash investment in subsidiary					1,000,000
Investment in subsidiary through conversion of intercompany debt					8,100,000
Amount owed by subsidiary				3,500,000				575,000
Stated percentage of notes and advances				800000000.00%
Percentage of outstanding shares				7900.00%			64.00%	3.00%
Percentage of investment ownership				76.00%			64.00%
Aggregate purchase price of preferred shares		(1,618,509)				2,900,000
Investment in preferred stock by outsider						$ 1,600,000

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Cash investment in subsidiary.

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Investment in preferred stock.

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Investment in subsidiary through conversion of intercompany debt.

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Ownership percentage in subsidiary.

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