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Stockholders' Equity - Additional Information (Detail) (USD $) | 0 Months Ended | 1 Months Ended | 3 Months Ended | 12 Months Ended | 128 Months Ended |  | 1 Months Ended | 3 Months Ended | 12 Months Ended | 1 Months Ended |  | 0 Months Ended | 1 Months Ended | 3 Months Ended |
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Oct. 11, 2013 | May 31, 2013 | Jan. 31, 2013 | Dec. 31, 2012 | Aug. 10, 2012 | Dec. 31, 2013 | Dec. 31, 2012 | Sep. 30, 2011 | Sep. 30, 2010 | Dec. 31, 2013 | Sep. 30, 2013 | Nov. 17, 2011 Roche | May 31, 2013 Common Stock | Dec. 31, 2013 Common Stock | Sep. 30, 2013 Common Stock | Sep. 30, 2012 Common Stock | Sep. 30, 2011 Common Stock | Sep. 30, 2010 Common Stock | Sep. 30, 2005 Common Stock | Feb. 29, 2012 Series A Preferred Stock | Oct. 31, 2011 Series A Preferred Stock | Oct. 21, 2011 Series A Preferred Stock | Oct. 11, 2013 Series C Preferred Stock | May 31, 2013 Series B convertible preferred stock | Oct. 31, 2011 Subscription Agreement | Oct. 31, 2011 Subscription Agreement Series A Preferred Stock | Dec. 31, 2013 Limited liability company | Dec. 31, 2013 2004 Equity Incentive Plan, 2000 Stock Option Plan, and Inducement Grants
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Capital stock authorized for issuance |  |  |  |  |  | 150,000,000 |  |  |  | 150,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, shares authorized |  |  |  |  |  | 145,000,000 |  |  |  | 145,000,000 | 145,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock, par value |  |  |  |  |  | $ 0.001 |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 0.001 |  |  |
Preferred stock, shares authorized |  |  |  |  |  | 5,000,000 |  |  |  | 5,000,000 | 5,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, par value |  |  |  |  |  | $ 0.001 |  |  |  | $ 0.001 | $ 0.001 |  |  |  |  |  |  |  |  | $ 0.001 |  | $ 0.001 |  |  |  |  |  |
Common stock, shares outstanding |  |  |  |  |  | 39,002,152 |  |  |  | 39,002,152 | 32,489,444 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock, shares outstanding |  |  |  |  |  | 51,291 |  |  |  | 51,291 | 9,900 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Share reserve for issuance |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,451,210
Threshold percentage of common stock ownership upon preferred stock conversion |  |  |  |  |  | 9.99% |  |  |  | 9.99% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Maximum equity commitment amount under agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 15,000,000 |
Equity commitment agreement period |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 36 months |
Cash drawn from facility |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,000,000 |
Sale of stock, price per share | $ 5.86 |  | $ 2.12 | $ 2.26 | $ 2.76 |  | $ 2.26 |  |  |  |  |  | $ 1.83 |  |  |  |  |  |  |  |  | $ 1,000 | $ 1,000 | $ 1,000 | $ 3.70 |  |  |
Aggregate purchase price of preferred shares |  |  |  |  |  |  |  | 1,618,509 | 300,000 |  |  |  |  |  |  |  |  |  |  |  | 1,015,000 |  |  |  |  |  |  |
Issuance and sold of Common Stock | 3,071,672 |  | 1,667,051 | 1,825,079 | 2,260,869 |  |  |  |  |  |  |  | 14,300,000 | 848,961 | 1,182,451 | 15,511 | 8,656 | 225,189 | 1,250 |  |  |  | 46,000 | 9,900 | 675,000 | 1,015 |  |
Number of shares converted in common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,015 | 1,015 |  |  |  |  |  |  |
Preferred stock converted to common stock, shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 275,782 |  |  |  |  |  |  |  |
Aggregate purchase price on issuance of common stock to be received |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2,497,500 |  |  |
Proceeds from issuance of common stock, preferred stock and warrants, net | 60,000,000 |  | 3,500,000 | 4,100,000 | 6,200,000 | 62,821,592 | 3,332,467 |  |  | 213,580,607 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Unit sold, description |  |  | Each unit consisted of one share of common stock and a warrant to purchase | Each unit consisted of one share of common stock and a warrant to purchase | Each unit consisted of one share of common stock and a warrant to purchase |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Warrant to purchase share of Common Stock |  |  | 0.5 | 0.5 | 0.75 |  | 0.5 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock exercise price |  |  |  |  | $ 3.25 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise price of warrant |  |  |  |  |  |  |  |  |  |  | 1.83 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Conversion price | $ 5.86 | $ 1.83 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Cash from issuance of equity |  | 36,000,000 |  |  |  | 60,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Aggregate price on issuance or Sale of equity | $ 64,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Reverse stock split ratio |  |  |  |  |  |  |  |  |  |  |  | 0.1 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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