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v3.6.0.2

Consolidated Statement of Stockholders' Equity - USD ($) | Total | Common stock issued for cash at $5.86 | Common stock issued for cash at $18.95 | Preferred stock issued for cash at $1,000 per share | Common Stock Issued to Galloway | Common stock issued for cash at $5.90 per share | Novartis | Amgen | Preferred Stock | Preferred Stock Preferred stock issued for cash at $1,000 per share | Common Stock | Common Stock Common stock issued for cash at $5.86 | Common Stock Common stock issued for cash at $18.95 | Common Stock Common Stock Issued to Galloway | Common Stock Common stock issued for cash at $5.90 per share | Common Stock Novartis | Common Stock Amgen | Additional Paid In Capital | Additional Paid In Capital Common stock issued for cash at $5.86 | Additional Paid In Capital Common stock issued for cash at $18.95 | Additional Paid In Capital Preferred stock issued for cash at $1,000 per share | Additional Paid In Capital Common Stock Issued to Galloway | Additional Paid In Capital Common stock issued for cash at $5.90 per share | Additional Paid In Capital Novartis | Additional Paid In Capital Amgen | Accumulated Other Comprehensive Income (loss) | Accumulated Deficit | Noncontrolling Interest
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Beginning Balance, Amount at Sep. 30, 2013 | $ 25,734,789 |  |  |  |  |  |  |  | $ 10 |  | $ 124,859 |  |  |  |  |  |  | $ 193,514,766 |  |  |  |  |  |  |  |  | $ (166,140,969) | $ (1,763,877)
Beginning Balance, Shares at Sep. 30, 2013 |  |  |  |  |  |  |  |  | 9,900 |  | 32,489,444 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of warrants, Amount | 10,148,044 |  |  |  |  |  |  |  |  |  | $ 2,911 |  |  |  |  |  |  | 10,145,133 |  |  |  |  |  |  |  |  |  |
Exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | 2,911,919 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options, Amount | 2,730,000 |  |  |  |  |  |  |  |  |  | $ 455 |  |  |  |  |  |  | 2,729,545 |  |  |  |  |  |  |  |  |  |
Exercise of stock options, Shares |  |  |  |  |  |  |  |  |  |  | 454,863 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation | 5,696,173 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,696,173 |  |  |  |  |  |  |  |  |  |
Stock issuances |  | $ 14,060,112 | $ 112,581,559 | $ 46,000,000 | $ 500,000 |  |  |  |  | $ 46 |  | $ 3,072 | $ 6,325 | $ 132 |  |  |  |  | $ 14,057,040 | $ 112,575,234 | $ 45,999,954 | $ 499,868 |  |  |  |  |  |
Stock issuances, Shares |  |  |  |  |  |  |  |  |  | 46,000 |  | 3,071,672 | 6,325,000 | 131,579 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Settlements related to derivative liability | 5,956,079 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 5,956,079 |  |  |  |  |  |  |  |  |  |
Preferred stock converted to common stock, Amount |  |  |  |  |  |  |  |  | $ (38) |  | $ 9,272 |  |  |  |  |  |  | (9,234) |  |  |  |  |  |  |  |  |  |
Preferred stock converted to common stock, Shares |  |  |  |  |  |  |  |  | (37,600) |  | 9,272,459 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Deconsolidation of Calando Pharmaceuticals, Inc. | 1,303,911 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,303,911
Net loss | (58,725,412) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (58,630,190) | (95,222)
Ending Balance, Amount at Sep. 30, 2014 | 165,985,255 |  |  |  |  |  |  |  | $ 18 |  | $ 147,026 |  |  |  |  |  |  | 391,164,558 |  |  |  |  |  |  |  |  | (224,771,159) | (555,188)
Ending Balance, Shares at Sep. 30, 2014 |  |  |  |  |  |  |  |  | 18,300 |  | 54,656,936 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of warrants, Amount | 401,876 |  |  |  |  |  |  |  |  |  | $ 81 |  |  |  |  |  |  | 401,795 |  |  |  |  |  |  |  |  |  |
Exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | 79,828 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options, Amount | 101,870 |  |  |  |  |  |  |  |  |  | $ 29 |  |  |  |  |  |  | 101,841 |  |  |  |  |  |  |  |  |  |
Exercise of stock options, Shares |  |  |  |  |  |  |  |  |  |  | 28,758 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation | 10,232,897 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10,232,897 |  |  |  |  |  |  |  |  |  |
Exercise of exchange rights, Amount | 3,072 |  |  |  |  |  |  |  |  |  | $ 5 |  |  |  |  |  |  | 3,067 |  |  |  |  |  |  |  |  |  |
Exercise of exchange rights, Shares |  |  |  |  |  |  |  |  |  |  | 5,250 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Preferred stock converted to common stock, Amount |  |  |  |  |  |  |  |  | $ (2) |  | $ 1,316 |  |  |  |  |  |  | (1,314) |  |  |  |  |  |  |  |  |  |
Preferred stock converted to common stock, Shares |  |  |  |  |  |  |  |  | (2,648) |  | 1,316,215 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Common stock- Restricted Stock Units vesting, Amount | (26,029) |  |  |  |  |  |  |  |  |  | $ 136 |  |  |  |  |  |  | (26,165) |  |  |  |  |  |  |  |  |  |
Common stock- Restricted Stock Units vesting, Shares |  |  |  |  |  |  |  |  |  |  | 136,307 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issuances |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |  |  |  |  | $ 3,321 |  |  |  |  |  |  |  | $ 24,996,679 |  |  |  |
Stock issuances, Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 3,321,383 |  |  |  |  |  |  |  |  |  |  |  |
Foreign Currency Translation Adjustments | (136,425) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ (136,425) |  |
Net loss | (91,940,882) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (91,940,882) |
Ending Balance, Amount at Sep. 30, 2015 | 109,621,634 |  |  |  |  |  |  |  | $ 16 |  | $ 151,914 |  |  |  |  |  |  | 426,873,358 |  |  |  |  |  |  |  | (136,425) | (316,712,041) | (555,188)
Ending Balance, Shares at Sep. 30, 2015 |  |  |  |  |  |  |  |  | 15,652 |  | 59,544,677 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of warrants, Amount | 3,691,398 |  |  |  |  |  |  |  |  |  | $ 853 |  |  |  |  |  |  | 3,690,545 |  |  |  |  |  |  |  |  |  |
Exercise of warrants, Shares |  |  |  |  |  |  |  |  |  |  | 852,532 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Exercise of stock options, Amount | $ 133,869 |  |  |  |  |  |  |  |  |  | $ 37 |  |  |  |  |  |  | 133,832 |  |  |  |  |  |  |  |  |  |
Exercise of stock options, Shares | 37,187 |  |  |  |  |  |  |  |  |  | 37,187 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock-based compensation | $ 11,595,816 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 11,595,816 |  |  |  |  |  |  |  |  |  |
Stock issuances |  |  |  |  |  | $ 43,231,435 |  | $ 9,000,000 |  |  |  |  |  |  | $ 7,627 |  | $ 1,257 |  |  |  |  |  | $ 43,223,808 |  | $ 8,998,743 |  |  |
Stock issuances, Shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 7,627,119 |  | 1,256,983 |  |  |  |  |  |  |  |  |  |  |
Common stock- Restricted Stock Units vesting, Amount | (670,765) |  |  |  |  |  |  |  |  |  | $ 428 |  |  |  |  |  |  | (671,193) |  |  |  |  |  |  |  |  |  |
Common stock- Restricted Stock Units vesting, Shares |  |  |  |  |  |  |  |  |  |  | 428,187 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Foreign Currency Translation Adjustments | 143,874 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 143,874 |  |
Net loss | (81,723,002) |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | (81,723,002) |
Ending Balance, Amount at Sep. 30, 2016 | $ 95,024,259 |  |  |  |  |  |  |  | $ 16 |  | $ 162,116 |  |  |  |  |  |  | $ 493,844,909 |  |  |  |  |  |  |  | $ 7,449 | $ (398,435,043) | $ (555,188)
Ending Balance, Shares at Sep. 30, 2016 |  |  |  |  |  |  |  |  | 15,652 |  | 69,746,685 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

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