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Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Sep. 30, 2017 | Sep. 30, 2016 | Sep. 30, 2015
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net loss | $ (34,380,295) | $ (81,723,002) | $ (91,940,882)
(Gain) loss on disposal of fixed assets |  |  | (19,195)
Change in value of derivatives | (890,362) | 301,022 | (2,869,267)
Contingent consideration - fair value adjustments |  | (5,862,464) | 1,891,533
Noncash impairment expense |  | 2,050,817 |
Acquired in-process research and development |  |  | 10,142,786
Stock-based compensation | 7,891,595 | 11,595,816 | 10,232,897
Depreciation and amortization | 4,690,440 | 3,260,045 | 2,336,207
Amortization/(accretion) of note premiums | (43,519) | 231,902 | 1,110,524
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 7,203 | (75,000) |
Prepaid expenses and Other Current Assets | 2,814,509 | (1,020,734) | (3,485,421)
Deferred revenue | 157,981 | 5,000,000 |
Accounts payable | (3,509,995) | 2,554,802 | 2,497,804
Accrued expenses | (401,777) | (871,833) | 4,435,784
Other | (274,752) | 131,143 | (40,385)
NET CASH PROVIDED BY (USED IN) OPERATING ACTIVITIES | (23,938,972) | (64,427,486) | (65,707,615)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchases of property and equipment | (7,918,198) | (3,860,237) | (1,970,612)
Proceeds from sale of fixed assets |  |  | 500
Purchases of marketable securities | (44,974,736) |  |
Proceeds from sale of marketable securities | 4,248,716 | 17,308,000 | 26,090,950
Cash paid for acquisitions |  |  | (10,000,000)
NET CASH PROVIDED BY (USED IN) INVESTING ACTIVITIES | (48,644,218) | 13,447,763 | 14,120,838
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Principal payments on notes payable | (197,790) | (217,549) | (213,991)
Payments of taxes for net share settled restricted stock unit issuances | (438,838) | (634,187) |
Proceeds from the exercises of warrants and stock options | 272,818 | 3,752,120 | 504,512
Proceeds from the issuance of common stock | 12,419,119 | 52,231,433 |
NET CASH PROVIDED BY (USED IN) FINANCING ACTIVITIES | 12,055,309 | 55,131,817 | 290,521
NET INCREASE (DECREASE) IN CASH | (60,527,881) | 4,152,094 | (51,296,256)
CASH AT BEGINNING OF PERIOD | 85,366,448 | 81,214,354 | 132,510,610
CASH AT END OF PERIOD | 24,838,567 | 85,366,448 | 81,214,354
Supplementary disclosures: |  |  |
Interest Paid | (187,647) | (11,287) | (14,429)
Property and equipment purchased through tenant improvement allowance financing |  | (4,849,360) |
Property and Equipment expenditures included in accounts payable and accrued expenses |  | (4,801,930) |
Income Tax Credits Refunded | 3,635,016 | 1,365,288 |
Income Tax Paid | $ (2,400) | $ (2,400) | (2,400)
Novartis |  |  |
Supplementary disclosures: |  |  |
Common Stock issued to Novartis for asset acquisition |  |  | $ (25,000,000)

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- Definition The consolidated profit or loss for the period, net of income taxes, including the portion attributable to the noncontrolling interest. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4K -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591552-111686 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 45 -Paragraph 19 -URI http://asc.fasb.org/extlink&oid=96868048&loc=SL4569616-111683 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=84161450&loc=SL4573702-111684 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 55 -Paragraph 4J -URI http://asc.fasb.org/extlink&oid=84234705&loc=SL4591551-111686 Reference 5: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 810 -SubTopic 10 -Section 50 -Paragraph 1A -Subparagraph (a)(2) -URI http://asc.fasb.org/extlink&oid=84161450&loc=SL4573702-111684 + Details
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