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Collaboration and License Agreements - Janssen Pharmaceuticals, Inc - Additional Information (Detail)		3 Months Ended		6 Months Ended
	Oct. 03, 2018 USD ($) Target Obligation	Mar. 31, 2021 USD ($)	Mar. 31, 2020 USD ($)	Mar. 31, 2021 USD ($)	Mar. 31, 2020 USD ($)	Sep. 30, 2020 USD ($)
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the issuance of common stock					$ 250,479,000
Revenues		$ 32,811,000	$ 23,529,000	$ 54,113,000	52,983,000
Contract liabilities, current deferred revenue		144,879,000		144,879,000		$ 19,291,000
Collaboration and License agreements
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Initial transaction price	$ 252,700,000
JJDC | Common Stock Purchase Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Agreement date	Oct. 03, 2018
Proceeds from the issuance of common stock	$ 75,000,000.0
Janssen and JJDC | Collaboration and License agreements
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cash received as due under collaboration agreement	$ 175,000,000.0
Janssen | License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Agreement date	Oct. 03, 2018
Janssen | License Agreement | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development, regulatory and sales milestones payments	$ 1,600,000,000
Janssen | Research Collaboration and Option Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Agreement date	Oct. 03, 2018
Number of additional targets for development, regulatory and sales milestone payments | Target	3
Janssen | Collaboration Agreement | Maximum
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development, regulatory and sales milestones payments	$ 1,900,000,000
Janssen | JNJ-3989 (ARO-HBV) Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Milestone payment	$ 25,000,000.0	25,000,000.0		25,000,000.0
Number of distinct performance obligations | Obligation	1
Revenues		7,500,000	22,200,000	20,200,000	50,900,000
Contract assets		600,000		600,000
Contract liabilities, current deferred revenue		0		0
Janssen | ARO-JNJ1
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenues		100,000	$ 1,400,000	300,000	$ 2,100,000
Contract assets		300,000		300,000
Contract liabilities, current deferred revenue		$ 0		$ 0

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