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Collaboration and License Agreements - Horizon Therapeutics Ireland DAC - Additional Information (Detail) - Horizon Therapeutics Ireland DAC $ in Millions	Jun. 18, 2021 USD ($) Obligation	Oct. 07, 2020 Obligation Bundle	Jul. 31, 2021 USD ($)
ARO-XDH
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Agreement date	Jun. 18, 2021
Number of distinct performance obligations | Obligation	1
Initial transaction price	$ 40.0
ARO-XDH | Subsequent Event
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cash received as due under collaboration agreement			$ 40.0
License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Number of distinct bundle | Bundle		1
Number of distinct performance obligations | Obligation		1
Maximum | ARO-XDH
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development regulatory and sales milestones payments	$ 660.0

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