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Collaboration and License Agreements - Amgen, Inc. (Details) | Sep. 28, 2016 USD ($) agreement | Sep. 30, 2023 USD ($) | Dec. 31, 2022 USD ($) | Sep. 30, 2022 USD ($) | Jul. 31, 2020 USD ($) | Sep. 30, 2018 USD ($)
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Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Contract liabilities |  | $ 866,000 |  | $ 74,099,000 |  |
Amgen | Olpasiran Agreement |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Number of agreements | agreement | 2 |  |  |  |  |
Upfront payment | $ 35,000,000 |  |  |  |  |
Proceeds from the sale of future royalties | $ 21,500,000 |  |  |  |  |
Milestone payments |  | 55,000,000 | $ 25,000,000 |  | $ 20,000,000 | $ 10,000,000
Contract liabilities |  | 0 |  |  |  |
Contract assets |  | 0 |  |  |  |
Amgen | Olpasiran Agreement | Maximum |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Additional remaining development regulatory and sales milestones payments |  | $ 535,000,000 |  |  |  |

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