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Collaboration and License Agreements - Joint Venture and License Agreement with Visirna Therapeutics, Inc. (Details) - USD ($) $ in Thousands		3 Months Ended		6 Months Ended
	Apr. 25, 2022	Mar. 31, 2023	Mar. 31, 2022	Mar. 31, 2023	Mar. 31, 2022	Sep. 30, 2022
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the sale of future royalties				$ 250,000	$ 0
Revenue		$ 146,267	$ 151,805	208,813	$ 179,244
Deferred revenue		29,839		29,839		$ 74,099
Visirna Therapeutics, Inc. | Visirna License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Revenue				900
Contract assets		0		0
Deferred revenue		$ 0		$ 0
Visirna Therapeutics, Inc. | Visirna License Agreement | Variable Interest Entity, Primary Beneficiary
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Proceeds from the sale of future royalties	$ 60,000

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