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Insider Trading Arrangements | 3 Months Ended
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Sep. 30, 2025 shares
Trading Arrangements, by Individual |
Material Terms of Trading Arrangement | During the fiscal quarter ended September 30, 2025, the following directors and officers (as defined in Exchange Act Rule 16a-1(f)) adopted certain trading plans intended to satisfy Rule 10b5-1(c):
Name |  | Title |  | Adoption or Termination Date |  | Plan End Date |  | Shares Vesting and Subject to Sell-To-Cover (1) |  | Other Shares Being Sold (Subject to Certain Conditions)
Adeoye Olukotun |  | Board Member |  | 09/04/2025 |  | 12/24/2025 |  | n/a |  | 10,000
Christopher Anzalone |  | President and Chief Executive Officer |  | 09/19/2025 |  | 12/24/2026 |  | 50,000 |  | n/a
Daniel Apel |  | Chief Financial Officer |  | 09/16/2025 |  | 04/30/2026 |  | 25,000 |  | n/a
James Hamilton |  | Chief Medical Officer, Head of R&D |  | 09/03/2025 |  | 01/16/2026 |  | 72,500 |  | n/a
Mauro Ferrari |  | Board Member |  | 09/25/2025 |  | 12/31/2025 |  | n/a |  | 7,530
Patrick O'Brien |  | Chief Operating Officer & General Counsel |  | 09/03/2025 |  | 01/07/2026 |  | 77,500 |  | 20,000
Victoria Vakiener |  | Board Member |  | 09/03/2025 |  | 12/31/2025 |  | n/a |  | 10,040
William Waddill |  | Board Member |  | 09/03/2025 |  | 12/31/2025 |  | n/a |  | 8,367
(1) This column indicates the total number of shares vesting, but the 10b5-1 Plan provides for the sale of only those shares necessary to satisfy payment of applicable withholding taxes.
Non-Rule 10b5-1 Arrangement Adopted | false
Rule 10b5-1 Arrangement Terminated | false
Non-Rule 10b5-1 Arrangement Terminated | false
Adeoye Olukotun [Member] |
Trading Arrangements, by Individual |
Name | Adeoye Olukotun
Title | Board Member
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/04/2025
Expiration Date | 12/24/2025
Arrangement Duration | 111 days
Aggregate Available | 10,000
Christopher Anzalone [Member] |
Trading Arrangements, by Individual |
Name | Christopher Anzalone
Title | President and Chief Executive Officer
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/19/2025
Expiration Date | 12/24/2026
Arrangement Duration | 461 days
Aggregate Available | 50,000
Daniel Apel [Member] |
Trading Arrangements, by Individual |
Name | Daniel Apel
Title | Chief Financial Officer
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/16/2025
Expiration Date | 04/30/2026
Arrangement Duration | 226 days
Aggregate Available | 25,000
James Hamilton [Member] |
Trading Arrangements, by Individual |
Name | James Hamilton
Title | Chief Medical Officer, Head of R&D
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/03/2025
Expiration Date | 01/16/2026
Arrangement Duration | 135 days
Aggregate Available | 72,500
Mauro Ferrari [Member] |
Trading Arrangements, by Individual |
Name | Mauro Ferrari
Title | Board Member
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/25/2025
Expiration Date | 12/31/2025
Arrangement Duration | 97 days
Aggregate Available | 7,530
Patrick O'Brien [Member] |
Trading Arrangements, by Individual |
Name | Patrick O'Brien
Title | Chief Operating Officer & General Counsel
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/03/2025
Expiration Date | 01/07/2026
Arrangement Duration | 126 days
Victoria Vakiener [Member] |
Trading Arrangements, by Individual |
Name | Victoria Vakiener
Title | Board Member
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/03/2025
Expiration Date | 12/31/2025
Arrangement Duration | 119 days
Aggregate Available | 10,040
William Waddill [Member] |
Trading Arrangements, by Individual |
Name | William Waddill
Title | Board Member
Rule 10b5-1 Arrangement Adopted | true
Adoption Date | 09/03/2025
Expiration Date | 12/31/2025
Arrangement Duration | 119 days
Aggregate Available | 8,367
Patrick O'Brien, Shares Vesting And Subject to Sell-To-Cover [Member] | Patrick O'Brien [Member] |
Trading Arrangements, by Individual |
Aggregate Available | 77,500
Patrick O'Brien, Other Shares Being Sold [Member] | Patrick O'Brien [Member] |
Trading Arrangements, by Individual |
Aggregate Available | 20,000

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