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Organization and Significant Accounting Policies - Narrative (Details) - USD ($) $ in Thousands |  |  | 1 Months Ended | 3 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Feb. 07, 2025 | Nov. 25, 2024 | Feb. 10, 2025 | Dec. 31, 2024 | Dec. 31, 2023 | Sep. 30, 2024 | Sep. 30, 2023
Organization And Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Cash, cash equivalents and restricted cash |  |  |  | $ 53,889 | $ 58,215 | $ 102,685 | $ 110,891
Restricted cash |  |  |  | 2,100 |  |  |
Available-for-sale securities, at fair value |  |  |  | 499,046 |  | $ 578,276 |
Increase (decrease) in cash and investments |  |  |  | (128,000) |  |  |
Proceeds from the issuance of pre-funded warrants |  | $ 25,000 |  | 25,000 | $ 0 |  |
Development regulatory and sales milestones payments |  |  |  | $ 14,100,000 |  |  |
Sarepta | Sarepta Collaboration Agreement |  |  |  |  |  |  |
Organization And Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Equity investment |  | 325,000 |  |  |  |  |
Cash receivable under collaboration agreement |  | 500,000 |  |  |  |  |
Additional cash receivable under collaboration agreement |  | $ 250,000 |  |  |  |  |
Annual installments period |  | 5 years |  |  |  |  |
Enrollment related milestone payments |  | $ 300,000 |  |  |  |  |
Sarepta | Sarepta Collaboration Agreement | Subsequent Event |  |  |  |  |  |  |
Organization And Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Equity investment | $ 325,000 |  |  |  |  |  |
Cash receivable under collaboration agreement | 500,000 |  |  |  |  |  |
Additional cash receivable under collaboration agreement | $ 250,000 |  |  |  |  |  |
Annual installments period | 5 years |  |  |  |  |  |
Enrollment related milestone payments | $ 300,000 |  |  |  |  |  |
Future potential milestone payments | $ 10,000,000 |  |  |  |  |  |
GSK | GSK-HBV Agreement | Subsequent Event |  |  |  |  |  |  |
Organization And Significant Accounting Policies [Line Items] |  |  |  |  |  |  |
Development milestone payments |  |  | $ 2,500 |  |  |  |

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