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Collaboration and License Agreements - GlaxoSmithKline Intellectual Property (No. 3) Limited (“GSK”) (Details) - GSK - USD ($) |  | 1 Months Ended |  |  |
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Nov. 22, 2021 | Dec. 31, 2023 | Dec. 31, 2024 | Dec. 11, 2023 | Jun. 30, 2023
GSK-HSD License Agreement |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Initial transaction price | $ 120,000,000 |  |  |  |
Milestone payment receivable |  |  |  |  | $ 30,000,000
Milestone payment receivable upon achievement of phase two and first patient dosed in phase three | 100,000,000 |  |  |  |
GSK-HSD License Agreement | Maximum |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Commercial milestone payments at first commercial sale | 190,000,000 |  |  |  |
Sales-related milestone payments | $ 590,000,000 |  |  |  |
GSK-HBV Agreement |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Initial transaction price |  | $ 2,700,000 |  |  |
Milestone payment receivable |  |  | $ 2,500,000 |  |
Contract assets |  |  | 2,500,000 |  |
Contract liabilities |  |  | $ 0 |  |
GSK-HBV Agreement | Maximum |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |
Development and sales milestone payments |  |  |  | $ 830,000,000 |

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