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Organization and Significant Accounting Policies - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands |  |  | 3 Months Ended | 6 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | --- | ---
Feb. 24, 2025 | Feb. 07, 2025 | Mar. 31, 2025 | Mar. 31, 2025 | Sep. 30, 2024 | Mar. 31, 2024 | Sep. 30, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Cash, cash equivalents and restricted cash |  |  | $ 185,709 | $ 185,709 | $ 102,685 | $ 127,704 | $ 110,891
Restricted cash |  |  | 2,100 | 2,100 |  |  |
Available-for-sale securities |  |  | 911,700 | 911,700 | $ 578,276 |  |
Increase (decrease) in cash and investments |  |  |  | 416,400 |  |  |
Development regulatory and sales milestones payments |  |  | 13,300,000 | $ 13,300,000 |  |  |
Sarepta | Sarepta Collaboration Agreement |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Proceeds from sale of stock |  | $ 325,000 |  |  |  |  |
Shares of common stock issued (in shares) |  | 11,926,301 |  |  |  |  |
Common stock sold price (in dollars per share) |  | $ 27.25 |  |  |  |  |
Upfront payment | $ 500,000 |  |  |  |  |  |
Annual fees |  | $ 250,000 |  |  |  |  |
Annual installments period |  | 5 years |  |  |  |  |
Enrollment related milestone payments |  | $ 300,000 |  |  |  |  |
Future potential milestone payments |  | $ 10,000,000 |  |  |  |  |
GSK | GSK-HBV Agreement |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |
Development milestone payments |  |  | $ 2,500 |  |  |  |

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