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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating Activities |  |  |
Net (loss) income | $ (49,593) | $ (120,348) | $ 15,424
Adjustments to reconcile net (loss) income to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 29,661 | 29,381 | 6,306
Amortization of the fair market value inventory adjustment as a result of the Avedro Merger |  | 24,712 | 4,026
Amortization of right-of-use lease assets | 4,760 | 5,232 | 3,557
Amortization of debt issuance costs | 1,373 | 364 |
Amortization of debt discount |  | 5,610 |
Deferred income tax benefit | (1,029) | (12,176) | (66,306)
Loss on disposal of fixed assets | 7 | 367 | 430
Stock-based compensation | 30,146 | 46,477 | 36,393
Change in fair value of cash settled stock options |  | (3,172) | 3,088
Unrealized foreign currency losses (gains) | 2,313 | (1,202) | 194
Amortization of premium (discount) on short-term investments | 1,028 | 453 | (338)
Other liabilities | 2,465 | 4,538 | 5,352
Changes in operating assets and liabilities: |  |  |
Accounts receivable, net | 1,700 | 2,243 | (6,632)
Inventory | (7,703) | 1,962 | 52
Prepaid expenses and other current assets | (3,054) | (5,033) | (917)
Accounts payable and accrued liabilities | 12,448 | (2,683) | 779
Other assets | 186 | 287 | (1,777)
Net cash provided by (used in) operating activities | 24,708 | (22,988) | (369)
Investing activities |  |  |
Cash acquired due to acquisition |  |  | 49,652
Purchases of property and equipment | (47,785) | (6,935) | (4,724)
Purchases of short-term investments | (215,285) | (301,002) | (80,388)
Proceeds from sales and maturities of short-term investments | 206,916 | 104,697 | 80,494
Proceeds from disposal of property and equipment | 3 |  |
Investment in company-owned life insurance | (2,081) | (1,820) | (1,608)
Net cash (used in) provided by investing activities | (58,232) | (205,060) | 43,426
Financing activities |  |  |
Proceeds from convertible senior notes |  | 287,500 |
Payment of convertible senior notes transaction costs |  | (9,614) |
Purchase of capped calls related to issuance of convertible senior notes |  | (35,679) |
Proceeds from exercise of stock options | 26,124 | 20,196 | 15,064
Share purchases under Employee Stock Purchase Plan | 4,817 | 4,025 | 3,388
Payment of employee taxes related to vested restricted stock units | (3,690) | (3,886) | (5,601)
Payment of debt assumed in the Avedro Merger |  |  | (22,496)
Proceeds from tenant improvement allowance | 12,668 |  |
Principal paid on finance lease | (659) |  |
Net cash provided by (used in) financing activities | 39,260 | 262,542 | (9,645)
Effect of exchange rate changes on cash and cash equivalents | (1,774) | (88) | (252)
Net increase in cash, cash equivalents and restricted cash | 3,962 | 34,406 | 33,160
Cash, cash equivalents and restricted cash at beginning of period | 106,162 | 71,756 | 38,596
Cash, cash equivalents and restricted cash at end of period | 110,124 | 106,162 | 71,756
Supplemental schedule of noncash investing and financing activities |  |  |
Shares issued and Replacement Awards assumed in connection with Avedro Merger |  |  | 437,751
Debt assumed in the Avedro Merger |  |  | 22,496
Purchase of property and equipment included in accounts payable and accrued liabilities | 2,263 | 641 | 995
Supplemental disclosures of cash flow information |  |  |
Taxes paid, net of refunds | 272 | 484 | 171
Interest paid on convertible senior notes | 7,907 | 4,041 | $ 2
Other interest paid | $ 4,074 | $ 1,334 |

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- Definition The amount of debt that an Entity assumes in acquiring a business or in consideration for an asset received in a noncash (or part noncash) acquisition. Noncash is defined as transactions during a period that affect recognized assets or liabilities but that do not result in cash receipts or cash payments in the period. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or cash payments in the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=123431023&loc=d3e4304-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=123431023&loc=d3e4313-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=123431023&loc=d3e4332-108586 + Details
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- Definition Amount of amortization expense for right-of-use asset from operating lease. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 + Details
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- Definition The cash inflow during the period from additional borrowings in aggregate debt. Includes proceeds from short-term and long-term debt. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3255-108585 + Details
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