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  <xsd:element id="gkos_NumberOfAdjacentFacilitiesRented" name="NumberOfAdjacentFacilitiesRented" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_DomesticOfficeLeasesMember" name="DomesticOfficeLeasesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_ShareBasedCompensationAwardTrancheFourMember" name="ShareBasedCompensationAwardTrancheFourMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_EffectiveIncomeTaxRateReconciliationUncertainTaxPositionsAmount" name="EffectiveIncomeTaxRateReconciliationUncertainTaxPositionsAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_NumberOfPerformanceObligationsForMajorityOfContractsWithCustomers" name="NumberOfPerformanceObligationsForMajorityOfContractsWithCustomers" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_PeriodForPaymentOnInvoiceTerms" name="PeriodForPaymentOnInvoiceTerms" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_RevenueFromContractWithCustomerShippingAndHandlingCostPolicyTextBlock" name="RevenueFromContractWithCustomerShippingAndHandlingCostPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_NumberOfCertificatesOfDeposit" name="NumberOfCertificatesOfDeposit" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="gkos_PurchaseObligationDueAfterTwelveMonths" name="PurchaseObligationDueAfterTwelveMonths" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_NumberOfMonthsOfLeaseTermForAdjustmentsOfLettersOfCreditBalanceOutstandingToBegin" name="NumberOfMonthsOfLeaseTermForAdjustmentsOfLettersOfCreditBalanceOutstandingToBegin" nillable="true" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="gkos_FrequencyOfAdjustmentsOfLettersOfCreditBalanceOutstanding" name="FrequencyOfAdjustmentsOfLettersOfCreditBalanceOutstanding" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_AdjustmentPercentageOfLettersOfCreditBalanceOutstanding" name="AdjustmentPercentageOfLettersOfCreditBalanceOutstanding" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_MinimalAmountOfLettersOfCreditBalanceOutstandingAfterAdjustments" name="MinimalAmountOfLettersOfCreditBalanceOutstandingAfterAdjustments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_AlisoViejoCaliforniaFacilityMember" name="AlisoViejoCaliforniaFacilityMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_NumberOfPropertiesLeased" name="NumberOfPropertiesLeased" nillable="true" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="gkos_NumberOfBuildingsLeased" name="NumberOfBuildingsLeased" nillable="true" type="xbrli:decimalItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="gkos_NetOperatingLossCarryforwardPercentOfUtilizationForNoExpirationDate" name="NetOperatingLossCarryforwardPercentOfUtilizationForNoExpirationDate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="gkos_PaymentsForInvestmentInCompanyOwnedLifeInsurancePolicy" name="PaymentsForInvestmentInCompanyOwnedLifeInsurancePolicy" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_SoftwareCostsPolicyTextBlock" name="SoftwareCostsPolicyTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_LesseeOperatingLeaseOptionToExtendValue" name="LesseeOperatingLeaseOptionToExtendValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_LesseeOperatingLeasePeriodForLeaseTermination" name="LesseeOperatingLeasePeriodForLeaseTermination" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_LeaseRightOfUseAsset" name="LeaseRightOfUseAsset" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="gkos_FinanceAndOperatingLeaseLiability" name="FinanceAndOperatingLeaseLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_LesseeFinancingLeaseOptionToExtendValue" name="LesseeFinancingLeaseOptionToExtendValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_PatentLitigationMember" name="PatentLitigationMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_AvedroInc.Member" name="AvedroInc.Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_GlaucomaMember" name="GlaucomaMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_CornealHealthMember" name="CornealHealthMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_RepaymentsOfAcquiredDebt" name="RepaymentsOfAcquiredDebt" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationForAcquisitionRequisiteServicePeriodRecognitionValue" name="AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationForAcquisitionRequisiteServicePeriodRecognitionValue" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_LesseeOperatingAndFinanceLeaseLiabilityMaturityTableTextBlock" name="LesseeOperatingAndFinanceLeaseLiabilityMaturityTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_ScheduleOfOperatingAndFinanceLeaseAssetsAndLiabilitiesTableTextBlock" name="ScheduleOfOperatingAndFinanceLeaseAssetsAndLiabilitiesTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_LesseeOperatingAndFinanceLeaseWeightedAverageLeaseTermAndDiscountRateTableTextBlock" name="LesseeOperatingAndFinanceLeaseWeightedAverageLeaseTermAndDiscountRateTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_OperatingAndFinanceLeaseSupplementalCashFlowTableTextBlock" name="OperatingAndFinanceLeaseSupplementalCashFlowTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_LeaseDisclosureTextBlock" name="LeaseDisclosureTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_NumberOfBusinessActivities" name="NumberOfBusinessActivities" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_AccruedLiabilityForCashSettledOptionsCurrentLiabilities" name="AccruedLiabilityForCashSettledOptionsCurrentLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_RestrictedCashPledgedForOfficeLeaseAgreement" name="RestrictedCashPledgedForOfficeLeaseAgreement" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="gkos_RestrictedCashPledgedForLetterOfCredit" name="RestrictedCashPledgedForLetterOfCredit" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="gkos_BurlingtonMassachusettsFacilityMember" name="BurlingtonMassachusettsFacilityMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_WalthamMassachusettsFacilityMember" name="WalthamMassachusettsFacilityMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_CashSettledStockOptionMember" name="CashSettledStockOptionMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_BusinessCombinationConsiderationTransferredStockIssuedForReplacementAwardsAttributableToPreCombinationServices" name="BusinessCombinationConsiderationTransferredStockIssuedForReplacementAwardsAttributableToPreCombinationServices" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionReplacementAwardsGrantsInPeriodGross" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionReplacementAwardsGrantsInPeriodGross" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionReplacementAwardsGrantsInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionReplacementAwardsGrantsInPeriodWeightedAverageExercisePrice" nillable="true" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_ShareBasedCompensationAwardTimeVestingMember" name="ShareBasedCompensationAwardTimeVestingMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_BusinessCombinationConsiderationTransferredStockIssuedForReplacementAwardsAttributableToPostCombinationServices" name="BusinessCombinationConsiderationTransferredStockIssuedForReplacementAwardsAttributableToPostCombinationServices" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_AccountingStandardUpdatesImplementationIncomeTaxExpenseBenefit" name="AccountingStandardUpdatesImplementationIncomeTaxExpenseBenefit" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_DeferredTaxAssetsTaxDeferredExpenseLeaseLiability" name="DeferredTaxAssetsTaxDeferredExpenseLeaseLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="gkos_DeferredTaxLiabilitiesDeferredExpenseLeaseAssets" name="DeferredTaxLiabilitiesDeferredExpenseLeaseAssets" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_TaxCreditCarryforwardNotSubjectToExpirationAmount" name="TaxCreditCarryforwardNotSubjectToExpirationAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="gkos_TaxCreditCarryForwardSubjectToExpirationAmount" name="TaxCreditCarryForwardSubjectToExpirationAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" />
  <xsd:element id="gkos_ChangeInDeferredIncomeTaxExpenseBenefit" name="ChangeInDeferredIncomeTaxExpenseBenefit" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_NoncashOrPartNoncashAcquisitionEquityIssuedAndAssumed" name="NoncashOrPartNoncashAcquisitionEquityIssuedAndAssumed" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_StockOptionPlanExpenses" name="StockOptionPlanExpenses" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_IncrementalCommonSharesAttributableToUnvestedRestrictedStockUnits" name="IncrementalCommonSharesAttributableToUnvestedRestrictedStockUnits" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_NumberOfVotesPerCommonShare" name="NumberOfVotesPerCommonShare" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" />
  <xsd:element id="gkos_PaymentForCappedCallTransactions" name="PaymentForCappedCallTransactions" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_TwoPointSevenFivePercentConvertibleSeniorNotesDue2027Member" name="TwoPointSevenFivePercentConvertibleSeniorNotesDue2027Member" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_NetProceedsFromIssuanceOfConvertibleDebt" name="NetProceedsFromIssuanceOfConvertibleDebt" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_ScheduleOfInterestExpenseOnConvertibleNotesTableTextBlock" name="ScheduleOfInterestExpenseOnConvertibleNotesTableTextBlock" nillable="true" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_DebtInstrumentNumberOfBusinessDays" name="DebtInstrumentNumberOfBusinessDays" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_DebtInstrumentMeasurementPeriod" name="DebtInstrumentMeasurementPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_PercentageOfProductOfSalePriceAndConversionRate" name="PercentageOfProductOfSalePriceAndConversionRate" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_DebtInstrumentPrincipalAmountDenominationForConversionIntoCommonStock" name="DebtInstrumentPrincipalAmountDenominationForConversionIntoCommonStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_PercentageOfPrincipalAmountOfConvertibleNotesToBeRepurchased" name="PercentageOfPrincipalAmountOfConvertibleNotesToBeRepurchased" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_CappedCallTransactionsMember" name="CappedCallTransactionsMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_PercentageOfPremiumOnSharePrice" name="PercentageOfPremiumOnSharePrice" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_AdjustmentsToAdditionalPaidInCapitalCappedCallTransactions" name="AdjustmentsToAdditionalPaidInCapitalCappedCallTransactions" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_AmortizationOfDiscountOnShortTermInvestments" name="AmortizationOfDiscountOnShortTermInvestments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_ConvertibleDebtTransactionCostsAmount" name="ConvertibleDebtTransactionCostsAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_ConvertibleDebtTaxesAmount" name="ConvertibleDebtTaxesAmount" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_SecuritiesHeldForDeferredCompensationPlansMember" name="SecuritiesHeldForDeferredCompensationPlansMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_ConvertibleLongTermNotesPayableLiability" name="ConvertibleLongTermNotesPayableLiability" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_InterestPaidNetConvertibleSeniorNotes" name="InterestPaidNetConvertibleSeniorNotes" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_MunicipalBondsSecuritiesMember" name="MunicipalBondsSecuritiesMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_GoodwillAbstract" name="GoodwillAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_DeferredTaxLiabilitiesConvertibleNotes" name="DeferredTaxLiabilitiesConvertibleNotes" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_AllocatedShareBasedCompensationExpenseFairValueAdjustment" name="AllocatedShareBasedCompensationExpenseFairValueAdjustment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_AmortizationOfFairMarketValueOfInventoryAdjustmentFromMerger" name="AmortizationOfFairMarketValueOfInventoryAdjustmentFromMerger" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_IncomeTaxReconciliationNetOperatingLossCarryback" name="IncomeTaxReconciliationNetOperatingLossCarryback" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" />
  <xsd:element id="gkos_DeferredFinanceCostsNoncurrentGrossEquityPortion" name="DeferredFinanceCostsNoncurrentGrossEquityPortion" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" />
  <xsd:element id="gkos_AmortizationPeriodOfDebtIssuanceCosts" name="AmortizationPeriodOfDebtIssuanceCosts" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element id="gkos_ProceedsFromTenantAllowance" name="ProceedsFromTenantAllowance" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_IncreaseDecreaseInOthersAccruedLiabilities" name="IncreaseDecreaseInOthersAccruedLiabilities" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" />
  <xsd:element id="gkos_UseOfEstimatesAbstract" name="UseOfEstimatesAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_AttillapsLicenseAgreementMember" name="AttillapsLicenseAgreementMember" nillable="true" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" />
  <xsd:element id="gkos_RoyaltyFeePercentage" name="RoyaltyFeePercentage" nillable="true" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" />
  <xsd:element name="AmortizationOfFinancingCost" id="gkos_AmortizationOfFinancingCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="DebtInterestExpenseAndAmortizationOfFinancingCostsAndDebtDiscounts" id="gkos_DebtInterestExpenseAndAmortizationOfFinancingCostsAndDebtDiscounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionAdjustmentToCertainPriorYearGrants" id="gkos_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionAdjustmentToCertainPriorYearGrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionAdjustmentsToCertainPriorYearGrantsWeightedAverageExercisePrice" id="gkos_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionAdjustmentsToCertainPriorYearGrantsWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IntratusLicenseAmendmentMember" id="gkos_IntratusLicenseAmendmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
</xsd:schema>
