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Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares
shares in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Anti-dilutive securities      
Anti-dilutive securities excluded from computation of earnings per share 8,827 4,940 4,007
Stock options      
Anti-dilutive securities      
Anti-dilutive securities excluded from computation of earnings per share 2,951 4,399 3,616
Restricted Stock Units (RSUs) [Member]      
Anti-dilutive securities      
Anti-dilutive securities excluded from computation of earnings per share 740 526 365
ESPP      
Anti-dilutive securities      
Anti-dilutive securities excluded from computation of earnings per share 11 15 26
Convertible senior note      
Anti-dilutive securities      
Anti-dilutive securities excluded from computation of earnings per share 5,125