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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
CONSOLIDATED STATEMENTS OF OPERATIONS      
Net sales $ 294,011 $ 224,959 $ 236,984
Cost of sales 66,627 91,719 38,588
Gross profit 227,384 133,240 198,396
Operating expenses:      
Selling, general and administrative 179,257 171,401 176,635
Research and development 100,999 85,392 68,308
In-process research and development 10,000   3,745
Litigation-related settlement (30,000)    
Total operating expenses 260,256 256,793 248,688
Loss from operations (32,872) (123,553) (50,292)
Non-operating (expense) income:      
Interest income 1,288 2,379 3,169
Interest expense (13,372) (14,115) (2,565)
Other (expense) income, net (4,311) 2,975 (348)
Total non-operating (expense) income (16,395) (8,761) 256
Loss before taxes (49,267) (132,314) (50,036)
Income tax provision (benefit) 326 (11,966) (65,460)
Net (loss) income $ (49,593) $ (120,348) $ 15,424
Basic net (loss) income per share (in dollar per share) $ (1.07) $ (2.70) $ 0.41
Diluted net (loss) income per share (in dollar per share) $ (1.07) $ (2.70) $ 0.37
Weighted average shares used to compute basic net (loss) income per share 46,423 44,497 37,355
Weighted average shares used to compute diluted net (loss) income per share 46,423 44,497 41,145