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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Operating Activities    
Net loss $ (97,882) $ (67,735)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation 6,455 4,710
Amortization of intangible assets 18,684 18,684
Noncash lease expense 3,218 3,378
Amortization of debt issuance costs 1,030 1,030
Deferred income tax benefit (15) (17)
Gain on disposal of fixed assets 881 29
Stock-based compensation 30,541 26,873
Unrealized foreign currency losses 991 4,219
Amortization of premium on short-term investments (1,041) 601
Other liabilities 2,231  
Acquired in-process R&D acquired through the issuance of common stock 3,000  
Changes in operating assets and liabilities:    
Accounts receivable, net (3,535) (3,121)
Inventory (2,903) (11,881)
Prepaid expenses and other current assets (2,355) (3,355)
Accounts payable and accrued liabilities (6,149) (1,847)
Other assets (244) (515)
Net cash used in operating activities (47,093) (28,947)
Investing activities    
Purchases of short-term investments (193,538) (47,256)
Proceeds from sales and maturities of short-term investments 238,735 97,494
Purchases of property and equipment (16,034) (22,044)
Proceeds from disposal of property and equipment   96
Investment in company-owned life insurance (2,147) (166)
Net cash provided by investing activities 27,016 28,124
Financing activities    
Proceeds from exercise of stock options 6,624 2,871
Proceeds from share purchases under Employee Stock Purchase Plan 6,278 5,630
Payment of employee taxes related to vested restricted stock units (4,646) (2,399)
Principal paid on finance lease (517) (380)
Net cash provided by financing activities 7,739 5,722
Effect of exchange rate changes on cash and cash equivalents 520 (1,927)
Net (decrease) increase in cash, cash equivalents and restricted cash (11,818) 2,972
Cash, cash equivalents and restricted cash at beginning of period 126,603 110,124
Cash, cash equivalents and restricted cash at end of period 114,785 113,096
Supplemental disclosures of cash flow information    
Taxes paid, net of refunds 1,218 372
Interest paid on convertible senior notes 3,953 3,953
Other interest paid 3,237 3,350
Supplemental schedule of noncash investing and financing activities    
Purchases of property and equipment included in accounts payable and accrued liabilities $ 3,201 $ 3,258