<SEC-DOCUMENT>0001415889-25-008254.txt : 20250317
<SEC-HEADER>0001415889-25-008254.hdr.sgml : 20250317
<ACCEPTANCE-DATETIME>20250317192951
ACCESSION NUMBER:		0001415889-25-008254
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20250313
FILED AS OF DATE:		20250317
DATE AS OF CHANGE:		20250317

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Gilliam Joseph E
		CENTRAL INDEX KEY:			0001705850
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-37463
		FILM NUMBER:		25746076

	MAIL ADDRESS:	
		STREET 1:		C/O GLAUKOS CORPORATION
		STREET 2:		229 AVENIDA FABRICANTE
		CITY:			SAN CLEMENTE
		STATE:			CA
		ZIP:			92677

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GLAUKOS Corp
		CENTRAL INDEX KEY:			0001192448
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		1 GLAUKOS WAY
		CITY:			ALISO VIEJO
		STATE:			CA
		ZIP:			92656
		BUSINESS PHONE:		949-367-9600

	MAIL ADDRESS:	
		STREET 1:		1 GLAUKOS WAY
		CITY:			ALISO VIEJO
		STATE:			CA
		ZIP:			92656

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	GLAUKOS CORP
		DATE OF NAME CHANGE:	20020925
</SEC-HEADER>
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<TYPE>4
<SEQUENCE>1
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    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2025-03-13</periodOfReport>

    <issuer>
        <issuerCik>0001192448</issuerCik>
        <issuerName>GLAUKOS Corp</issuerName>
        <issuerTradingSymbol>GKOS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001705850</rptOwnerCik>
            <rptOwnerName>Gilliam Joseph E</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O GLAUKOS CORPORATION</rptOwnerStreet1>
            <rptOwnerStreet2>ONE GLAUKOS WAY</rptOwnerStreet2>
            <rptOwnerCity>ALISO VIEJO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92656</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>PRESIDENT &amp; COO</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

    <nonDerivativeTable>
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                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
                <value>2025-03-13</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>3888</value>
                    <footnoteId id="F1"/>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
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                <sharesOwnedFollowingTransaction>
                    <value>105093</value>
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        <nonDerivativeTransaction>
            <securityTitle>
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                    <footnoteId id="F3"/>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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            <transactionDate>
                <value>2025-03-13</value>
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                <transactionCode>A</transactionCode>
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                <transactionAcquiredDisposedCode>
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                    <footnoteId id="F6"/>
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                <directOrIndirectOwnership>
                    <value>D</value>
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                </natureOfOwnership>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <transactionDate>
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            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>F</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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                    <footnoteId id="F7"/>
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                <transactionPricePerShare>
                    <value>102.19</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
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                    <footnoteId id="F8"/>
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                    <value>D</value>
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                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>55.18</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2025-03-13</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>13271</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <footnoteId id="F9"/>
            </exerciseDate>
            <expirationDate>
                <value>2032-03-24</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>13271</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>35713</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
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                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value></value>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeTransaction>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares of common stock underlying a portion of an award of restricted stock units previously granted by the Issuer on March 18, 2021, the vesting of which was subject to the Issuer's achievement of certain pre-determined operational targets over a multi-year performance period. The Compensation, Nominating &amp;amp; Governance Committee of the Issuer's Board of Directors (&quot;Compensation Committee&quot;) determined on March 13, 2025 that one of the operational targets had been achieved. The number of shares reported herein consists of the portion of the award that was deemed earned based upon the achievement of the operational target. 50% of the number of shares of common stock reported hereinwill vest and be delivered in May 2025 and the remaining 50% will vest and be delivered in February 2026.</footnote>
        <footnote id="F2">Includes 78,363 restricted stock units that have not yet vested or been delivered to the Reporting Person.</footnote>
        <footnote id="F3">Represents shares of common stock underlying a portion of an award of restricted stock units previously granted by the Issuer on March 14, 2024, the earning and vesting of which was subject to the Issuer's achievement of certain pre-determined operational targets over a multi-year performance period. The Compensation Committee determined on March 13, 2025 that one of the operational targets had been achieved. The number of shares reported herein consists of the portion of the award that was deemed earned based upon the achievement of the operational target. 100% of the number of shares of common stock reported herein were vested and delivered on March 13, 2025.</footnote>
        <footnote id="F4">Includes 84,192 restricted stock units that have not yet vested or been delivered to the Reporting Person.</footnote>
        <footnote id="F5">Granted by the Issuer in the form of restricted stock units which vest over a four-year period, with 25% to vest on each anniversary of the grant date</footnote>
        <footnote id="F6">Includes 96,479 restricted stock units that have not yet vested or been delivered to the Reporting Person.</footnote>
        <footnote id="F7">Consists of shares withheld by the Issuer with respect to tax withholding obligations of the Reporting Person upon vesting and delivery of shares of common stock underlying restricted stock units previously granted by the Issuer on March 14, 2024.</footnote>
        <footnote id="F8">Includes 94,294 restricted stock units that have not yet vested or been delivered to the Reporting Person.</footnote>
        <footnote id="F9">Represents a portion of an option to purchase shares of common stock previously granted by the Issuer on March 24, 2022, the vesting of which was subject to the Issuer's achievement of certain pre-determined operational targets over a multi-year performance period. The Compensation Committee determined on March 13, 2025 that certain of the operational targets had been achieved. The number of shares of common stock subject to the stock option as reported herein consists of the portion of the award that was earned based upon the achievement of the operational targets.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>Diana Scherer, Attorney-in-Fact</signatureName>
        <signatureDate>2025-03-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
