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Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |  |
Net loss | $ (100,077) | $ (89,217) | $ (50,274)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,800 | 1,405 | 1,232
Stock-based compensation expense | 10,729 | 5,434 | 1,185
Change in fair value of redeemable convertible preferred stock warrant |  | 179 | (12)
Change in fair value of redeemable convertible preferred stock tranche liabilities |  |  | (3,185)
Loss on disposal of assets | 97 | 34 | 1
Asset impairment charges | 0 | 267 | 0
Amortization of operating right-of-use assets | 1,657 |  |
Net amortization of premiums on investments | 1,406 |  |
Changes in operating assets and liabilities: |  |  |
Prepaid expenses and other current assets | (7,369) | (58) | (1,070)
Other assets | (3,539) | (75) | 120
Operating lease liabilities | (12,856) |  |
Accounts payable | (12,470) | 26,102 | 868
Accrued compensation | 3,170 | (130) | (775)
Accrued manufacturing expenses | (8,572) | 7,235 | 3,970
Accrued expenses | 4,631 | 2,207 | 718
Deferred rent and other long-term liabilities |  | (11) | 77
Net cash used in operating activities | (121,393) | (46,628) | (47,145)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (6,555) | (1,155) | (1,195)
Purchases of investments | (336,341) |  |
Maturities of investments | 100,500 |  |
Sales of investments | 30,062 |  |
Proceeds from sales of property and equipment | 26 | 50 |
Net cash used in investing activities | (212,308) | (1,105) | (1,195)
Cash flows from financing activities: |  |  |
Payments of capital lease obligations |  | (61) | (278)
Proceeds from initial public offering, net of underwriters' commissions and discounts |  | 267,375 |
Payment of issuance costs for initial public offering |  | (3,368) |
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs |  | 109,879 | 42,500
Proceeds from exercise of common stock options | 3,012 | 635 | 322
Proceeds from issuance of common stock under ATM Sales Program, net of issuance costs | 13,896 |  |
Proceeds from issuance of common stock related to early exercised stock options |  | 36 | 120
Proceeds from issuance of common stock under the Employee Stock Purchase Plan | 888 | 374 |
Payments of deferred offering costs |  |  | (1,097)
Net cash provided by financing activities | 17,796 | 374,870 | 41,567
Effect of exchange rate changes on cash and cash equivalents | (439) | 87 | (341)
Net (decrease) increase in cash, cash equivalents and restricted cash | (316,344) | 327,224 | (7,114)
Cash, cash equivalents and restricted cash, beginning of period | 386,200 | 58,976 | 66,090
Cash, cash equivalents and restricted cash, end of period | 69,856 | 386,200 | 58,976
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 7 | 7 | 40
Supplemental disclosures of non-cash investing and financing activities: |  |  |
Purchases of property and equipment recorded in accounts payable and accrued expenses | 766 | 494 | 21
Conversion of convertible preferred stock into common stock |  | 270,190 |
Stock issued for payment of accounts payable | $ 10,001 |  |
Deferred offering costs included in accounts payable and accrued expenses |  | $ 134 | $ 33

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