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Funding Arrangement - Additional Information (Details) - USD ($) | 1 Months Ended | 12 Months Ended |  |  |
--- | --- | --- | --- | --- | ---
Apr. 30, 2021 | Jul. 31, 2019 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | Jan. 31, 2022 | Aug. 04, 2021 | Jul. 31, 2020
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Grant income |  |  | $ 1,585,000 | $ 2,478,000 | $ 237,000 |  |  |
Cost Reimbursement Sub-Award Agreement |  |  |  |  |  |  |  |
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Funding period of award to develop universal vaccine to prevent infections caused by Group A Strep bacteria |  | 4 years |  |  |  |  |  |
Potential funding amount of award to develop vaccine to prevent shingella infections | $ 500,000 |  |  |  |  |  |  |
Grant income |  |  | 1,600,000 | 2,500,000 | $ 200,000 |  |  |
Cost Reimbursement Sub-Award Agreement | Maximum |  |  |  |  |  |  |  |
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Initial funding committed by award |  | $ 1,600,000 |  |  |  |  |  |
Total funding committed by award, available upon achievement of development milestones |  | $ 15,100,000 |  |  |  |  |  |
Potential funding period of award to develop vaccine to prevent shingella infections | 5 years |  |  |  |  |  |  |
CARB-X Agreement |  |  |  |  |  |  |  |
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Additional funding committed by award |  |  |  |  |  |  | $ 3,200,000 |
Grant receivable on unreimbursed, eligible costs incurred |  |  | $ 1,200,000 | $ 300,000 |  |  |  |
CARB-X Agreement | Subsequent Event |  |  |  |  |  |  |  |
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Potential funding committed by award |  |  |  |  |  | $ 13,900,000 |  |
CARB-X Agreement | Maximum |  |  |  |  |  |  |  |
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Initial funding committed by award |  |  |  |  |  |  |  | $ 2,700,000
Additional funding committed by award |  |  |  |  |  |  | 3,200,000 |
Potential funding committed by award |  |  |  |  |  |  | $ 29,700,000 |
CARB-X Agreement | Minimum |  |  |  |  |  |  |  |
Funding Arrangement [Line Items] |  |  |  |  |  |  |  |
Initial funding committed by award |  |  |  |  |  |  |  | $ 1,600,000

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