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Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Income Tax Disclosure [Abstract]

Reconciliation of Effective Tax Rate

A reconciliation of our effective tax rate to the statutory U.S. federal rate is as follows:

		Year Ended December 31,
		2021				2020(1)				2019(1)
Statutory rate			21.0	%			21.0	%			21.0	%
Stock-based compensation			2.2	%			0.8	%			(0.4	)%
Credits			1.1	%			0.6	%			(0.5	)%
Change in fair value of tranche liability			0.0	%			0.0	%			1.3	%
Change in valuation allowance			(23.0	)%			(22.1	)%			(21.8	)%
Section 162(m) limitation			(1.1	)%			(0.1	)%			0.0	%
Other			(0.2	)%			(0.2	)%			0.4	%
Total			0.0	%			0.0	%			0.0	%

(1)The 2019 and 2020 effective tax rate reconciliations have been updated to conform to the 2021 presentation.

Components of Deferred Tax Assets

The following table presents significant components of our deferred tax assets as of December 31, 2021 and 2020:

		As of December 31,
		2021				2020
		(in thousands)
Deferred tax assets:
Net operating losses			85,574				52,330
Fixed assets			1,700				528
Accruals & reserves			4,131				2,786
Credits			2,865				1,222
Section 59(e) capitalized expenses			2,984				3,381
Accrued manufacturing expenses			1,006				3,374
Lease liability			6,674				—
Total deferred tax assets			104,934				63,621
Deferred tax liabilities:
ROU asset			(8,349	)			—
Total deferred tax liabilities			(8,349	)			—
Net deferred tax asset			96,585				63,621
Valuation allowance			(96,585	)			(63,621	)
Net deferred taxes		$	—			$	—

Reconciliation of Unrecognized Tax Benefit

A reconciliation of the beginning and ending unrecognized tax benefit amount is as follows:

		December 31,
		2021				2020				2019
		(in thousands)
Balance at the beginning of the year		$	393			$	271			$	408
Additions based on tax positions related to current year			461				287				217
Adjustments based on tax positions related to prior years			70				(165	)			(354	)
Balance at end of year		$	924			$	393			$	271

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Tabular disclosure of the components of net deferred tax asset or liability recognized in an entity's statement of financial position, including the following: the total of all deferred tax liabilities, the total of all deferred tax assets, the total valuation allowance recognized for deferred tax assets.

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Tabular disclosure of the reconciliation using percentage or dollar amounts of the reported amount of income tax expense attributable to continuing operations for the year to the amount of income tax expense that would result from applying domestic federal statutory tax rates to pretax income from continuing operations.

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Tabular disclosure for tax positions taken in the tax returns filed or to be filed for which it is more likely than not that the tax position will not be sustained upon examination by taxing authorities and other income tax contingencies. Includes, but is not limited to, interest and penalties, reconciliation of unrecognized tax benefits, unrecognized tax benefits that would affect the effective tax rate, tax years that remain subject to examination by tax jurisdictions, and information about positions for which it is reasonably possible that amounts unrecognized will significantly change within 12 months.

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