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Equity Incentive Plans - Summary of Estimated Fair Value of Employee Stock Options (Details)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Fair Value Assumptions
Expected volatility, Minimum	81.00%	81.20%	78.40%
Expected volatility, Maximum	84.10%	94.10%	80.40%
Expected dividend yield	0.00%	0.00%	0.00%
Risk-free interest rate, Minimum	0.50%	0.30%	1.60%
Risk-free interest rate, Maximum	1.30%	1.40%	2.40%
Minimum
Fair Value Assumptions
Expected term (in years)	5 years 3 months 18 days	5 years 7 months 6 days	5 years 10 months 24 days
Maximum
Fair Value Assumptions
Expected term (in years)	5 years 6 months	6 years 1 month 6 days	6 years 1 month 6 days

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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- Definition

The estimated measure of the maximum percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The estimated measure of the minimum percentage by which a share price is expected to fluctuate during a period. Volatility also may be defined as a probability-weighted measure of the dispersion of returns about the mean. The volatility of a share price is the standard deviation of the continuously compounded rates of return on the share over a specified period. That is the same as the standard deviation of the differences in the natural logarithms of the stock prices plus dividends, if any, over the period.

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The maximum risk-free interest rate assumption that is used in valuing an option on its own shares.

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The minimum risk-free interest rate assumption that is used in valuing an option on its own shares.

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Expected term of award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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