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Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |  |
Net loss | $ (223,485) | $ (100,077) | $ (89,217)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 2,577 | 1,800 | 1,405
Stock-based compensation expense | 23,650 | 10,729 | 5,434
Non-cash payments for acquired manufacturing rights | 7,995 | 0 | 0
Change in fair value of redeemable convertible preferred stock warrant | 0 | 0 | 179
Loss on disposal of assets | 44 | 97 | 34
Asset impairment charges | 213 | 0 | 267
Amortization of operating right-of-use assets | 6,619 | 1,657 | 0
Net amortization of premiums on investments | (947) | 1,406 | 0
Changes in operating assets and liabilities: |  |  |
Prepaid expenses and other current assets | 433 | (7,369) | (58)
Other assets | (465) | (3,539) | (75)
Operating lease liabilities | 1,151 | (12,856) | 0
Accounts payable | 2,896 | (12,470) | 26,102
Accrued compensation | (2,275) | 3,170 | (130)
Accrued manufacturing expenses | 3,826 | (8,572) | 7,235
Accrued expenses | 7,171 | 4,631 | 2,207
Deferred rent and other long-term liabilities | 0 | 0 | (11)
Net cash used in operating activities | (170,597) | (121,393) | (46,628)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (5,848) | (6,555) | (1,155)
Purchases of investments | (102,745) | (336,341) | 0
Maturities of investments | 168,691 | 100,500 | 0
Sales of investments | 14,480 | 30,062 | 0
Proceeds from sales of property and equipment | 7 | 26 | 50
Net cash provided by (used in) investing activities | 74,585 | (212,308) | (1,105)
Cash flows from financing activities: |  |  |
Payments of capital lease obligations | 0 | 0 | (61)
Proceeds from initial public offering, net of issuance costs | 0 | 0 | 264,007
Proceeds from issuance of common stock and pre-funded warrants from follow-on offerings, net of issuance costs | 759,181 | 0 | 0
Proceeds from issuance of common stock under ATM Sales Program, net of issuance costs | 97,299 | 13,896 | 0
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | 0 | 0 | 109,879
Proceeds from exercise of common stock options | 4,895 | 3,012 | 635
Proceeds from issuance of common stock related to early exercised stock options | 0 | 0 | 36
Proceeds from issuance of common stock under the Employee Stock Purchase Plan | 1,033 | 888 | 374
Release of restricted stock units | (861) | 0 | 0
Net cash provided by financing activities | 861,547 | 17,796 | 374,870
Effect of exchange rate changes on cash and cash equivalents | 137 | (439) | 87
Net increase (decrease) in cash, cash equivalents and restricted cash | 765,672 | (316,344) | 327,224
Cash, cash equivalents and restricted cash, beginning of period | 69,856 | 386,200 | 58,976
Cash, cash equivalents and restricted cash, end of period | 835,528 | 69,856 | 386,200
Supplemental disclosure of cash flow information: |  |  |
Cash paid for interest | 2 | 7 | 7
Supplemental disclosures of non-cash investing and financing activities: |  |  |
Purchases of property and equipment recorded in accounts payable and accrued expenses | 110 | 766 | 494
Issuance of common stock for acquired manufacturing rights | 7,995 | 0 | 0
Conversion of convertible preferred stock into common stock | 0 | 0 | 270,190
Stock issued for payment of accounts payable | 0 | 10,000 | 0
Deferred offering costs included in accounts payable and accrued expenses | $ 0 | $ 0 | $ 134

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