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v3.23.3

Condensed Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2023 | Sep. 30, 2022
Cash flows from operating activities: |  |
Net loss | $ (221,465) | $ (145,435)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,268 | 1,875
Stock-based compensation expense | 35,412 | 16,641
Amortization of operating lease right-of-use assets | 4,955 | 5,021
Net amortization (accretion) of premiums (discounts) on investments | (32,406) | 228
Loss on disposal of fixed assets | 0 | 44
Asset impairment charges | 0 | 213
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | 2,431 | 2,852
Other assets | 1,363 | (534)
Operating lease liabilities | (4,132) | 2,991
Accounts payable | 4,746 | (575)
Accrued compensation | 5,745 | (4)
Accrued manufacturing expenses | 33,614 | 5,830
Accrued expenses | (511) | 5,477
Net cash used in operating activities | (167,980) | (105,376)
Cash flows from investing activities: |  |
Purchases of property and equipment | (10,808) | (4,701)
Purchases of investments | (1,126,286) | (31,460)
Maturities of investments | 368,919 | 136,191
Sale of investments | 8,790 | 10,500
Proceeds from sale of property and equipment | 0 | 7
Net cash (used in) provided by investing activities | (759,385) | 110,537
Cash flows from financing activities: |  |
Proceeds from exercise of common stock options | 3,541 | 2,363
Proceeds from issuance of common stock related to at-the-market offering, net of issuance costs | 90,787 | 95,238
Proceeds from issuance of common stock from follow-on offering, net of issuance costs | 545,279 | 107,624
Release of restricted stock units | (3,546) | (861)
Proceeds from issuance of common stock under Employee Stock Purchase Plan | 1,017 | 550
Net cash provided by financing activities | 637,078 | 204,914
Effect of exchange rate changes on cash and cash equivalents | 996 | (659)
Net (decrease) increase in cash, cash equivalents and restricted cash | (289,291) | 209,416
Cash, cash equivalents and restricted cash, beginning of period | 835,528 | 69,856
Cash, cash equivalents and restricted cash, end of period | 546,237 | 279,272
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | 0 | 2
Supplemental disclosure of non-cash investing activities: |  |
Purchases of property and equipment recorded in accounts payable and accrued expenses | $ 433 | $ 141

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