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Condensed Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2023
Sep. 30, 2022
Cash flows from operating activities:    
Net loss $ (221,465) $ (145,435)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,268 1,875
Stock-based compensation expense 35,412 16,641
Amortization of operating lease right-of-use assets 4,955 5,021
Net amortization (accretion) of premiums (discounts) on investments (32,406) 228
Loss on disposal of fixed assets 0 44
Asset impairment charges 0 213
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets 2,431 2,852
Other assets 1,363 (534)
Operating lease liabilities (4,132) 2,991
Accounts payable 4,746 (575)
Accrued compensation 5,745 (4)
Accrued manufacturing expenses 33,614 5,830
Accrued expenses (511) 5,477
Net cash used in operating activities (167,980) (105,376)
Cash flows from investing activities:    
Purchases of property and equipment (10,808) (4,701)
Purchases of investments (1,126,286) (31,460)
Maturities of investments 368,919 136,191
Sale of investments 8,790 10,500
Proceeds from sale of property and equipment 0 7
Net cash (used in) provided by investing activities (759,385) 110,537
Cash flows from financing activities:    
Proceeds from exercise of common stock options 3,541 2,363
Proceeds from issuance of common stock related to at-the-market offering, net of issuance costs 90,787 95,238
Proceeds from issuance of common stock from follow-on offering, net of issuance costs 545,279 107,624
Release of restricted stock units (3,546) (861)
Proceeds from issuance of common stock under Employee Stock Purchase Plan 1,017 550
Net cash provided by financing activities 637,078 204,914
Effect of exchange rate changes on cash and cash equivalents 996 (659)
Net (decrease) increase in cash, cash equivalents and restricted cash (289,291) 209,416
Cash, cash equivalents and restricted cash, beginning of period 835,528 69,856
Cash, cash equivalents and restricted cash, end of period 546,237 279,272
Supplemental disclosure of cash flow information:    
Cash paid for interest 0 2
Supplemental disclosure of non-cash investing activities:    
Purchases of property and equipment recorded in accounts payable and accrued expenses $ 433 $ 141