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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (223,723) | $ (128,801)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 2,351 | 1,462
Stock-based compensation expense | 39,187 | 22,192
Amortization of operating lease right-of-use assets | 4,218 | 3,281
Net accretion of discounts on investments | (20,925) | (17,834)
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (1,964) | (4,693)
Other assets | (15,127) | 1,077
Operating lease liabilities | (3,643) | (2,732)
Accounts payable | (5,036) | 4,052
Accrued compensation | (4,593) | 3,235
Accrued manufacturing expenses | (16,294) | 6,103
Accrued expenses | (34,969) | 2,226
Net cash used in operating activities | (280,518) | (110,432)
Cash flows from investing activities: |  |
Purchases of property and equipment | (13,459) | (3,469)
Purchases of investments | (1,038,346) | (916,613)
Purchases related to manufacturing facility and equipment construction-in-progress | (37,593) | 0
Maturities of investments | 541,988 | 135,999
Sales of investments | 15,931 | 2,418
Net cash used in investing activities | (531,479) | (781,665)
Cash flows from financing activities: |  |
Proceeds from exercise of common stock options | 7,768 | 1,386
Proceeds from issuance of common stock related to at-the-market offerings, net of issuance costs | 106,509 | 41,787
Proceeds from issuance of common stock from follow-on offerings, net of issuance costs | 816,503 | 545,279
Release of restricted stock units | (3,871) | (941)
Proceeds from issuance of common stock under Employee Stock Purchase Plan | 1,655 | 1,017
Net cash provided by financing activities | 928,564 | 588,528
Effect of exchange rate changes on cash and cash equivalents | 4,652 | (55)
Net increase (decrease) in cash, cash equivalents and restricted cash | 121,219 | (303,624)
Cash, cash equivalents and restricted cash, beginning of period | 398,554 | 835,528
Cash, cash equivalents and restricted cash, end of period | 519,773 | 531,904
Supplemental disclosure of non-cash investing activities: |  |
Purchases of property and equipment recorded in accounts payable and accrued expenses | 5,279 | 4,162
Proceeds from issuance of common stock from at-the-market offering, not yet received | $ 9,414 | $ 0

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