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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2024
Jun. 30, 2023
Cash flows from operating activities:    
Net loss $ (223,723) $ (128,801)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 2,351 1,462
Stock-based compensation expense 39,187 22,192
Amortization of operating lease right-of-use assets 4,218 3,281
Net accretion of discounts on investments (20,925) (17,834)
Changes in operating assets and liabilities:    
Prepaid expenses and other current assets (1,964) (4,693)
Other assets (15,127) 1,077
Operating lease liabilities (3,643) (2,732)
Accounts payable (5,036) 4,052
Accrued compensation (4,593) 3,235
Accrued manufacturing expenses (16,294) 6,103
Accrued expenses (34,969) 2,226
Net cash used in operating activities (280,518) (110,432)
Cash flows from investing activities:    
Purchases of property and equipment (13,459) (3,469)
Purchases of investments (1,038,346) (916,613)
Purchases related to manufacturing facility and equipment construction-in-progress (37,593) 0
Maturities of investments 541,988 135,999
Sales of investments 15,931 2,418
Net cash used in investing activities (531,479) (781,665)
Cash flows from financing activities:    
Proceeds from exercise of common stock options 7,768 1,386
Proceeds from issuance of common stock related to at-the-market offerings, net of issuance costs 106,509 41,787
Proceeds from issuance of common stock from follow-on offerings, net of issuance costs 816,503 545,279
Release of restricted stock units (3,871) (941)
Proceeds from issuance of common stock under Employee Stock Purchase Plan 1,655 1,017
Net cash provided by financing activities 928,564 588,528
Effect of exchange rate changes on cash and cash equivalents 4,652 (55)
Net increase (decrease) in cash, cash equivalents and restricted cash 121,219 (303,624)
Cash, cash equivalents and restricted cash, beginning of period 398,554 835,528
Cash, cash equivalents and restricted cash, end of period 519,773 531,904
Supplemental disclosure of non-cash investing activities:    
Purchases of property and equipment recorded in accounts payable and accrued expenses 5,279 4,162
Proceeds from issuance of common stock from at-the-market offering, not yet received $ 9,414 $ 0