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Condensed Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Preferred Stock
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Retained Deficit
Preferred stock, beginning balance (in shares) at Dec. 31, 2021   0        
Beginning balance (in shares) at Dec. 31, 2021     1,796,529,000      
Beginning balance at Dec. 31, 2021 $ 365,431 $ 0 $ 180 $ 2,146,710 $ 1,890 $ (1,783,349)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation (in shares)     703,000      
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation 2,230     2,230    
Contribution of services 47     47    
Issuance and recognition of stock-based compensation of employee stock purchase plan 117     117    
Common stock issued in connection with conversion of 2013 8.00% Notes (in shares)     2,253,000      
Common stock issued in connection with conversion of 2013 8.00% Notes 2,548   $ 0 2,548    
Other comprehensive (loss) income (679)       (679)  
Net income (loss) (20,462)         (20,462)
Preferred stock, ending balance (in shares) at Mar. 31, 2022   0        
Ending balance (in shares) at Mar. 31, 2022     1,799,485,000      
Ending balance at Mar. 31, 2022 349,232 $ 0 $ 180 2,151,652 1,211 (1,803,811)
Preferred stock, beginning balance (in shares) at Dec. 31, 2021   0        
Beginning balance (in shares) at Dec. 31, 2021     1,796,529,000      
Beginning balance at Dec. 31, 2021 365,431 $ 0 $ 180 2,146,710 1,890 (1,783,349)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net income (loss) (251,580)          
Preferred stock, ending balance (in shares) at Sep. 30, 2022   0        
Ending balance (in shares) at Sep. 30, 2022     1,800,523,000      
Ending balance at Sep. 30, 2022 135,580 $ 0 $ 180 2,155,117 15,212 (2,034,929)
Preferred stock, beginning balance (in shares) at Mar. 31, 2022   0        
Beginning balance (in shares) at Mar. 31, 2022     1,799,485,000      
Beginning balance at Mar. 31, 2022 349,232 $ 0 $ 180 2,151,652 1,211 (1,803,811)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation (in shares)     546,000      
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation 879     879    
Contribution of services 47     47    
Net issuance of stock through employee stock purchase plan and recognition of stock-based compensation (in shares)     446,000      
Net issuance of stock through employee stock purchase plan and recognition of stock-based compensation 617     617    
Other comprehensive (loss) income 5,315       5,315  
Net income (loss) (26,757)         (26,757)
Preferred stock, ending balance (in shares) at Jun. 30, 2022   0        
Ending balance (in shares) at Jun. 30, 2022     1,800,477,000      
Ending balance at Jun. 30, 2022 329,333 $ 0 $ 180 2,153,195 6,526 (1,830,568)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation (in shares)     46,000      
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation 1,815     1,815    
Contribution of services 47     47    
Issuance and recognition of stock-based compensation of employee stock purchase plan 60     60    
Other comprehensive (loss) income 8,686       8,686  
Net income (loss) (204,361)         (204,361)
Preferred stock, ending balance (in shares) at Sep. 30, 2022   0        
Ending balance (in shares) at Sep. 30, 2022     1,800,523,000      
Ending balance at Sep. 30, 2022 $ 135,580 $ 0 $ 180 2,155,117 15,212 (2,034,929)
Preferred stock, beginning balance (in shares) at Dec. 31, 2022 0 149,000        
Beginning balance (in shares) at Dec. 31, 2022     1,811,075,000      
Beginning balance at Dec. 31, 2022 $ 314,771 $ 0 $ 181 2,345,612 9,242 (2,040,264)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation (in shares)     2,037,000      
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation 3,795     3,795    
Contribution of services 47     47    
Issuance and recognition of stock-based compensation of employee stock purchase plan 102     102    
Series A Preferred Stock Dividends (3,952)     (3,952)    
Other comprehensive (loss) income (1,429)       (1,429)  
Net income (loss) (3,480)         (3,480)
Preferred stock, ending balance (in shares) at Mar. 31, 2023   149,000        
Ending balance (in shares) at Mar. 31, 2023     1,813,112,000      
Ending balance at Mar. 31, 2023 $ 309,854 $ 0 $ 181 2,345,604 7,813 (2,043,744)
Preferred stock, beginning balance (in shares) at Dec. 31, 2022 0 149,000        
Beginning balance (in shares) at Dec. 31, 2022     1,811,075,000      
Beginning balance at Dec. 31, 2022 $ 314,771 $ 0 $ 181 2,345,612 9,242 (2,040,264)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net income (loss) $ (9,640)          
Preferred stock, ending balance (in shares) at Sep. 30, 2023 0 149,000        
Ending balance (in shares) at Sep. 30, 2023     1,876,120,000      
Ending balance at Sep. 30, 2023 $ 383,366 $ 0 $ 188 2,424,073 9,009 (2,049,904)
Preferred stock, beginning balance (in shares) at Mar. 31, 2023   149,000        
Beginning balance (in shares) at Mar. 31, 2023     1,813,112,000      
Beginning balance at Mar. 31, 2023 309,854 $ 0 $ 181 2,345,604 7,813 (2,043,744)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation (in shares)     363,000      
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation 1,874     1,874    
Contribution of services 47     47    
Net issuance of stock through employee stock purchase plan and recognition of stock-based compensation (in shares)     497,000      
Net issuance of stock through employee stock purchase plan and recognition of stock-based compensation 636     636    
Series A Preferred Stock Dividends (2,644)     (2,644)    
Fair value of Thermo guarantee associated with the 2023 Funding Agreement 6,897     6,897    
Other comprehensive (loss) income (1,307)       (1,307)  
Net income (loss) 9         9
Preferred stock, ending balance (in shares) at Jun. 30, 2023   149,000        
Ending balance (in shares) at Jun. 30, 2023     1,813,972,000      
Ending balance at Jun. 30, 2023 315,366 $ 0 $ 181 2,352,414 6,506 (2,043,735)
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation (in shares)     2,171,000      
Net issuance of restricted stock awards and stock for employee stock options and recognition of stock-based compensation 3,871   $ 1 3,870    
Contribution of services 47     47    
Series A Preferred Stock Dividends (2,673)     (2,673)    
Issuance of stock in connection with License Agreement with XCOM (in shares)     59,977,000      
Issuance of stock in connection with License Agreement with XCOM 70,421   $ 6 70,415    
Other comprehensive (loss) income 2,503       2,503  
Net income (loss) $ (6,169)         (6,169)
Preferred stock, ending balance (in shares) at Sep. 30, 2023 0 149,000        
Ending balance (in shares) at Sep. 30, 2023     1,876,120,000      
Ending balance at Sep. 30, 2023 $ 383,366 $ 0 $ 188 $ 2,424,073 $ 9,009 $ (2,049,904)