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Consolidated Statements of Stockholders' Equity - USD ($)
$ in Thousands
Total
Preferred Stock
Common Stock
Additional Paid-In Capital
Accumulated Other Comprehensive Income (Loss)
Retained Deficit
Preferred stock, balance, beginning (in shares) at Dec. 31, 2020   0        
Beginning balance at Dec. 31, 2020 $ 423,065 $ 0 $ 167 $ 2,096,566 $ (2,944) $ (1,670,724)
Beginning balance (in shares) at Dec. 31, 2020     1,674,669,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and employee stock options and recognition of stock-based compensation (in shares)     4,937,000      
Net issuance of restricted stock awards and employee stock options and recognition of stock-based compensation 5,544   $ 1 5,543    
Contribution of services 188     188    
Issuance and recognition of stock-based compensation of employee stock purchase plan (in shares)     1,887,000      
Issuance and recognition of stock-based compensation of employee stock purchase plan 747     747    
Issuance of stock for warrant exercises (in shares)     115,036,000      
Issuance of stock for warrant exercises 43,678   $ 12 43,666    
Other comprehensive income (loss) 4,834       4,834  
Net loss (112,625)         (112,625)
Preferred stock, balance, ending (in shares) at Dec. 31, 2021   0        
Ending balance at Dec. 31, 2021 365,431 $ 0 $ 180 2,146,710 1,890 (1,783,349)
Ending balance (in shares) at Dec. 31, 2021     1,796,529,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and employee stock options and recognition of stock-based compensation (in shares)     11,577,000      
Net issuance of restricted stock awards and employee stock options and recognition of stock-based compensation 10,589   $ 1 10,588    
Contribution of services 188     188    
Issuance and recognition of stock-based compensation of employee stock purchase plan (in shares)     716,000      
Issuance and recognition of stock-based compensation of employee stock purchase plan 1,135     1,135    
Common stock issued in connection with conversion of 2013 8.00% Notes (in shares)     2,253,000      
Common stock issued in connection with conversion of 2013 8.00% Notes 2,548     2,548    
Issuance of warrants 48,337     48,337    
Issuance of Series A Preferred Stock & Dividends (in shares)   149,000        
Issuance of Series A Preferred Stock & Dividends 105,342     105,342    
Gain on extinguishment of 2019 Facility Agreement with Thermo 30,764     30,764    
Other comprehensive income (loss) 7,352       7,352  
Net loss $ (256,915)         (256,915)
Preferred stock, balance, ending (in shares) at Dec. 31, 2022 0 149,000        
Ending balance at Dec. 31, 2022 $ 314,771 $ 0 $ 181 2,345,612 9,242 (2,040,264)
Ending balance (in shares) at Dec. 31, 2022     1,811,075,000      
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net issuance of restricted stock awards and employee stock options and recognition of stock-based compensation (in shares)     9,256,000      
Net issuance of restricted stock awards and employee stock options and recognition of stock-based compensation 19,287   $ 1 19,286    
Contribution of services $ 188     188    
Issuance and recognition of stock-based compensation of employee stock purchase plan (in shares) 13,600,000   887,000      
Issuance and recognition of stock-based compensation of employee stock purchase plan $ 1,270     1,270    
Series A Preferred Dividends (11,942)     (11,942)    
Fair value of Thermo guarantees associated with 2023 Funding Agreement 8,864     8,864    
Issuance of warrants 5,010     5,010    
Issuance of stock in connection with License Agreement with XCOM (in shares)     59,977,000      
Issuance of stock in connection with License Agreement with XCOM 70,421   $ 6 70,415    
Other comprehensive income (loss) (4,172)       (4,172)  
Net loss $ (24,718)         (24,718)
Preferred stock, balance, ending (in shares) at Dec. 31, 2023 0 149,000        
Ending balance at Dec. 31, 2023 $ 378,979 $ 0 $ 188 $ 2,438,703 $ 5,070 $ (2,064,982)
Ending balance (in shares) at Dec. 31, 2023     1,881,195,000