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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Mar. 31, 2022 | Mar. 31, 2021 | Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities |  |  |  |
Net loss | $ (32,385) | $ (11,281) | $ (64,969) | $ (32,095)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |
Depreciation and amortization | 416 | 207 | 1,041 | 629
Noncash operating lease expense | 60 |  |  |
Amortization of premiums and discounts on marketable securities | 110 |  | 210 |
Share-based compensation | 4,481 | 757 | 6,754 | 1,051
Loss on disposal of property and equipment |  |  | 3 |
Changes in operating assets and liabilities: |  |  |  |
Prepaid expenses and other current and non-current assets | (8,423) | 48 | (6,059) | 331
Accounts payable and other current liabilities | 696 | 321 | 974 | (1,333)
Accrued liabilities | 2,563 | 392 | 7,764 | 2,776
Operating lease liabilities | (104) |  |  |
Deferred rent |  | 49 | 44 | (21)
Net cash used in operating activities | (32,586) | (9,507) | (54,238) | (28,662)
Cash flows from investing activities |  |  |  |
Purchases of property and equipment | (467) | (1,066) | (5,783) | (888)
Purchases of marketable securities | (27,026) |  | (74,193) |
Proceeds from maturities of marketable securities | 16,850 |  |  |
Net cash used in investing activities | (10,643) | (1,066) | (79,976) | (888)
Cash flows from financing activities |  |  |  |
Payments under capital leases |  |  | (387) |
Proceeds from the exercise of stock options | 429 | 7 | 432 | 40
Payments of deferred offering costs |  | (14) | (688) | (1,185)
Payment for repurchase of restricted stock |  |  | (24) |
Proceeds from issuance of Series C redeemable convertible preferred stock, net of transaction costs |  | 81,756 |  |
Proceeds from issuance of common stock (initial public offering), net of transactions costs | 129,156 |  |  |
Proceeds from issuance of common stock (private placement), net of transactions costs | 10,000 |  |  |
Payments under finance leases | (29) | (121) |  |
Net cash provided by financing activities | 139,556 | 81,628 | 118,451 | 41,656
Net increase in cash and cash equivalents and restricted cash | 96,327 | 71,055 | (15,763) | 12,106
Cash and cash equivalents and restricted cash, beginning of the year | 31,032 | 46,795 | 46,795 | 34,689
Cash and cash equivalents and restricted cash, end of the period | 127,359 | 117,850 | 31,032 | 46,795
Supplemental disclosures of noncash investing and financing activities: |  |  |  |
Purchase of property and equipment included in accounts payable and accrued liabilities | 35 | $ 238 | 278 | 311
Deferred offering costs included in accrued liabilities | $ 42 |  | 1,301 | 576
Series B Redeemable Convertible Preferred Stock |  |  |  |
Cash flows from financing activities |  |  |  |
Proceeds from issuance of Series C redeemable convertible preferred stock, net of transaction costs |  |  |  | $ 42,801
Series C Redeemable Convertible Preferred Stock |  |  |  |
Cash flows from financing activities |  |  |  |
Proceeds from issuance of Series C redeemable convertible preferred stock, net of transaction costs |  |  | $ 119,118 |

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