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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2023 | Mar. 31, 2022
Cash flows from operating activities |  |
Net loss | $ (27,344) | $ (26,041)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 432 | 263
Noncash operating lease expense | 310 | 60
Right of use asset expensed | 1,705 |
Amortization of premiums and discounts on marketable securities | (1,978) | 110
Share-based compensation | 10,156 | 4,481
Changes in operating assets and liabilities: |  |
Receivable from collaboration partner | (21,230) |
Prepaid expenses and other current and non-current assets | (4,931) | (11,864)
Accounts payable and other current liabilities | (4,237) | 696
Accrued liabilities | (173) | (187)
Operating lease liabilities | 1,013 | (104)
Contract liability | 228,319 |
Net cash provided by (used in) operating activities | 182,042 | (32,586)
Cash flows from investing activities |  |
Purchases of property and equipment | (980) | (467)
Purchases of marketable securities | (162,144) | (27,026)
Proceeds from maturities of marketable securities | 96,350 | 16,850
Net cash used in investing activities | (66,774) | (10,643)
Cash flows from financing activities |  |
Proceeds from issuance of common stock in accordance with Gilead Stock Purchase Agreement | 100,000 |
Proceeds from issuance of common stock (initial public offering), net of transactions costs |  | 129,156
Proceeds from issuance of common stock (private placement), net of transactions costs |  | 10,000
Proceeds from exercise of stock options | 374 | 429
Payments under finance leases | (4,929) | (29)
Net cash provided by financing activities | 95,445 | 139,556
Net increase in cash and cash equivalents and restricted cash | 210,713 | 96,327
Cash and cash equivalents and restricted cash, beginning of the year | 66,680 | 31,032
Cash and cash equivalents and restricted cash, end of the period | 277,393 | 127,359
Supplemental disclosures of noncash investing and financing activities: |  |
Purchase of property and equipment included in accounts payable and accrued liabilities | $ 2,709 | 35
Deferred offering costs included in accounts payable and accrued liabilities |  | $ 42

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