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Leases - Additional Information (Details)
$ in Thousands
 1 Months Ended 3 Months Ended
Jul. 31, 2022
USD ($)
ft²
May 31, 2022
USD ($)
ft²
Mar. 31, 2023
USD ($)
Mar. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
Lessee, Lease, Description [Line Items]          
Undiscounted minimum lease payments     $ 95,265    
Research and development expense on finance lease liabilities     32,932 $ 18,057  
Finance lease liabilities, current     35,294   $ 33,060
Finance lease liabilities, non-current     15,413   $ 20,871
Lonza          
Lessee, Lease, Description [Line Items]          
Research and development expense on finance lease liabilities     1,700    
Finance lease liabilities, current     35,200    
Finance lease liabilities, non-current     $ 15,400    
Prior notification period to terminate arrangement     12 months    
Finance lease expiration date     2024-12    
Lonza | Other Income, Net          
Lessee, Lease, Description [Line Items]          
Interest expense on finance lease liabilities     $ 1,000    
Redwood, California          
Lessee, Lease, Description [Line Items]          
Square feet of space | ft²   51,822      
Lease term   11 years 8 months 12 days      
Undiscounted minimum lease payments     $ 55,400    
Option to extend lease     The Redwood City lease provides for an optional five-year extension.    
Option to extend lease term   5 years      
Lease includes allowance for tenant improvements   $ 9,800      
Operating lease, discount rate   8.50%      
Rockville, Maryland          
Lessee, Lease, Description [Line Items]          
Square feet of space | ft² 57,902        
Lease term 12 years 10 months 24 days        
Undiscounted minimum lease payments     $ 33,700    
Option to extend lease     The Rockville lease provides for optional two five-year extensions.    
Option to extend lease term 5 years        
Lease includes allowance for tenant improvements $ 12,100   $ 2,800    
Operating lease, discount rate 10.20%        
Increase in operating lease right-of-use asset and lease liability     $ 1,300    
Office and Laboratory Space | Rockville, Maryland          
Lessee, Lease, Description [Line Items]          
Lease expiration year     2030