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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2024 | Sep. 30, 2023
Cash flows from operating activities |  |
Net loss | $ (60,267) | $ (90,534)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |
Depreciation and amortization | 3,399 | 1,318
Non-cash operating lease expense | 3,165 | 813
Right-of-use asset expensed | 888 | 18,247
Amortization of premiums and discounts on marketable securities | (11,891) | (7,104)
Share-based compensation | 45,317 | 31,174
Changes in operating assets and liabilities: |  |
Receivable from collaboration partner |  | (31,480)
Prepaid expenses and other current and non-current assets | 7,629 | (14,991)
Accounts payable and other current liabilities | 3,514 | (1,648)
Accrued liabilities | 27,633 | (1,420)
Operating lease liabilities | (3,150) | 13,883
Contract liability to related party | (68,722) | 231,067
Other non-current liabilities | 15,048 |
Net cash provided by (used in) operating activities | (37,437) | 149,325
Cash flows from investing activities |  |
Purchases of property and equipment | (11,935) | (16,135)
Purchases of marketable securities | (460,990) | (400,044)
Proceeds from maturities of marketable securities | 294,000 | 240,650
Net cash used in investing activities | (178,925) | (175,529)
Cash flows from financing activities |  |
Proceeds from issuance of common stock in accordance with Gilead Stock Purchase Agreement |  | 100,000
Proceeds from exercise of stock options | 10,590 | 4,582
Proceeds from stock issued pursuant to employee stock purchase plan | 646 |
Principal payments under finance leases | (29,306) | (14,010)
Net cash provided by (used in) financing activities | (18,070) | 90,572
Net increase (decrease) in cash and cash equivalents and restricted cash | (234,432) | 64,368
Cash and cash equivalents and restricted cash, beginning of the period | 398,904 | 66,680
Cash and cash equivalents and restricted cash, end of the period | 164,472 | 131,048
Supplemental disclosure of cash flow information: |  |
Cash paid for income taxes | 1,467 | 212
Supplemental disclosures of noncash investing and financing activities: |  |
Purchase of property and equipment included in accounts payable and accrued liabilities | $ 1,334 | $ 7,206

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