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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2024
Sep. 30, 2023
Cash flows from operating activities    
Net loss $ (60,267) $ (90,534)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:    
Depreciation and amortization 3,399 1,318
Non-cash operating lease expense 3,165 813
Right-of-use asset expensed 888 18,247
Amortization of premiums and discounts on marketable securities (11,891) (7,104)
Share-based compensation 45,317 31,174
Changes in operating assets and liabilities:    
Receivable from collaboration partner   (31,480)
Prepaid expenses and other current and non-current assets 7,629 (14,991)
Accounts payable and other current liabilities 3,514 (1,648)
Accrued liabilities 27,633 (1,420)
Operating lease liabilities (3,150) 13,883
Contract liability to related party (68,722) 231,067
Other non-current liabilities 15,048  
Net cash provided by (used in) operating activities (37,437) 149,325
Cash flows from investing activities    
Purchases of property and equipment (11,935) (16,135)
Purchases of marketable securities (460,990) (400,044)
Proceeds from maturities of marketable securities 294,000 240,650
Net cash used in investing activities (178,925) (175,529)
Cash flows from financing activities    
Proceeds from issuance of common stock in accordance with Gilead Stock Purchase Agreement   100,000
Proceeds from exercise of stock options 10,590 4,582
Proceeds from stock issued pursuant to employee stock purchase plan 646  
Principal payments under finance leases (29,306) (14,010)
Net cash provided by (used in) financing activities (18,070) 90,572
Net increase (decrease) in cash and cash equivalents and restricted cash (234,432) 64,368
Cash and cash equivalents and restricted cash, beginning of the period 398,904 66,680
Cash and cash equivalents and restricted cash, end of the period 164,472 131,048
Supplemental disclosure of cash flow information:    
Cash paid for income taxes 1,467 212
Supplemental disclosures of noncash investing and financing activities:    
Purchase of property and equipment included in accounts payable and accrued liabilities $ 1,334 $ 7,206